A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric analogues [PDF]
Beilstein Journal of Organic Chemistry, 2012 The cyclic peptide core of the antifungal and antibiotic cyclic depsipeptide LI-F04a was synthesised by using a modified Yamaguchi macrolactonization approach.
James R. Cochrane +3 more
doaj +5 more sources
Structure and Antibacterial Activity of Ambobactin, a New Telomycin-Like Cyclic Depsipeptide Antibiotic Produced by Streptomyces ambofaciens F3 [PDF]
Molecules, 2015 A new telomycin-like cyclic depsipeptide, ambobactin (1), was isolated from the metabolites of Streptomyces ambofaciens F3, an endophyte of Platycladus orientalis.
Shaopeng Wei, Wenhao Zhang, Zhiqin Ji
doaj +6 more sources
Stereocalpin B, a New Cyclic Depsipeptide from the Antarctic Lichen Ramalina terebrata [PDF]
Metabolites, 2022 Stereocalpin B, a new cyclic depsipeptide (1), and a new dibenzofuran derivative (3), were isolated from the Antarctic lichen, Ramalina terebrata (Ramalinaceae), along with a known cyclic depsipeptide (2).
Seulah Lee +9 more
doaj +4 more sources
Benderamide A, a Cyclic Depsipeptide from a Singapore Collection of Marine Cyanobacterium cf. Lyngbya sp. [PDF]
Marine Drugs, 2018 Benderamide A (1), a (S)-2,2-dimethyl-3-hydroxy-7-octynoic acid (S-Dhoya)-containing cyclic depsipeptide that belongs to the kulolide superfamily, was isolated from a Singapore collection of cf. Lyngbya sp.
Chi Ying Gary Ding +4 more
doaj +4 more sources
Total Synthesis of the Marine Cyclic Depsipeptide Lagunamide D [PDF]
Marine DrugsLagunamide D is a structurally distinct 26-membered cytotoxic cyclic depsipeptide, originally isolated from a marine cyanobacterium. It exhibits potent antiproliferative activity in the low nanomolar range against A549 human lung adenocarcinoma cells and
Huiru Nan +8 more
doaj +4 more sources
Production of a New Cyclic Depsipeptide by the Culture Broth of Staphylococcus sp. Isolated from Corallina officinalis L. [PDF]
Metabolites, 2019 A new cyclic depsipeptide (1) has been isolated from culture broth of Staphylococcus sp. (No. P-100826-4-6) derived from Corallina officinalis L., together with the known compounds indol-3-carboxylic acid (2), 1,5-dideoxy-3-C-methyl arabinitol (3 ...
Reda F. A. Abdelhameed +7 more
doaj +5 more sources
Isolation and Total Synthesis of PM170453, a New Cyclic Depsipeptide Isolated from Lyngbya sp. [PDF]
Marine DrugsIn our continuing search for biologically active new chemical entities from marine organisms, we have isolated a new cyclic depsipeptide, PM170453 (1), from a cyanobacterium of the genus Lyngbya sp., collected in the Indo-Pacific Ocean.
Rogelio Fernández +8 more
doaj +4 more sources
Acetylation of FoxO1 Activates Bim Expression to Induce Apoptosis in Response to Histone Deacetylase Inhibitor Depsipeptide Treatment [PDF]
Neoplasia: An International Journal for Oncology Research, 2009 Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and apoptosis in cancer cells. However, the mechanisms of HDAC inhibitor induced apoptosis are incompletely understood. In this study, depsipeptide, a novel HDAC inhibitor,
Yang Yang +11 more
doaj +2 more sources
Consecutive isocyanide-based multicomponent reactions: synthesis of cyclic pentadepsipeptoids [PDF]
Beilstein Journal of Organic Chemistry, 2014 The synthesis of six cyclic depsipeptoids inspired by the natural depsipeptide sansalvamide A is described. An efficient and fast synthetic strategy was developed using a combination of consecutive isocyanide-based multicomponent reactions (Ugi and ...
Angélica de Fátima S. Barreto +3 more
doaj +5 more sources
Total Synthesis of the Cyclic Depsipeptide YM-280193, a Platelet Aggregation Inhibitor [PDF]
Organic Letters, 2015 The first total synthesis of YM-280193, a cyclic depsipeptide that inhibits the ADP-induced aggregation of human platelets, is described. The monomer and dipeptide fragments were prepared using conventional chemistry and subsequently assembled by Fmoc-solid-phase peptide synthesis (Fmoc-SPPS).
Kaur, Harveen +3 more
openaire +6 more sources