Results 11 to 20 of about 3,176 (160)

Cyclodepsipeptide Biosynthesis in Hypocreales Fungi and Sequence Divergence of The Non-Ribosomal Peptide Synthase Genes

Pathogens, 2020
Fungi from the Hypocreales order synthesize a range of toxic non-ribosomal cyclic peptides with antimicrobial, insecticidal and cytotoxic activities. Entomopathogenic Beauveria, Isaria and Cordyceps as well as phytopathogenic Fusarium spp.
Monika Urbaniak, Agnieszka Waśkiewicz, Artur Trzebny, Grzegorz Koczyk, Łukasz Stępień   +4 more
doaj   +1 more source

Acetylation of FoxO1 Activates Bim Expression to Induce Apoptosis in Response to Histone Deacetylase Inhibitor Depsipeptide Treatment

Neoplasia: An International Journal for Oncology Research, 2009
Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and apoptosis in cancer cells. However, the mechanisms of HDAC inhibitor induced apoptosis are incompletely understood. In this study, depsipeptide, a novel HDAC inhibitor,
Yang Yang, Ying Zhao, Wenjuan Liao, Jing Yang, Lipeng Wu, Zhixing Zheng, Yu Yu, Wen Zhou, Lian Li, Jingnan Feng, Haiying Wang, Wei-Guo Zhu   +11 more
doaj   +1 more source

Chemical Classification of Cyclic Depsipeptides

Current Protein & Peptide Science, 2017
Cyclic depsipeptides (CDPs) are a family of cyclic peptide-related compounds, of which the ring is mainly composed of amino- and hydroxy acid residues joined by amide and ester bonds (at least one), leading to a wide diversity of fascinating chemical structures. They differ in both their ring structure and their side chains, especially by the nature of
Taevernier, Lien, Wynendaele, Evelien, Gevaert, Bert, De Spiegeleer, Bart   +3 more
openaire   +3 more sources

Consecutive isocyanide-based multicomponent reactions: synthesis of cyclic pentadepsipeptoids

Beilstein Journal of Organic Chemistry, 2014
The synthesis of six cyclic depsipeptoids inspired by the natural depsipeptide sansalvamide A is described. An efficient and fast synthetic strategy was developed using a combination of consecutive isocyanide-based multicomponent reactions (Ugi and ...
Angélica de Fátima S. Barreto, Otilie E. Vercillo, Ludger A. Wessjohann, Carlos Kleber Z. Andrade   +3 more
doaj   +1 more source

Identification of 2,4-diacetylphloroglucinol production in the genus Chromobacterium

Scientific Reports, 2023
The compound 2,4-diacetylphloroglucinol (DAPG) is a broad-spectrum antibiotic that is primarily produced by Pseudomonas spp. DAPG plays an important role in the biocontrol disease suppressing activity of Pseudomonas spp.
Eric T. Johnson, Michael J. Bowman, Raylane Pereira Gomes, Lilian Carla Carneiro, Christopher A. Dunlap   +4 more
doaj   +1 more source

Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A

Angewandte Chemie, EarlyView.
Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham, Edward S. Hems, Daniel C. L. Van, Justin E. Clarke, Sergey Nepogodiev, Julius S. P. Adamson, Christian Bassi, Michael E. Webb, Glyn R. Hemsworth, Orde Q. Munro, Barrie Wilkinson, Ryan F. Seipke   +11 more
wiley   +2 more sources

Insights into the Antimicrobial Activities and Metabolomes of Aquimarina (Flavobacteriaceae, Bacteroidetes) Species from the Rare Marine Biosphere

Marine Drugs, 2022
Two novel natural products, the polyketide cuniculene and the peptide antibiotic aquimarin, were recently discovered from the marine bacterial genus Aquimarina.
Sandra Godinho Silva, Patrícia Paula, José Paulo da Silva, Dalila Mil-Homens, Miguel Cacho Teixeira, Arsénio Mendes Fialho, Rodrigo Costa, Tina Keller-Costa   +7 more
doaj   +1 more source

Characterisation of the Antibiotic Profile of Lysobacter capsici AZ78, an Effective Biological Control Agent of Plant Pathogenic Microorganisms

Microorganisms, 2021
Determining the mode of action of microbial biocontrol agents plays a key role in their development and registration as commercial biopesticides. The biocontrol rhizobacterium Lysobacter capsici AZ78 (AZ78) is able to inhibit a vast array of plant ...
Francesca Brescia, Anthi Vlassi, Ana Bejarano, Bernard Seidl, Martina Marchetti-Deschmann, Rainer Schuhmacher, Gerardo Puopolo   +6 more
doaj   +1 more source

Szentiamide, an -formylated Cyclic Depsipeptide from DSM 16338

Natural Product Communications, 2011
Szentiamide ( 1 ) a new cyclic hexadepsipeptide was isolated from the culture broth of the entomopathogenic bacterium Xenorhabdus szentirmaii DSM 16338 T .
Birgit Ohlendorf, Sven Simon, Jutta Wiese, Johannes F. Imhoff   +3 more
doaj   +1 more source

Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant Staphylococcus Aureus (MRSA)

Pharmaceutics, 2018
Teixobactin is a highly potent cyclic depsipeptide which kills a broad range of multi-drug resistant, Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) without detectable resistance.
Ruba Malkawi, Abhishek Iyer, Anish Parmar, Daniel G. Lloyd, Eunice Tze Leng Goh, Edward J. Taylor, Sarir Sarmad, Annemieke Madder, Rajamani Lakshminarayanan, Ishwar Singh   +9 more
doaj   +1 more source