Results 41 to 50 of about 3,681 (193)

Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum

Beilstein Journal of Organic Chemistry, 2012
The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from
Friederike I. Nollmann, Andrea Dowling, Marcel Kaiser, Klaus Deckmann, Sabine Grösch, Richard ffrench-Constant, Helge B. Bode   +6 more
doaj   +1 more source

Discovery of a gene cluster for the biosynthesis of novel cyclic peptide compound, KK-1, in Curvularia clavata

Frontiers in Fungal Biology, 2023
KK-1, a cyclic depsipeptide with 10 residues produced by a filamentous fungus Curvularia clavata BAUA-2787, is a promising pesticide active compound with high activity against many plant pathogens, especially Botrytis cinerea.
Shigenari Yamaguchi, Tomonori Fujioka, Akira Yoshimi, Akira Yoshimi, Toshitaka Kumagai, Maiko Umemura, Keietsu Abe, Keietsu Abe, Masayuki Machida, Masayuki Machida, Kiyoshi Kawai   +10 more
doaj   +1 more source

Total Synthesis of the Antifungal Depsipeptide Petriellin A [PDF]

, 2016
We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product.
Denis Scanlon (2175570), Andrew B. Hughes (2175572), John Karas (2175568), Marianne M. Sleebs (2175564), Rani Maharani (2175566)   +4 more
core   +1 more source

Sensitive LC-MS/MS Method for the Quantification of Macrocyclic Gαq Protein Inhibitors in Biological Samples

Frontiers in Chemistry, 2020
The cyclic depsipeptide FR900359 (FR) isolated from the plant Ardisia crenata and produced by endosymbiotic bacteria acts as a selective Gq protein inhibitor.
Markus Kuschak, Jonathan G. Schlegel, Marion Schneider, Stefan Kehraus, Jan H. Voss, Alexander Seidinger, Alexander Seidinger, Michaela Matthey, Michaela Matthey, Daniela Wenzel, Daniela Wenzel, Bernd K. Fleischmann, Gabriele M. König, Christa E. Müller   +13 more
doaj   +1 more source

Water-Based Dynamic Depsipeptide Chemistry: Building Block Recycling and Oligomer Distribution Control Using Hydration–Dehydration Cycles [PDF]

, 2022
The high kinetic barrier to amide bond formation has historically placed narrow constraints on its utility in reversible chemistry applications. Slow kinetics has limited the use of amides for the generation of diverse combinatorial libraries and ...
Martin C (12555208), Alyssa B. Sargon (12555217), Moran Frenkel-Pinter (237772), Kelvin H. Smith (12555211), Victor F. Rivera-Santana (12555214), Kaitlin C. Jacobson (12555220), Charles L. Liotta (1300020), Loren Dean Williams (15256), Aikomari Guzman-Martinez (2276893), Nicholas V. Hud (6641), Luke J. Leman (1913590), Martha A. Grover (173238)   +11 more
core   +1 more source

Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A

Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.
Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham, Edward S. Hems, Daniel C. L. Van, Justin E. Clarke, Sergey Nepogodiev, Julius S. P. Adamson, Christian Bassi, Michael E. Webb, Glyn R. Hemsworth, Orde Q. Munro, Barrie Wilkinson, Ryan F. Seipke   +11 more
wiley   +2 more sources

Synthesis of the cyclic heptapeptide core of callipeltin A [PDF]

, 2022
Macrolactonisation of a novel heptapeptide precursor with PyAOP proved to be an excellent method for preparation of the cyclic depsipeptide core of callipeltin A.
Horn, Alexander, Kazmaier, Uli
core   +1 more source

The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study

mSystems, 2020
Antibiotics have served humankind through their use in modern medicine as effective treatments for otherwise fatal bacterial infections. Teixobactin is a first member of newly discovered natural antibiotics that was recently identified from a hitherto ...
Maytham Hussein, John A. Karas, Elena K. Schneider-Futschik, Fan Chen, James Swarbrick, Olivia K. A. Paulin, Daniel Hoyer, Mark Baker, Yan Zhu, Jian Li, Tony Velkov   +10 more
doaj   +3 more sources

Total Synthesis of Cyclodepsipeptide Xylaroamide A

Chemistry
Cyclodepsipeptides constitute a structurally diverse class of natural products composed of amino acid and hydroxy acid residues interconnected through both amide and ester bonds.
Rongping Wu, Dongping Qiu, Yogini S. Jaiswal, Xinrong Xie, Leonard L. Williams, Yu Fan, Hedong Bian, Yifu Guan, Shaoyang Su   +8 more
doaj   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source