Results 61 to 70 of about 3,681 (193)

Visible‐Light Sensitized Isomerization in the Lipid Bilayer Enables Activation of a Transmembrane Transporter

Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.
A stiff‐stilbene‐based transmembrane anion transporter is isomerized by energy transfer from a ruthenium tris(bipyridyl) photosensitizer in the lipid bilayer. This sensitized isomerization allows activation of chloride transport using visible instead of UV light, without the need to chemically modify the stiff‐stilbene photoswitch.
Julia Villalva, Abhishek Mondal, Willem Marulanda, Jasper E. Bos, Sylvestre Bonnet, Anjali Pandit, Sander J. Wezenberg   +6 more
wiley   +2 more sources

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

Cyclic peptides and depsipeptides from cyanobacteria: A review

Journal of Industrial Microbiology, 1996
An elaborate array of structurally-novel and biologically-active cyclic peptides and depsipeptides are found in blue-green algae (cyanobacteria). Several of these compounds possess structures that are similar to those of natural products from marine invertebrates.
openaire   +2 more sources

Palmyramide A, a Cyclic Depsipeptide from a Palmyra Atoll Collection of the Marine Cyanobacterium Lyngbya majuscula [PDF]

, 2016
Bioassay-guided fractionation of the extract of a consortium of a marine cyanobacterium and a red alga (Rhodophyta) led to the discovery of a novel compound, palmyramide A, along with the known compounds curacin D and malyngamide C.
William H. Gerwick (176359), Masatoshi Taniguchi (2309488), Joshawna K. Nunnery (2309485), Niclas Engene (1393330), Pieter C. Dorrestein (224907), Eduardo Esquenazi (224901), Tara Byrum (1316922)   +6 more
core   +1 more source

Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons

Marine Drugs, 2015
The frequent occurrence of Moorea producens (formerly Lyngbya majuscula) blooms has been associated with adverse effects on human health. Hoiamide A is a structurally unique cyclic depsipeptide isolated from an assemblage of the marine cyanobacteria M ...
Zhengyu Cao, Xichun Li, Xiaohan Zou, Michael Greenwood, William H. Gerwick, Thomas F. Murray   +5 more
doaj   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, Volume 13, Issue 38, 9 July 2026.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Total synthesis of the antifungal depsipeptide petriellin A [PDF]

, 2011
Publication Date (Web): July 8, 2011We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase
Sleebs, MM, Karas, J, Maharani, R, Sleebs, M., John Karas, Scanlon, D, Hughes, AB, Marianne M. Sleebs, Scanlon, D., Maharani, R., Denis Scanlon, Hughes, A., Karas, J., Rani Maharani, Andrew B. Hughes   +14 more
core   +1 more source

From Prebiotic Catalysts to Modern Applications: How Early Catalysts Inspire Today's Innovations

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
Simple catalytic systems that may have operated under prebiotic conditions offer useful molecular principles for the design of modern functional materials. By examining how amino acids, peptide assemblies, and metal complexes achieve catalysis through simple chemical features, this review highlights how prebiotic chemistry can inspire new strategies ...
Omer Agazani, Meital Reches
wiley   +1 more source

A Chemical Study of Cyclic Depsipeptides Produced by a Sponge-Derived Fungus [PDF]

Journal of Natural Products, 2006
Two novel cyclic depsipeptides, guangomides A (1) and B (2), together with a new destruxin derivative (3) were isolated from the cytotoxic extract obtained from the saltwater culture of an unidentifiable sponge-derived fungus. The new structures were elucidated on the basis of analysis of extensive 1D and 2D NMR data sets, and the absolute ...
Taro, Amagata, Brandon I, Morinaka, Akiko, Amagata, Karen, Tenney, Frederick A, Valeriote, Emil, Lobkovsky, Jon, Clardy, Phillip, Crews   +7 more
openaire   +2 more sources

Concise and Stereospecific Total Synthesis of Arenastatin A and Its Segment B Analogs

Molecules
A novel and concise synthetic method for arenastatin A, a cytotoxic cyclic depsipeptide of marine origin, was developed in this study. The convergent assembly of the four segments, including the cross-metathesis reaction, gave a cyclization precursor ...
Yurina Mihara, Haruki Kadoya, Soki Kakihana, Naoyuki Kotoku   +3 more
doaj   +1 more source