Results 61 to 70 of about 433,171 (190)
Concise and Stereospecific Total Synthesis of Arenastatin A and Its Segment B Analogs
MoleculesA novel and concise synthetic method for arenastatin A, a cytotoxic cyclic depsipeptide of marine origin, was developed in this study. The convergent assembly of the four segments, including the cross-metathesis reaction, gave a cyclization precursor ...
Yurina Mihara +3 more
doaj +1 more source
International Journal for Parasitology: Drugs and Drug Resistance, 2017 Histone deacetylase inhibitors (HDACi) are being investigated for the control of various human parasites. Here we investigate their potential as insecticides for the control of a major ecto-parasite of sheep, the Australian sheep blowfly, Lucilia cuprina.
Neil H. Bagnall +6 more
doaj +1 more source
SEPARATION SCIENCE PLUS, Volume 9, Issue 9, September 2026.Response surface optimization identified 60% microwave power and 40 s as a balanced condition for recovering bioactive compounds from Arisaema schimperianum tuber. LC–MS/MS profiling revealed diverse metabolites, while freeze‐drying best preserved thermolabile compounds, highlighting an effective strategy for maximizing extraction efficiency and ...
Gezahegn Abawa Zeleke +2 more
wiley +1 more source
, 2016 A cyclic peptide was isolated from the deep-sea marine sponge Discodermia japonica, and its NMR spectroscopic data were identical to those reported for cyclolithistide A, a known antifungal depsipeptide.
Kentaro Takada (1476262) +4 more
core +1 more source
Tryptophan‐Selective Chemical Modification of Peptides by Thioether‐Mediated Sulfenylation
ChemistryEuropeChemical modification of biomolecules such as peptides and proteins is an important technology for the development of new functional molecules. Herein, a thioether‐mediated sulfenylation for tryptophan (Trp)‐selective chemical modification under mild ...
Hayate Shida +11 more
doaj +1 more source
The role of cyclic nucleotide on fetal and neonantal erythropoiesis [PDF]
, 1974 For the purpose to reveal the changes in stimulatory effect of dibutyryl-cyclic- AMP on erythropoiesis during ontogenetic development, the author studied syntheses of DNA, RNA and protein of erythroid cells in fetal liver, neonatal and adult bone marrows
Tada, Hiroshi
core +1 more source
Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
Chemistry – A European Journal, Volume 32, Issue 30, 13 August 2026.ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source
Ulongapeptin, a Cytotoxic Cyclic Depsipeptide from a Palauan Marine Cyanobacterium Lyngbya sp.
, 2016 Ulongapeptin (1), a cyclic depsipeptide, was isolated from a Palauan marine cyanobacterium Lyngbya sp. The gross structure was elucidated through one-dimensional TOCSY experiments and other spectroscopic techniques.
Wesley Y. Yoshida (1265682) +4 more
core +1 more source
Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies
Advanced Science, Volume 13, Issue 38, 9 July 2026.In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang +4 more
wiley +1 more source
Plitidepsin Has a Safe Cardiac Profile: A Comprehensive Analysis
Marine Drugs, 2011 Plitidepsin is a cyclic depsipeptide of marine origin in clinical development in cancer patients. Previously, some depsipeptides have been linked to increased cardiac toxicity.
Carmen Kahatt +9 more
doaj +1 more source