Results 21 to 30 of about 3,176 (160)
Unprecedented Antimicrobial and Cytotoxic Polyketides from Cultures of Diaporthe africana sp. nov.
Journal of Fungi, 2023 Four unprecedented polyketides named isoprenylisobenzofuran B (2), isoprenylisobenzofuran C1/C2 (3), diaporisoindole F1/F2 (4), and isochromophilonol A1/A2 (7) were isolated from ethyl acetate extracts of the newly described endophytic fungus Diaporthe ...
Blondelle Matio Kemkuignou +4 more
doaj +1 more source
SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
PLoS ONE, 2016 In order to expand the repertoire of antifungal compounds a novel, high-throughput phenotypic drug screen targeting fungal phosphatidylserine (PS) synthase (Cho1p) was developed based on antagonism of the toxin papuamide A (Pap-A).
Chelsi D Cassilly +6 more
doaj +1 more source
Characterizing the Anti-HIV Activity of Papuamide A
Marine Drugs, 2008 Papuamide A is representative of a class of marine derived cyclic depsipeptides, reported to have cytoprotective activity against HIV-1 in vitro. We show here that papuamide A acts as an entry inhibitor, preventing human immunodeficiency virus infection ...
Louis R. Barrows +2 more
doaj +1 more source
Bioactivities of Lyngbyabellins from Cyanobacteria of Moorea and Okeania Genera
Molecules, 2020 Cyanobacteria are reported as rich sources of secondary metabolites that provide biological activities such as enzyme inhibition and cytotoxicity. Ten depsipeptide derivatives (lyngbyabellins) were isolated from a Malaysian Moorea bouillonii and a Red ...
Imam Fathoni +9 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2012 The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from
Friederike I. Nollmann +6 more
doaj +1 more source
Frontiers in Fungal Biology, 2023 KK-1, a cyclic depsipeptide with 10 residues produced by a filamentous fungus Curvularia clavata BAUA-2787, is a promising pesticide active compound with high activity against many plant pathogens, especially Botrytis cinerea.
Shigenari Yamaguchi +10 more
doaj +1 more source
A cyclic carbo-isosteric penta-depsipeptide: cyclo(Phe1–d-Ala2–Gly3–Phe4–APO5)
Acta Crystallographica Section E: Crystallographic Communications, 2015 The title compound, cyclo(Phe1–d-Ala2–Gly3–Phe4–APO5), C26H32N4O5, is the minor diastereoisomer of a cyclic penta-peptidomimetic analogue containing a novel 2-aminopropyl lactone (APO) motif, which displays the same number of atoms as the native amino ...
Stéphanie M. Guéret, Trixie Wagner
doaj +1 more source
Frontiers in Chemistry, 2020 The cyclic depsipeptide FR900359 (FR) isolated from the plant Ardisia crenata and produced by endosymbiotic bacteria acts as a selective Gq protein inhibitor.
Markus Kuschak +13 more
doaj +1 more source
mSystems, 2020 Antibiotics have served humankind through their use in modern medicine as effective treatments for otherwise fatal bacterial infections. Teixobactin is a first member of newly discovered natural antibiotics that was recently identified from a hitherto ...
Maytham Hussein +10 more
doaj +3 more sources
Total Synthesis of Cyclodepsipeptide Xylaroamide A
ChemistryCyclodepsipeptides constitute a structurally diverse class of natural products composed of amino acid and hydroxy acid residues interconnected through both amide and ester bonds.
Rongping Wu +8 more
doaj +1 more source