Results 31 to 40 of about 3,874 (203)
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin
Marine Drugs, 2013 Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as “head-to-side-chain” cyclodepsipeptides, have been isolated and characterized.
Marta Pelay-Gimeno +2 more
doaj +1 more source
Frontiers in Catalysis, 2023 In nonribosomal peptide synthesis, condensation (C) domains are key catalytic domains that most commonly link carrier protein bound substrates to form peptides or depsipeptides.
Y. T. Candace Ho +28 more
doaj +1 more source
CHIMIA, 1983 Synthesis of phosphorous analogues of tri- and tetra-depsipeptides 4 involving the Passerini reaction of diethylisocyanmethylphosphonate 3 with carbonyl compounds 2 and N-protected glycine 1 is reported.
Janusz Rachoń
doaj +1 more source
Salinamides, Antiinflammatory Depsipeptides from a Marine Streptomycete
, 2016 In addition to the previously reported antiinflammatory agents salinamides A and B from the marine isolate Streptomyces sp. CNB-091, three minor peptides are described.
William Fenical (48035) +5 more
core +2 more sources
A New Depsipeptide Antibiotic, Variapeptin [PDF]
Agricultural and Biological Chemistry, 1990 A culture similar to Streptomyces variabilis was found to produce a novel cyclic hexadepsipeptide antibiotic named variapeptin. Variapeptin is structurally related to azinothricin, A83586C, and citropeptin. The antibiotic was active against Gram-positive bacteria and showed cytotoxic activity against mammalian cells.
NAKAGAWA, Masaya +3 more
openaire +3 more sources
Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry. [PDF]
, 2015 Flow chemistry has been successfully integrated into the synthesis of a series of cyclooligomeric depsipeptides of three different ring sizes including the natural products beauvericin (1 a), bassianolide (2 b) and enniatin C (1 b).
Zoe E. Wilson +3 more
core +3 more sources
Synthetic strategies of phosphonodepsipeptides
Beilstein Journal of Organic Chemistry, 2021 Phosphonodepsipeptides are phosphorus analogues of depsipeptides and phosphonate-linked analogues of naturally occurring peptides. They are more stable than phosphonopeptides and have been widely applied as enzyme inhibitors, haptens for the production ...
Jiaxi Xu
doaj +1 more source
Marine Drugs, 2023 This study aimed to elucidate the structural congeners of natural izenamides A, B, and C (1–3) responsible for cathepsin D (CTSD) inhibition. Structurally modified izenamides were synthesized and biologically evaluated, and their biologically important ...
Hyun Su Kim +6 more
doaj +1 more source
Synthesis of 16-membered cyclic depsipeptides via direct amide cyclization [PDF]
, 2000 The 2,2-disubstituted 2H-azirin-3-amines 5 (3-amino-2H-azirines) were used as synthons for alpha,alpha-disubstituted alpha-amino acids in the preparation of 16-membered cyclic depsipeptides 13.
Linden, Anthony; https://orcid.org/ +25 more
core +1 more source
Molecules, 2019 The first total syntheses of izenamides A, B, and C, which are depsipeptides inhibitor of cathepsin D, were accomplished. In addition, the stereochemistry of izenamide B was confirmed by our syntheses.
Changjin Lim
doaj +1 more source