Marine Drugs, 2023 This study aimed to elucidate the structural congeners of natural izenamides A, B, and C (1–3) responsible for cathepsin D (CTSD) inhibition. Structurally modified izenamides were synthesized and biologically evaluated, and their biologically important ...
Hyun Su Kim +6 more
doaj +1 more source
Depsipeptide substrates for sortase-mediated N-terminal protein ligation [PDF]
, 2014 Technologies that allow the efficient chemical modification of proteins under mild conditions are widely sought after. Sortase-mediated peptide ligation provides a strategy for modifying the N or C terminus of proteins. This protocol describes the use of
AJ Link +27 more
core +1 more source
Engineering of Aspergillus niger for the production of secondary metabolites [PDF]
, 2014 Background: Filamentous fungi can each produce dozens of secondary metabolites which are attractive as therapeutics, drugs, antimicrobials, flavour compounds and other high-value chemicals.
Boecker, Simon +7 more
core +1 more source
Molecules, 2019 The first total syntheses of izenamides A, B, and C, which are depsipeptides inhibitor of cathepsin D, were accomplished. In addition, the stereochemistry of izenamide B was confirmed by our syntheses.
Changjin Lim
doaj +1 more source
Protozoan-induced regulation of cyclic lipopeptide biosynthesis Is an effective predation defense mechanism for Pseudomonas fluorescens [PDF]
, 2009 Environmental bacteria are exposed to a myriad of biotic interactions that influence their function and survival. The grazing activity of protozoan predators significantly impacts the dynamics, diversification, and evolution of bacterial communities in ...
Bruijn, I., de +3 more
core +3 more sources
Multicomponent synthesis of hydrazino depsipeptides [PDF]
RSC Advances, 2016 Multicomponent reactions (MCRs) offer numerous advantages over traditional sequential reactions for the synthesis of diverse structurally demanding compounds. Isocynide-based MCRs, particularly Passerini and Ugi reactions, are of special importance, because they provide peptide-like compounds able to mimic structure and/or function of natural peptides ...
Barić, Danijela, Jerić, Ivanka
openaire +3 more sources
Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. [PDF]
, 2013 The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series.
A. D. Rodriguez +3 more
core +2 more sources
Total Synthesis of the Depsipeptide FR‐901375. [PDF]
ChemInform, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Yanping, Chen +4 more
openaire +2 more sources
Picocyanobacteria From a Clade Of Marine Cyanobium Revealed Bioactive Potential Against Microalgae, Bacteria, And Marine [PDF]
, 2015 The production of bioactive compounds either toxic or with pharmacological applications by cyanobacteria is well established. However, picoplanktonic forms within this group of organisms have rarely been studied in this context.
Barreiro, Aldo +6 more
core +1 more source
Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A
Angewandte Chemie International Edition, EarlyView.Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham +11 more
wiley +1 more source