Results 41 to 50 of about 3,583 (208)
Molecules, 2019 The first total syntheses of izenamides A, B, and C, which are depsipeptides inhibitor of cathepsin D, were accomplished. In addition, the stereochemistry of izenamide B was confirmed by our syntheses.
Changjin Lim
doaj +1 more source
Engineered Biosynthesis and Anticancer Studies of Ring-Expanded Antimycin-Type Depsipeptides. [PDF]
ACS Synth BiolRespirantins are 18-membered antimycin-type depsipeptides produced by Streptomyces sp. and Kitasatospora sp. These compounds have shown extraordinary anticancer activities against a panel of cancer cell lines with nanomolar levels of IC50 values. However,
Hu Z +6 more
europepmc +3 more sources
Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
Chemistry – A European Journal, EarlyView.ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source
Transcription inhibition by the depsipeptide antibiotic salinamide A [PDF]
eLife, 2014 We report that bacterial RNA polymerase (RNAP) is the functional cellular target of the depsipeptide antibiotic salinamide A (Sal), and we report that Sal inhibits RNAP through a novel binding site and mechanism. We show that Sal inhibits RNA synthesis in cells and that mutations that confer Sal-resistance map to RNAP genes.
Degen, David +12 more
openaire +4 more sources
Chemistry – A European Journal, EarlyView.Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt +3 more
wiley +1 more source
Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.
, 2007 Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2).
Mentel, Renate +6 more
core +1 more source
Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.A stiff‐stilbene‐based transmembrane anion transporter is isomerized by energy transfer from a ruthenium tris(bipyridyl) photosensitizer in the lipid bilayer. This sensitized isomerization allows activation of chloride transport using visible instead of UV light, without the need to chemically modify the stiff‐stilbene photoswitch.
Julia Villalva +6 more
wiley +2 more sources
Solid-Phase Synthesis of Cyclic Depsipeptides Containing a Tyrosine Phenyl Ester Bond
, 2016 The first solid-phase strategy for the synthesis of cyclic depsipeptides containing a phenyl ester linkage in their structure is described. The key steps of the synthesis were the formation of the phenyl ester bond and the on-resin head-to-side-chain ...
Kristy Vogels (2918675) +4 more
core +2 more sources
Absolute Stereochemistry of the β-Hydroxy Acid Unit in Hantupeptins and Trungapeptins
Natural Product Communications, 2016 The β-hydroxy/amino acid unit is a common structural feature of many bioactive marine cyanobacterial depsipeptides. In this study, the absolute stereochemistry of the β-hydroxy acid moieties in hantupeptins and trungapeptins were determined through their
Deepak Kumar Gupta +3 more
doaj +1 more source
Journal of Fungi, 2021 Fungi have been assured to be one of the wealthiest pools of bio-metabolites with remarkable potential for discovering new drugs. The pathogenic fungi, Fusarium oxysporum affects many valuable trees and crops all over the world, producing wilt.
Sabrin R. M. Ibrahim +4 more
doaj +1 more source