Results 21 to 30 of about 3,583 (208)

A New Depsipeptide Antibiotic, Variapeptin [PDF]

Agricultural and Biological Chemistry, 1990
A culture similar to Streptomyces variabilis was found to produce a novel cyclic hexadepsipeptide antibiotic named variapeptin. Variapeptin is structurally related to azinothricin, A83586C, and citropeptin. The antibiotic was active against Gram-positive bacteria and showed cytotoxic activity against mammalian cells.
NAKAGAWA, Masaya, HAYAKAWA, Yoichi, ADACHI, Kazuyoshi, SETO, Haruo   +3 more
openaire   +3 more sources

Zhaoshumycins A and B, Two Unprecedented Antimycin-Type Depsipeptides Produced by the Marine-Derived Streptomyces sp. ITBB-ZKa6

Marine Drugs, 2021
Marine actinomycetes are prolific chemical sources of complex and novel natural products, providing an excellent chance for new drug discovery. The chemical investigation of the marine-derived Streptomyces sp.
Zhikai Guo, Shiying Ma, Salman Khan, Hongjie Zhu, Bo Zhang, Shiqing Zhang, Ruihua Jiao   +6 more
doaj   +1 more source

A new depsipeptide antibiotic, citropeptin. [PDF]

Agricultural and Biological Chemistry, 1990
An actinomycete identified as Streptomyces flavidovirens was found to produce a new cyclic hexadepsipeptide antibiotic, designated citropeptin. Citropeptin showed antitumor activity against P388 murine leukemia.
HAYAKAWA, Yoichi, NAKAGAWA, Masaya, TODA, Yoichiro, SETO, Haruo   +3 more
openaire   +3 more sources

Solid-Phase Synthesis of Head to Side-Chain Tyr-Cyclodepsipeptides Through a Cyclative Cleavage From Fmoc-MeDbz/MeNbz-resins

Frontiers in Chemistry, 2020
Cyclic depsipeptides constitute a fascinating class of natural products. Most of them are characterized by an ester formed between the β-hydroxy function of Ser/Thr -and related amino acids- and the carboxylic group of the C-terminal amino acid.
Gerardo A. Acosta, Gerardo A. Acosta, Gerardo A. Acosta, Gerardo A. Acosta, Laura Murray, Laura Murray, Miriam Royo, Miriam Royo, Beatriz G. de la Torre, Beatriz G. de la Torre, Fernando Albericio, Fernando Albericio, Fernando Albericio, Fernando Albericio, Fernando Albericio   +14 more
doaj   +1 more source

Total Syntheses of Colletopeptide A and Colletotrichamide A

Molecules, 2023
The first total syntheses of cyclic depsipeptides colletopeptide A and colletotrichamide A, have been accomplished. The key advanced intermediate, a cyclic tridepsipeptide derivative, was constructed using a sequence of transformations that features ...
Jing Chen, Yangyang Jiang, Jialei Yan, Chao Xu, Tao Ye   +4 more
doaj   +1 more source

Total Synthesis of Pagoamide A

Molecules, 2021
The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous ...
Fusong Wu, Jie Yu, Jiawei Meng, Yian Guo, Tao Ye   +4 more
doaj   +1 more source

Protection-Free Strategy for the Synthesis of Boro-Depsipeptides in Aqueous Media under Microwave-Assisted Conditions

Molecules, 2022
In this report, 19 boron-containing depsipeptides were synthesized via microwave-assisted Passerini three-component reaction (P-3CR) in an aqueous environment.
Shuo-Bei Qiu, Pei-Yao Liu, Bo-Cheng Wang, Pin-Rui Chen, Jing-Han Xiao, Ting-Yu Hsu, Kuan-Lin Pan, Zhi-Yin Lai, Yi-Wei Chen, Ying-Chuan Chen, Jen-Kun Chen, Po-Shen Pan   +11 more
doaj   +1 more source

Total Synthesis of the Depsipeptide FR‐901375. [PDF]

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Yanping, Chen, Celine, Gambs, Yoshito, Abe, Paul, Wentworth, Kim D, Janda   +4 more
openaire   +2 more sources

Preclinical Assessment of a 68Ga-DOTA-Functionalized Depsipeptide as a Radiodiagnostic Infection Imaging Agent

Molecules, 2017
The study assessed a radiolabeled depsipeptide conjugate (68Ga-DOTA-TBIA101) for its potential as an imaging agent targeting infection or infection-associated inflammation. 68Ga-labeled DOTA-TBIA101 imaging was performed in (NZR1) healthy rabbits; (NZR2)
Thomas Ebenhan, Botshelo Brenda Mokaleng, Jacobus Daniel Venter, Hendrik Gert Kruger, Jan Rijn Zeevaart, Mike Sathekge   +5 more
doaj   +1 more source

Synthesis of cyclic depsipeptides under direct amide cyclization conditions [PDF]

, 2005
This work describes the use of the "direct amide cyclization" (DAC) of dipeptides which contain β-, γ-, or δ-hydroxy acids, obtained by the reaction of the corresponding hydroxy acids with 3-amino-2H-azirines, the so-called "azirine/oxazolone" method ...
Iliev, Boyan Iliev
core   +1 more source