Results 11 to 20 of about 2,854 (178)

Synthesis of Depsipeptides via Isocyanide-Based Consecutive Bargellini–Passerini Multicomponent Reactions

SynOpen, 2021
An efficient and straightforward approach has been established for the preparation of a new class of depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions.
Hassan Farhid, Mohammad Mahdi Rostami, Ahmad Shaabani, Behrouz Notash   +3 more
doaj   +1 more source

Exploring the sequence space of unknown oligomers and polymers

Cell Reports Physical Science, 2021
Summary: The characterization of the chemistry of life on earth has been facilitated by developments in analysis and sequencing of bio-oligomers using tandem mass spectrometry (MS/MS).
David Doran, Emma Clarke, Graham Keenan, Emma Carrick, Cole Mathis, Leroy Cronin   +5 more
doaj   +1 more source

Multicomponent synthesis and photophysical study of novel α,β-unsaturated carbonyl depsipeptides and peptoids

Frontiers in Chemistry, 2023
Multicomponent reactions were performed to develop novel α,β-unsaturated carbonyl depsipeptides and peptoids incorporating various chromophores such as cinnamic, coumarin, and quinolines.
Ricelia González, Juliana Murillo-López, Walter Rabanal-León, Luis Prent-Peñaloza, Odette Concepción, Pedro Olivares, Yorley Duarte, Alexander F. de la Torre, Margarita Gutiérrez, Julio Caballero   +9 more
doaj   +1 more source

Peptides from Marine-Derived Fungi: Chemistry and Biological Activities

Marine Drugs, 2023
Marine natural products are well-recognized as potential resources to fill the pipeline of drug leads to enter the pharmaceutical industry. In this circumstance, marine-derived fungi are one of the unique sources of bioactive secondary metabolites due to
Salar Hafez Ghoran, Fatemeh Taktaz, Emília Sousa, Carla Fernandes, Anake Kijjoa   +4 more
doaj   +1 more source

Depsipeptides Targeting Tumor Cells: Milestones from In Vitro to Clinical Trials

Molecules, 2023
Cancer is currently considered one of the most threatening diseases worldwide. Diet could be one of the factors that can be enhanced to comprehensively address a cancer patient’s condition.
Plinio A. Trinidad-Calderón, Carlos Daniel Varela-Chinchilla, Silverio García-Lara   +2 more
doaj   +1 more source

A Survey of Didemnin Depsipeptide Production in Tistrella

Marine Drugs, 2023
As one of the first families of marine natural products to undergo clinical trials, the didemnin depsipeptides have played a significant role in inspiring the discovery of marine drugs.
Robert J. Stankey, Don Johnson, Brendan M. Duggan, David A. Mead, James J. La Clair   +4 more
doaj   +1 more source

A Bidirectional Permeability Assay for beyond Rule of 5 Compounds

Pharmaceutics, 2021
Bidirectional permeability measurement with cellular models grown on Transwell inserts is widely used in pharmaceutical research since it not only provides information about the passive permeability of a drug, but also about transport proteins involved ...
Yunhai Cui, Cyril Desevaux, Ines Truebenbach, Peter Sieger, Klaus Klinder, Alan Long, Achim Sauer   +6 more
doaj   +1 more source

A contribution to the nomenclature of depsipeptides [PDF]

Journal of Peptide Science, 2003
AbstractDepsipeptides, also called peptolides, are a class of peptidic compounds in which an amide bond has been replaced with an ester bond. The literature does not clearly display rules for the nomenclature of such compounds. Here a method is proposed to transcribe drawn depsipeptide structures in one‐line text.
Sorin V, Filip, Florine, Cavelier
openaire   +2 more sources

Zhaoshumycins A and B, Two Unprecedented Antimycin-Type Depsipeptides Produced by the Marine-Derived Streptomyces sp. ITBB-ZKa6

Marine Drugs, 2021
Marine actinomycetes are prolific chemical sources of complex and novel natural products, providing an excellent chance for new drug discovery. The chemical investigation of the marine-derived Streptomyces sp.
Zhikai Guo, Shiying Ma, Salman Khan, Hongjie Zhu, Bo Zhang, Shiqing Zhang, Ruihua Jiao   +6 more
doaj   +1 more source

Solid-Phase Synthesis of Head to Side-Chain Tyr-Cyclodepsipeptides Through a Cyclative Cleavage From Fmoc-MeDbz/MeNbz-resins

Frontiers in Chemistry, 2020
Cyclic depsipeptides constitute a fascinating class of natural products. Most of them are characterized by an ester formed between the β-hydroxy function of Ser/Thr -and related amino acids- and the carboxylic group of the C-terminal amino acid.
Gerardo A. Acosta, Gerardo A. Acosta, Gerardo A. Acosta, Gerardo A. Acosta, Laura Murray, Laura Murray, Miriam Royo, Miriam Royo, Beatriz G. de la Torre, Beatriz G. de la Torre, Fernando Albericio, Fernando Albericio, Fernando Albericio, Fernando Albericio, Fernando Albericio   +14 more
doaj   +1 more source