Results 61 to 70 of about 2,854 (178)
Marine Drugs, 2012 Lagunamides A (<strong>1</strong>) and B (<strong>2</strong>) are potent cytotoxic cyclic depsipeptides isolated from the filamentous marine cyanobacterium, <em>Lyngbya majuscula</em>, from Pulau Hantu, Singapore ...
David Tai Leong +3 more
doaj +1 more source
Activating hidden signals by mimicking cryptic sites in a synthetic extracellular matrix
Nature Communications, 2023 Cryptic sites are short signaling peptides buried within the native extracellular matrix (ECM). Enzymatic cleavage of an ECM protein reveals these hidden peptide sequences, which interact with surface receptors to control cell behavior.
Yumeng Zhu +5 more
doaj +1 more source
Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.An Epicoccum fungus was isolated from gut of larvae of the butterfly Dione juno juno that feeds intensively on leaves of Passifloras. This fungus produces hydroxyanthraquinones that moderately inhibits growth of some Bacillus that coexist with the fungus in the insect gut, suggesting that it is probably important for microbial embalance in gut flora ...
Jessica Teixeira Dias +5 more
wiley +1 more source
Vacuolization as a Novel Approach to Cancer Therapy
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak +9 more
wiley +1 more source
The Journal of Pathology, Volume 269, Issue 2, Page 149-163, June 2026.Abstract The conceptualization of mitochondria, previously restricted to their function as cellular ‘powerhouses’, has evolved to recognize their function as central coordinating hubs for the orchestration of cancer cell metabolism, signaling, and fate determination.
Woo Hyun Park
wiley +1 more source
Neuroendocrine tumours through an epigenetic lens: Emerging insights for diagnosis and treatment
Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.Abstract Neuroendocrine tumours (NETs) are well‐differentiated epithelial neuroendocrine neoplasms that frequently develop in the small intestine, pancreas, and lungs. NETs originate from neuroendocrine cells specialized in hormone secretion implicated in a number of physiological processes.
Victoria Jacquot +4 more
wiley +1 more source
Marine Drugs, 2019 Lagunamide D, a new cytotoxic macrocyclic depsipeptide, was discovered from a collection of marine cyanobacteria from Loggerhead Key in the Dry Tortugas, Florida.
Danmeng Luo +4 more
doaj +1 more source
Marine Drugs, 2009 Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8–10 (1–3).
Hendrik Luesch +3 more
doaj +1 more source
Acta Pharmaceutica Sinica BIn the omics era, confident high-throughput analytical tools are crucial for the efficient identification of metabolites. Here, we present DeepHalo, a deep learning-integrated and hierarchically optimized workflow designed for high-throughput exploration
Shanshan Chang +15 more
doaj +1 more source
Cyclodepsipeptides from Marine Sponges: Natural Agents for Drug Research
Marine Drugs, 2010 A number of natural products from marine sponges, such as cyclodepsipeptides, have been identified. The structural characteristics of this family of cyclic peptides include various unusual amino acid residues and unique N-terminal polyketide-derived ...
Rosa Lemmens-Gruber +1 more
doaj +1 more source