Results 71 to 80 of about 3,583 (208)
The Journal of Pathology, Volume 269, Issue 2, Page 149-163, June 2026.Abstract The conceptualization of mitochondria, previously restricted to their function as cellular ‘powerhouses’, has evolved to recognize their function as central coordinating hubs for the orchestration of cancer cell metabolism, signaling, and fate determination.
Woo Hyun Park
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Synthesis of cyclic depsipeptides and peptides via direct amide cyclization
, 1997 The 2,2-disubstituted 2H-azirin-3-amines 7 (2,2-disubstituted 3-amino-2H-azirines) were used as amino-acid synthons in the preparation of medium-sized cyclic depsipeptides and peptides derived from salicylic acids 6 and anthranilic acid 19, respectively (
Heimgartner, Heinz, Villalgordo, Jose M
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Marine Drugs, 2012 Lagunamides A (<strong>1</strong>) and B (<strong>2</strong>) are potent cytotoxic cyclic depsipeptides isolated from the filamentous marine cyanobacterium, <em>Lyngbya majuscula</em>, from Pulau Hantu, Singapore ...
David Tai Leong +3 more
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Biosynthesis of the 15-Membered Ring Depsipeptide Neoantimycin [PDF]
ACS Chemical Biology, 2018 Antimycins are a family of natural products possessing outstanding biological activities and unique structures, which have intrigued chemists for over a half century. Of particular interest are the ring-expanded antimycins that show promising anticancer potential and whose biosynthesis remains uncharacterized. Specifically, neoantimycin and its analogs
Skyrud, W +5 more
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Neuroendocrine tumours through an epigenetic lens: Emerging insights for diagnosis and treatment
Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.Abstract Neuroendocrine tumours (NETs) are well‐differentiated epithelial neuroendocrine neoplasms that frequently develop in the small intestine, pancreas, and lungs. NETs originate from neuroendocrine cells specialized in hormone secretion implicated in a number of physiological processes.
Victoria Jacquot +4 more
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, 2014 Citation: 'depsipeptides' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.D01604 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for commercial
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Activating hidden signals by mimicking cryptic sites in a synthetic extracellular matrix
Nature Communications, 2023 Cryptic sites are short signaling peptides buried within the native extracellular matrix (ECM). Enzymatic cleavage of an ECM protein reveals these hidden peptide sequences, which interact with surface receptors to control cell behavior.
Yumeng Zhu +5 more
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Multi‐Targeting Non‐Specific Genome Engineering in Bacteria
Advanced Science, Volume 13, Issue 25, 4 May 2026.In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Runze Sun +7 more
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Journal of Mass Spectrometry, Volume 61, Issue 5, May 2026.ABSTRACT Cyclic peptides occupy a structurally dynamic region of chemical space, where function often arises from ensembles rather than a single dominant fold. Closed backbones, frequent N‐methylation, heteroatoms, unnatural amino acids, and a strong propensity for metal coordination create dense conformational and coordination landscapes that ...
Emmanuel Nkyaagye +2 more
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Macrocyclic Peptides: Chemistry and Biology of Stapled and Depsipeptides
, 2023 Macrocyclic peptides have been identified as key backbones in several biologically active compounds. They have been considered as great inspiration in the development of novel cyclic scaffolds in medicinal chemistry, notably in the introduction of α ...
Paquette, André
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