Marine Drugs, 2017 Bioassay-guided isolation of the lipophilic extract of Trichodesmium thiebautii bloom material led to the purification and structure characterization of two new hybrid polyketide-non-ribosomal peptide (PKS-NRPS) macrocyclic compounds, tricholides A and B
Matthew J. Bertin +7 more
doaj +1 more source
SB-224289 Protects Against Theopapuamide, but Not Other Depsipeptides.
, 2016 A. The structure of several depsipeptides are shown. For each of these compounds, 1x104 cells/ml were treated with serially diluted concentrations of SB-224289 (SB) and were incubated for 3 hours at 37°C. Following this incubation, B. 3 μg/ml valinomycin
Marcus M. Maddox (520204) +6 more
core +1 more source
Total Syntheses and Configuration Assignments of JBIR-06 and Related Depsipeptides
, 2019 The first total syntheses of JBIR-06 and two analogous depsipeptides, 12-membered antimycin-class antibiotics, have been accomplished via Shiina macrolactonization. Comparison of the spectroscopic data of the synthesized compounds with those reported for
Hikaru Ogawa (6276827) +5 more
core +1 more source
Cyclic Carbo-Isosteric Depsipeptides and Peptides as a Novel Class of Peptidomimetic
, 2014 A novel and highly efficient cyclization method has been developed to access a new class of cyclic carbo-isosteric depsipeptides and peptides as drug-like molecules.
Roth, Hans-Joerg +2 more
core +1 more source
Cavomycins A–C, Linear Oligomer Depsipeptides from an Annelid-Associated Streptomyces cavourensis
Three unique linear oligomeric depsipeptides, designated as cavomycins A–C (1–3), were identified from Streptomyces cavourensis, a gut bacterium associated with the annelid Paraleonnates uschakovi.
Scott Franzblau (2272048) +19 more
core +1 more source
Ionophoric Activity of Cyclic Depsipeptides from Beauveria bassiana
, 2022 Beauvericin and bassianolide are cyclodepsipeptides produced as secondary metabolites by the fungus Beauveria bassiana. Depsipeptides are molecules of high interest, since some of them show high potential for pharmaceutical applications.
Theuerkauf, Marie
core +1 more source
Beilstein Journal of Organic ChemistryDrug conjugates using toxic payloads are a promising approach for selectively combating cancer while sparing healthy tissue. The lack of highly cytotoxic and at the same time selective therapeutics against cancer is an ongoing challenge.
Thomas Schachtsiek +5 more
doaj +1 more source
Cyclic Carbo-Isosteric Depsipeptides and Peptides as a Novel Class of Peptidomimetics
, 2016 A novel and highly efficient cyclization method has been developed to access a new class of cyclic carbo-isosteric depsipeptides and carbo-isosteric peptides.
Hans-Jörg Roth (1508320) +2 more
core +1 more source
EF-P inhibits ribosomal α-hydroxy acid incorporation: strategic tRNA body selection for co-incorporating α-hydroxy acids and nonproteinogenic amino acids into depsipeptides. [PDF]
RNAKatoh T.
europepmc +1 more source
Total Synthesis of Marine Natural Product Sunshinamide via Macrolactonization. [PDF]
Arch Pharm (Weinheim)Lu Y +6 more
europepmc +1 more source