Results 91 to 100 of about 5,584 (214)

Biosurfactants: potential applications in medicine [PDF]

, 2006
The use and potential commercial application of biosurfactants in the medical field has increased during the past decade. Their antibacterial, antifungal and antiviral activities make them relevant molecules for applications in combating many diseases ...
Banat, Ibrahim M., Oliveira, Rosário, Rodrigues, L. R., Teixeira, J. A.   +3 more
core   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Payload‐Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure–Function Relationships

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Polymeric carriers provide versatile platforms for nucleic acid delivery. This review introduces a novel perspective inspired by protein structural organization to explore structure–function relationships of polymeric carriers, highlighting requirements of different nucleic acid payloads.
Hanieh Moradian, Charlotte Maeve Dunne, Manfred Gossen, Matthias Hartlieb   +3 more
wiley   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Isolation, Structure Elucidation and Biological Evaluation of Lagunamide D: A New Cytotoxic Macrocyclic Depsipeptide from Marine Cyanobacteria

Marine Drugs, 2019
Lagunamide D, a new cytotoxic macrocyclic depsipeptide, was discovered from a collection of marine cyanobacteria from Loggerhead Key in the Dry Tortugas, Florida.
Danmeng Luo, Masteria Y. Putra, Tao Ye, Valerie J. Paul, Hendrik Luesch   +4 more
doaj   +1 more source

The V‐Shaped Hamilton Receptors: A Paradigmatic Multipurpose Scaffold

ChemistryOpen, Volume 15, Issue 1, January 2026.
This manuscript explores the historical context and significance of molecular recognition in relation to Hamilton‐type receptors. It concludes with a discussion on future prospects for the development of novel functionalized Hamilton‐type receptors. It is hoped that this collection will offer new insights and directions for the supramolecular chemistry
Shafieq Ahmad Wagay, Rashid Ali
wiley   +1 more source

Lyngbyastatins 8–10, Elastase Inhibitors with Cyclic Depsipeptide Scaffolds Isolated from the Marine Cyanobacterium Lyngbya semiplena

Marine Drugs, 2009
Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8–10 (1–3).
Hendrik Luesch, Valerie J. Paul, Kanchan Taori, Jason C. Kwan   +3 more
doaj   +1 more source

A83586C, a new depsipeptide antibiotic.

The Journal of Antibiotics, 1988
A culture identified as Streptomyces karnatakensis was found to produce a novel cyclic hexadepsipeptide antibiotic designated A83586C. The structure was elucidated by X-ray crystallography, and full 1H and 13C NMR assignments are reported. The absolute configuration was confirmed by the detection of D-threonine in the acid hydrolysate of A83586C ...
T A, Smitka, J B, Deeter, A H, Hunt, F P, Mertz, R M, Ellis, L D, Boeck, R C, Yao   +6 more
openaire   +3 more sources

Marine Sponge Derived Natural Products between 2001 and 2010: Trends and Opportunities for Discovery of Bioactives [PDF]

, 2014
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).Abstract: Marine sponges belonging to the phylum Porifera (Metazoa ...
Franco, Christopher Milton, Lei, Jie, Mehbub, Mohammad Ferdous, Zhang, Wei   +3 more
core   +2 more sources

Robust Synthesis of Prebiotic Precursors in Drying Reactions of Amino Acids and Keto Acids

ChemSystemsChem, Volume 8, Issue 1, January 2026.
Drying conditions drive reactions between amino acids and keto acids, generating a wide variety of small, reactive species, highlighting for the first time the potential significance of drying reactions in proto‐metabolism on early Earth. Condensation‐dehydration reactions are critical to both metabolism and polymerization in extant biology, and their ...
Eliav Marland, Gal Lipson, Rotem Edri, Or Cohen, Aikomari Guzman‐Martinez, Ori Shalev, César Menor Salvan, Moran Frenkel‐Pinter   +7 more
wiley   +1 more source