Results 101 to 110 of about 3,583 (208)

Papuamides E and F, cytotoxic depsipeptides from the marine sponge Melophlus sp.

, 2011
Two known papuamides C (1) and D (2) together with two new depsipeptides, papuamides E (3) and F (4), were isolated from an undescribed sponge of the genus Melophlus collected in the Solomon Islands. The planar structures of the compounds were elucidated
Aalbersberg, William, Feussner, Klaus-D., Prasad, Pritesh, Van Wagoner, Ryan M.   +3 more
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Izenamides A and B, Statine-Containing Depsipeptides, and an Analogue from a Marine Cyanobacterium

, 2018
Izenamides A, B, and C (1–3), new linear depsipeptides, were isolated from a taxonomically distinct marine cyanobacterium. Izenamides A and B contain a statine moiety [(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid] and inhibited the activity of ...
Yuki Kanamori (2862746), Shimpei Sumimoto (3116160), Shimpei Sumimoto, Kiyotake Suenaga (811759), Kiyotake Suenaga, Teruhiko Matsubara (709084), Toshinori Sato, Toshinori Sato (709087), Arihiro Iwasaki (1476136), Yuki Kanamori, Teruhiko Matsubara, Arihiro Iwasaki   +11 more
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Cryptophycin unit B analogues

Beilstein Journal of Organic Chemistry
Drug conjugates using toxic payloads are a promising approach for selectively combating cancer while sparing healthy tissue. The lack of highly cytotoxic and at the same time selective therapeutics against cancer is an ongoing challenge.
Thomas Schachtsiek, Jona Voss, Maren Hamsen, Beate Neumann, Hans-Georg Stammler, Norbert Sewald   +5 more
doaj   +1 more source

Revisiting N‑to‑O Acyl Shift for Synthesis of Natural Product-like Cyclic Depsipeptides

, 2016
Despite the prevalence of head-to-side chain threonine linkages in natural products, their incorporation has been underexplored in synthetic cyclic peptides. Herein we investigate a cyclic peptide scaffold able to undergo an N–O acyl rearrangement.
Yashar Abdollahian (1616242), Bhagyashree Khunte (1399660), Joshua Schwochert (1670326), Amit S. Kalgutkar (1585282), Chris Limberakis (1348395), Heather Eng (1670314), David A. Price (36138), Kathleen Farley (1710265), Michael J. Shapiro (1710271), Alan M. Mathiowetz (1348374), R. Scott Lokey (133725), Spiros Liras (1585273), Christopher Ahlbach (1710274), Cameron Pye (1710268)   +13 more
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(αMe)Hyv: Chemo-enzymatic synthesis, and preparation and preferred conformation of model depsipeptides

, 2002
By a chemo-enzymatic approach we performed a large-scale, stereoselective synthesis of the Cα-methylated α-hydroxy acid L-(αMe)Hyv. We also prepared model depsipeptides based on this sterically demanding residue in combination with the α-amino acids L ...
Formaggio F., Kaptein B., Peggion C., Mayrhofer H., Pochlauer P., Crisma M., Tomasini C., Barazza A., Toniolo C., Broxterman Q. B., Villa M.   +10 more
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Mirabamides A–D, Depsipeptides from the Sponge Siliquariaspongia mirabilis That Inhibit HIV-1 Fusion

, 2016
Four new cyclic depsipeptides termed mirabamides A–D (1–4) have been isolated from the marine sponge Siliquariaspongia mirabilis and shown to potently inhibit HIV-1 fusion.
Elena Gustchina (237584), Carole A. Bewley (237605), Michelle Kelly (109768), Alberto Plaza (1541617), Heather L. Baker (1307841)   +4 more
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Controlling production of brominated cyclic depsipeptides by Pseudoalteromonas maricaloris KMM 636(T)

, 2005
Aims: This study aims at evaluating the impact of the nutrient medium components on the in vitro production of the cytotoxic alterochromides. Methods and Results: The employment matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS ...
Sobolevskaya, M. P., Shevchenko, L. S., Smetanina, Olga E., Laatsch, Hartmut, Ivanova, Elena P., Dmitrenok, P. S., Kuznetsova, Tatyana A., Speitling, M., Elyakov, G. B.   +8 more
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South African actinobacteria: A treasure trove of novel bioactive metabolites for drug discovery

South African Journal of Science
Although South Africa is known as one of the most biodiverse countries in the world, based on its unique plants and animals, microorganisms have received much less attention.
Kojo S. Acquah, David W. Gammon, Denzil R. Beukes   +2 more
doaj   +1 more source

Preparation and conformational analysis of enantiomeric ferrocene depsipeptides with phenylalanine

Iako sudjeluju u izrazito važnim fiziološkim mehanizmima i kontroliraju gotovo sve vitalne funkcije u organizmu, peptidi nisu pogodi za primjenu u terapeutske svrhe, pa se različitim peptidomimetičkim modifikacijama nastoji prevladati njihova postojeća ...
Vučičević, Vita
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Synthesis and studies of biologically active peptides and depsipeptides

, 2005
EThOS - Electronic Theses Online ServiceGBUnited ...
Merryweather, Michael, Merryweather, M.
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