Cyclodepsipeptides from Marine Sponges: Natural Agents for Drug Research
Marine Drugs, 2010 A number of natural products from marine sponges, such as cyclodepsipeptides, have been identified. The structural characteristics of this family of cyclic peptides include various unusual amino acid residues and unique N-terminal polyketide-derived ...
Rosa Lemmens-Gruber +1 more
doaj +1 more source
Chemoenzymatic Synthesis of Cryptophycin Anticancer Agents by an Ester Bond-Forming Non-ribosomal Peptide Synthetase Module [PDF]
, 2011 Cryptophycins (Crp) are a group of cyanobacterial depsipeptides with activity against drug-resistant tumors. Although they have been shown to be promising, further efforts are required to return these highly potent compounds to the clinic through a new ...
Bolduc, Kyle L. +4 more
core +1 more source
Selective complexation of divalent cations by a cyclic α,β-peptoid hexamer: a spectroscopic and computational study [PDF]
, 2016 We describe the qualitative and quantitative analysis of the complexation properties towards cations of a cyclic peptoid hexamer composed of alternating α- and β-peptoid monomers, which bear exclusively chiral (S)-phenylethyl side chains (spe) that have ...
A. A. Edwards +68 more
core +2 more sources
A phylogenetic and evolutionary analysis of antimycin biosynthesis
, 2018 Streptomyces species and other Actinobacteria are ubiquitous in diverse environments worldwide and are the source of, or inspiration for, the majority of antibiotics.
Maddison +3 more
core +1 more source
Nonribosomal peptides, key biocontrol components for Pseudomonas fluorescens In5, isolated from a Greenlandic suppressive soil. [PDF]
, 2015 UnlabelledPotatoes are cultivated in southwest Greenland without the use of pesticides and with limited crop rotation. Despite the fact that plant-pathogenic fungi are present, no severe-disease outbreaks have yet been observed.
Dorrestein, Pieter C +6 more
core
Marine Drugs, 2017 Bioassay-guided isolation of the lipophilic extract of Trichodesmium thiebautii bloom material led to the purification and structure characterization of two new hybrid polyketide-non-ribosomal peptide (PKS-NRPS) macrocyclic compounds, tricholides A and B
Matthew J. Bertin +7 more
doaj +1 more source
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. [PDF]
, 2011 Backbone N-methylation is common among peptide natural products and has a substantial impact on both the physical properties and the conformational states of cyclic peptides.
Bauman, Jonathan N +16 more
core +1 more source
Corals as Source of Bacteria with Antimicrobial Activity [PDF]
, 2008 In this study we examined marine bacteria associated with different corals (Porites lutea, Galaxea fascicularis, Acropora sp. and Pavona sp.) collected from vicinity of Panjang island, Jepara, North Java Sea, Indonesia for their antimicrobial activities ...
Imhoff, J. F. (Johannes) +3 more
core
Beilstein Journal of Organic ChemistryDrug conjugates using toxic payloads are a promising approach for selectively combating cancer while sparing healthy tissue. The lack of highly cytotoxic and at the same time selective therapeutics against cancer is an ongoing challenge.
Thomas Schachtsiek +5 more
doaj +1 more source
Algal polyunsaturated fatty acids and effects on plankton ecology and other organisms [PDF]
, 2004 A review and discussion of the effects of algal polyunsaturated fatty acids (PUFAs) on phytoplankton and zooplankton ecology and their effects on other animal systems.
Ikawa, Miyoshi
core +1 more source