Results 51 to 60 of about 497 (160)

Neuroendocrine tumours through an epigenetic lens: Emerging insights for diagnosis and treatment

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Neuroendocrine tumours (NETs) are well‐differentiated epithelial neuroendocrine neoplasms that frequently develop in the small intestine, pancreas, and lungs. NETs originate from neuroendocrine cells specialized in hormone secretion implicated in a number of physiological processes.
Victoria Jacquot, Benjamin Chevalier, Thomas Walter, Benjamin Gibert, Maria Ouzounova   +4 more
wiley   +1 more source

The role of the cyclic depsipeptide rings in antibiotics.

The Journal of Antibiotics, 1985
The physical and biological roles of the cyclic depsipeptides of actinomycin, quinomycin and triostin antibiotic families are proposed by examining the crystal structures of d(GC)-actinomycin D and d(CGTACG)-triostin A. The analyses suggest that not only are DNA-amino acid hydrogen-bonding and chromophore-base pair stacking crucially important for DNA ...
openaire   +3 more sources

Characterizing the Anti-HIV Activity of Papuamide A

Marine Drugs, 2008
Papuamide A is representative of a class of marine derived cyclic depsipeptides, reported to have cytoprotective activity against HIV-1 in vitro. We show here that papuamide A acts as an entry inhibitor, preventing human immunodeficiency virus infection ...
Louis R. Barrows, Vicente Planelles, Cynthia D. Andjelic   +2 more
doaj   +1 more source

Cyclic Carbo-Isosteric Depsipeptides and Peptides as a Novel Class of Peptidomimetics

, 2016
A novel and highly efficient cyclization method has been developed to access a new class of cyclic carbo-isosteric depsipeptides and carbo-isosteric peptides.
Hans-Jörg Roth (1508320), Stéphanie M. Guéret (1837621), Peter Meier (1837624)   +2 more
core   +1 more source

SMALL DEPSIPEPTIDES AS SOLVENT GELATORS

, 1993
The formation of very thermostable gels with several solvents is reported for two cyclic depsipeptides of comparatively low molecular mass.
KELLOGG, RM, DEVRIES, EJ
core   +1 more source

Cytotoxic and Antibacterial Cyclodepsipeptides from an Endophytic Fungus Fusarium avenaceum W8

Molecules
Seven cyclic depsipeptides, including two new cyclic pentadepsipeptides avenamides A (1) and B (2), were isolated from a plant-derived fungus Fusarium avenaceum W8 by using the bioassay-guided fractionation method.
Zimo Wang, Bo Liu, Yanlei Wang, Yicen Xu, Hai Ma, Yi Sun   +5 more
doaj   +1 more source

Marine-derived Acremonium strain prioritization using untargeted metabolomics approach for the identification of cytotoxic cyclic depsipeptides

BMC Biotechnology
Background The Arctic environment, characterized by extreme conditions, hosts a largely untapped reservoir of fungal communities that have adapted to these harsh conditions by producing specialized bioactive secondary metabolites. Among these, Acremonium
Sailesh Maharjan, Johan Isaksson, Teppo Rämä, Kine Østnes Hansen, Jeanette Hammer Andersen, Espen Holst Hansen   +5 more
doaj   +1 more source

Cyanobacterial Allelochemicals But Not Cyanobacterial Cells Markedly Reduce Microbial Community Diversity

Frontiers in Microbiology, 2017
The freshwater cyanobacterium Phormidium sp. LEGE 05292 produces allelochemicals, including the cyclic depsipeptides portoamides, that influence the growth of heterotrophic bacteria, cyanobacteria, and eukaryotic algae.
Filipa Dias, Jorge T. Antunes, Jorge T. Antunes, Tiago Ribeiro, Joana Azevedo, Joana Azevedo, Vitor Vasconcelos, Vitor Vasconcelos, Pedro N. Leão   +8 more
doaj   +1 more source

Multi‐Targeting Non‐Specific Genome Engineering in Bacteria

Advanced Science, Volume 13, Issue 25, 4 May 2026.
In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Runze Sun, Ruixiang You, Yiwen Zhou, Huiyan He, Wenfang Wang, Xudong Qu, Yinhua Lu, Lei Li   +7 more
wiley   +1 more source

Linking molecular architecture to antibacterial functions: a chemical biology view of cyclic depsipeptides

Frontiers in Chemistry
Antimicrobial depsipeptides and cyclodepsipeptides represent a structurally diverse class of natural products that have gained renewed attention as both antibacterial agents and molecular tools to interrogate bacterial physiology.
Sachin Baravkar, Varsha J. Thombare, Varsha J. Thombare, Yuezhou Wu, Yuezhou Wu, Nitin A. Patil, Nitin A. Patil   +6 more
doaj   +1 more source