Results 71 to 80 of about 3,689 (198)

Synthesis of Peptides, Peptide Nucleic Acid Components, and Other Biogenic Compounds From a Three‐Component Prebiotic Mixture

Chemistry – A European Journal, Volume 32, Issue 9, 2 March 2026.
High‐energy proton irradiation of a formamide–diaminomaleonitrile–glycine system in the presence of meteorites produces a broad spectrum of biogenic compounds, including nucleobases, nucleosides, peptides, and nucleobase–peptide conjugates, highlighting a chemically plausible prebiotic network.
Bruno Mattia Bizzarri, Rosangela Santalucia, Eleonora Mancin, Mikhail Kapralov, Eugene Krasavin, Raffaele Saladino, Ernesto Di Mauro   +6 more
wiley   +1 more source

Cyanobacterial Allelochemicals But Not Cyanobacterial Cells Markedly Reduce Microbial Community Diversity

Frontiers in Microbiology, 2017
The freshwater cyanobacterium Phormidium sp. LEGE 05292 produces allelochemicals, including the cyclic depsipeptides portoamides, that influence the growth of heterotrophic bacteria, cyanobacteria, and eukaryotic algae.
Filipa Dias, Jorge T. Antunes, Jorge T. Antunes, Tiago Ribeiro, Joana Azevedo, Joana Azevedo, Vitor Vasconcelos, Vitor Vasconcelos, Pedro N. Leão   +8 more
doaj   +1 more source

Production of Induced Secondary Metabolites by a Co-Culture of Sponge-Associated Actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163 [PDF]

, 2014
Two sponge-derived actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163, were grown in co-culture and the presence of induced metabolites monitored by ¹H NMR.
Abdelmohsen, Usama, Dashti, Yousef, Grkovic, Tanja, Hentschel, Ute, Quinn, Ronald   +4 more
core   +2 more sources

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Structure of New Cyclic Depsipeptides, Bu-2841-08 and -10

The Journal of Antibiotics, 1995
The structures of new antibiotics, Bu-2841-08 and -10, have been determined. They are cyclic depsipeptides and the sequence of amino acid residues was established by mass spectral analysis of the hydrolyzed linear peptide and NMR spectral analysis of the parent cyclic peptides.
T, Fukai, J, Kuroda, M, Konishi, T, Nomura, N, Naruse, R, Isobe   +5 more
openaire   +3 more sources

Linking molecular architecture to antibacterial functions: a chemical biology view of cyclic depsipeptides

Frontiers in Chemistry
Antimicrobial depsipeptides and cyclodepsipeptides represent a structurally diverse class of natural products that have gained renewed attention as both antibacterial agents and molecular tools to interrogate bacterial physiology.
Sachin Baravkar, Varsha J. Thombare, Varsha J. Thombare, Yuezhou Wu, Yuezhou Wu, Nitin A. Patil, Nitin A. Patil   +6 more
doaj   +1 more source

Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Yoshitaka Moriyama, Hikari Sada, Takeshi Nanjo   +2 more
wiley   +1 more source

Chemoenzymatic Synthesis of Cryptophycin Anticancer Agents by an Ester Bond-Forming Non-ribosomal Peptide Synthetase Module [PDF]

, 2011
Cryptophycins (Crp) are a group of cyanobacterial depsipeptides with activity against drug-resistant tumors. Although they have been shown to be promising, further efforts are required to return these highly potent compounds to the clinic through a new ...
Bolduc, Kyle L., Ding, Yousong, Håkansson, Kristina, Rath, Christopher M., Sherman, David H.   +4 more
core   +1 more source

Microbial communities and bioactive compounds in marine sponges of the family Irciniidae-a review [PDF]

, 2014
Marine sponges harbour complex microbial communities of ecological and biotechnological importance. Here, we propose the application of the widespread sponge family Irciniidae as an appropriate model in microbiology and biochemistry research. Half a gram
Anand, Asano, Bandara, Bayer, Bringmann, Brochier-Armanet, Cardoso, Cook, Cook, Cristiane Hardoim, De Caralt, De Rosa, De Rosa, De Rosa, De Rosa, De Voogd, Degrassi, di Camillo, Dieckmann, Dobretsov, Duckworth, Duckworth, Enticknap, Ereskovsky, Erwin, Erwin, Erwin, Esteves, Fan, Fan, Fieseler, Fiore, Fisch, Flemer, Friedrich, Gaino, Han, Hardoim, Hardoim, Hardoim, Hentschel, Hentschel, Hentschel, Hentschel, Hochmuth, Hoffmann, Hoffmann, Holden, Höller, Isaacs, Jaeckle, Kalia, Kalinovskaya, Kamke, Kamke, Lee, Lee, Lee, Li, Lindquist, Liu, Lopanik, Lopanik, Lopanik, Lopanik, Love, Luter, Maldonado, Man-Aharonovich, Mohamed, Mohamed, Mohamed, Mohamed, Mohamed, Muscholl-Silberhorn, Osinga, O’Halloran, Pantile, Paz, Pester, Piel, Piel, Pita, Pita, Pita, Prokof'eva, Rinkevich, Rodrigo Costa, Sara, Schirmer, Schmitt, Schmitt, Schmitt, Sharp, Siegl, Siegl, Simister, Simister, Simister, Skindersoe, Spalding, Spang, Stabili, Staunton, Sudek, Tabares, Taylor, Taylor, Thakur, Thakur, Thiel, Thomas, Thomas, Usher, Usher, Vacelet, Van Soest, Van Treeck, Webster, Webster, Webster, Webster, Webster, Webster, Webster, Webster, Weisz, Wilkinson, Wilkinson, Wilkinson, Wilkinson, Wulff, Wörheide, Yang, Zan, Zehr, Zehr   +136 more
core   +2 more sources

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source