Results 71 to 80 of about 497 (160)

Synthesis of Peptides, Peptide Nucleic Acid Components, and Other Biogenic Compounds From a Three‐Component Prebiotic Mixture

Chemistry – A European Journal, Volume 32, Issue 9, 2 March 2026.
High‐energy proton irradiation of a formamide–diaminomaleonitrile–glycine system in the presence of meteorites produces a broad spectrum of biogenic compounds, including nucleobases, nucleosides, peptides, and nucleobase–peptide conjugates, highlighting a chemically plausible prebiotic network.
Bruno Mattia Bizzarri, Rosangela Santalucia, Eleonora Mancin, Mikhail Kapralov, Eugene Krasavin, Raffaele Saladino, Ernesto Di Mauro   +6 more
wiley   +1 more source

Turnagainolides A and B, Cyclic Depsipeptides Produced in Culture by a Bacillus sp.: Isolation, Structure Elucidation, and Synthesis

, 2016
Two new cyclic depsipeptides, turnagainolides A (1) and B (2), have been isolated from laboratory cultures of a marine isolate of Bacillus sp. The structures of 1 and 2, which are simply epimers at the site of macrolactonization, were elucidated by ...
Raymond J. Andersen (155984), Yonghong Zhang (20918), Dehai Li (1433623), Helen Bottriell (1490728), Alice L.-F. Mui (2196682), Ashraf Amlani (2196679), Gavin Carr (1278387), David E. Williams (155960)   +7 more
core   +1 more source

Plitidepsin Has a Safe Cardiac Profile: A Comprehensive Analysis

Marine Drugs, 2011
Plitidepsin is a cyclic depsipeptide of marine origin in clinical development in cancer patients. Previously, some depsipeptides have been linked to increased cardiac toxicity.
Carmen Kahatt, Cinthya Coronado, Pilar Lardelli, Claudia Silvia Corrado, Elena Roy, Vicente Alfaro, Bernardo Miguel-Lillo, Sonia Extremera, Arturo Soto-Matos, Sergio Szyldergemajn   +9 more
doaj   +1 more source

Design, synthesis, conformational and membrane ion transport studies of proline-adamantane hybrid cyclic depsipeptides

, 2008
The design, synthesis, conformational, crystallographic, and ion transport studies of 30-membered, proline containing depsipeptides that incorporate the rigid low molecular weight lipophilic adamantane (Adm) building blocks are reported.
Ranganathan, Darshan, Nagaraj, Ramakrishnan, Kumar, Mittapalli Gopi, Karle, Isabella L.   +3 more
core   +1 more source

Clavariopsins C–I, Antifungal Cyclic Depsipeptides from the Aquatic Hyphomycete Clavariopsis aquatica [PDF]

, 2019
Seven new cyclic depsipeptides, clavariopsins C–I (3–9), together with two known congeners, clavariopsins A and B (1 and 2), were isolated from the aquatic hyphomycete Clavariopsis aquatica.
Kaida, Kenichi, Soe, Thin Wut, Sawaki, Yuki, Tomura, Tomohiko, Han, Chunguang, Fudou, Ryosuke, Ojika, Makoto   +6 more
core   +1 more source

Cryptophycin unit B analogues

Beilstein Journal of Organic Chemistry
Drug conjugates using toxic payloads are a promising approach for selectively combating cancer while sparing healthy tissue. The lack of highly cytotoxic and at the same time selective therapeutics against cancer is an ongoing challenge.
Thomas Schachtsiek, Jona Voss, Maren Hamsen, Beate Neumann, Hans-Georg Stammler, Norbert Sewald   +5 more
doaj   +1 more source

Total Synthesis of the Marine Cyclic Depsipeptide Lagunamide D

Marine Drugs
Lagunamide D is a structurally distinct 26-membered cytotoxic cyclic depsipeptide, originally isolated from a marine cyanobacterium. It exhibits potent antiproliferative activity in the low nanomolar range against A549 human lung adenocarcinoma cells and HCT116 colon cancer cells.
Huiru Nan, Xiong-En Long, Jianfei He, Hailiang Xing, Min-Jing Cheng, Jin-Bao Peng, Tao Ye, Jia-Lei Yan, Junyang Liu   +8 more
openaire   +3 more sources

Cyanobacterial Peptides in Anticancer Therapy: A Comprehensive Review of Mechanisms, Clinical Advances, and Biotechnological Innovation

Marine Drugs
Cyanobacteria-derived peptides represent a promising class of anticancer agents due to their structural diversity and potent bioactivity. They exert cytotoxic effects through mechanisms including microtubule disruption, histone deacetylase inhibition ...
Heayyean Lee, Khuld Nihan, Yale Ryan Kwon   +2 more
doaj   +1 more source

Rakicidins G - I, cyclic depsipeptides from marine Micromonospora chalcea FIM 02-523

, 2018
Rakicidins G-I (1–3), three new cyclic depsipeptides including a long aliphatic chain without terminal methyl branching were isolated from culture broth of Micromonospora chalcea FIM 02–523, along with rakicidin E (4). Their structures were elucidated by
Zhao, Wei, Zhou, Jian, Chen, Xiao-Ming, Lian, Yun-Yang, Jiang, Hong, Jiang, Hong-Lei, Chen, Li, Lin, Feng   +7 more
core   +1 more source

Adiponectin-Secretion-Promoting Cyclic PeptidePolyketide Hybrids from a Halophyte-Associated Fungus, Colletotrichum gloeosporioides JS0417

, 2022
Three new cyclic peptide–polyketide hybrids (1–3) and two new chaetiacandin-type polyketides (4 and 5) along with nine known compounds were isolated from cultures of a halophyte-associated fungus, Colletotrichum gloeosporioides JS0417.
Jaekyeong Kim, Hyejin Ko (9851430), Minsoo Noh, Junpyo Gong, Stephen T. Deyrup (2309533), Sunghee Bang, Stephen T. Deyrup, Sang Hee Shim (683665), Changyeol Lee, Seungchan An (6256061), Seungchan An, Junpyo Gong (12096766), Hyejin Ko, Minsoo Noh (213445), Changyeol Lee (3512897), Sang Hee Shim, Jaekyeong Kim (11260916), Sunghee Bang (4024820)   +17 more
core   +1 more source