Results 71 to 80 of about 1,254,991 (185)

Cyclic Carbo-Isosteric Depsipeptides and Peptides as a Novel Class of Peptidomimetics

, 2016
A novel and highly efficient cyclization method has been developed to access a new class of cyclic carbo-isosteric depsipeptides and carbo-isosteric peptides.
Hans-Jörg Roth (1508320), Stéphanie M. Guéret (1837621), Peter Meier (1837624)   +2 more
core   +1 more source

UZH: Alma Mater and Birthplace of Polyphor Ltd

CHIMIA, 2008
Daniel and Jean-Pierre Obrecht and Michael Altorfer present a brief account of the role that the Institute of Organic Chemistry, University of Zurich, has played in their scientific and professional development leading ultimately to a successful
Daniel Obrecht, Jean-Pierre Obrecht, Michael Altorfer   +2 more
doaj   +1 more source

Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp

Tetrahedron Letters, 2015
Two new HIV-inhibitory depsipeptides, stellettapeptins A (1) and B (2), were isolated from an extract of the marine sponge Stelletta sp., collected from northwestern Australia. Structures of these cyclic nonribosomal peptides were elucidated on the basis
H. Shin, M. Rashid, L. K. Cartner, Heidi R. Bokesch, Jennifer Wilson, J. Mcmahon, K. Gustafson   +6 more
semanticscholar   +1 more source

Characterization of the Ohmyungsamycin Biosynthetic Pathway and Generation of Derivatives with Improved Antituberculosis Activity

Biomolecules, 2019
The cyclic depsipeptides ohmyungsamycin (OMS) A (1) and B (2), isolated from the marine-derived Streptomyces sp. SNJ042, contain two non-proteinogenic amino acid residues, β-hydroxy-l-phenylalanine (β-hydroxy-l-Phe) and 4-methoxy-l-tryptophan ...
Eunji Kim, Yern-Hyerk Shin, Tae Ho Kim, Woong Sub Byun, Jinsheng Cui, Young Eun Du, Hyung-Ju Lim, Myoung Chong Song, An Sung Kwon, Sang Hyeon Kang, Jongheon Shin, Sang Kook Lee, Jichan Jang, Dong-Chan Oh, Yeo Joon Yoon   +14 more
doaj   +1 more source

Anthraquinones From Epicoccum sp., a Fungus Isolated From Gut of Dione juno That Feeds on Passifloras

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
An Epicoccum fungus was isolated from gut of larvae of the butterfly Dione juno juno that feeds intensively on leaves of Passifloras. This fungus produces hydroxyanthraquinones that moderately inhibits growth of some Bacillus that coexist with the fungus in the insect gut, suggesting that it is probably important for microbial embalance in gut flora ...
Jessica Teixeira Dias, Alef dos Santos, Mauricio Augusto P. M. S. Alves, Clovis Wesley Oliveira de Souza, Eduardo Jorge Pilau, Edson Rodrigues‐Filho   +5 more
wiley   +1 more source

Cryptophycin unit B analogues

Beilstein Journal of Organic Chemistry
Drug conjugates using toxic payloads are a promising approach for selectively combating cancer while sparing healthy tissue. The lack of highly cytotoxic and at the same time selective therapeutics against cancer is an ongoing challenge.
Thomas Schachtsiek, Jona Voss, Maren Hamsen, Beate Neumann, Hans-Georg Stammler, Norbert Sewald   +5 more
doaj   +1 more source

SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.

PLoS ONE, 2016
In order to expand the repertoire of antifungal compounds a novel, high-throughput phenotypic drug screen targeting fungal phosphatidylserine (PS) synthase (Cho1p) was developed based on antagonism of the toxin papuamide A (Pap-A).
Chelsi D Cassilly, Marcus M Maddox, Philip T Cherian, John J Bowling, Mark T Hamann, Richard E Lee, Todd B Reynolds   +6 more
doaj   +1 more source

Cyanobacterial Peptides in Anticancer Therapy: A Comprehensive Review of Mechanisms, Clinical Advances, and Biotechnological Innovation

Marine Drugs
Cyanobacteria-derived peptides represent a promising class of anticancer agents due to their structural diversity and potent bioactivity. They exert cytotoxic effects through mechanisms including microtubule disruption, histone deacetylase inhibition ...
Heayyean Lee, Khuld Nihan, Yale Ryan Kwon   +2 more
doaj   +1 more source

Plitidepsin Has a Safe Cardiac Profile: A Comprehensive Analysis

Marine Drugs, 2011
Plitidepsin is a cyclic depsipeptide of marine origin in clinical development in cancer patients. Previously, some depsipeptides have been linked to increased cardiac toxicity.
Carmen Kahatt, Cinthya Coronado, Pilar Lardelli, Claudia Silvia Corrado, Elena Roy, Vicente Alfaro, Bernardo Miguel-Lillo, Sonia Extremera, Arturo Soto-Matos, Sergio Szyldergemajn   +9 more
doaj   +1 more source

Cyclic cohomology after the excision theorem of Cuntz and Quillen [PDF]

, 2013
The excision theorem of Cuntz and Quillen established the existence of a six term exact sequence in the bivariant periodic cyclic cohomology HP*(–,–) associated with an arbitrary algebra extension 0 ? S ? P ? Q ? 0.
Jacek Brodzki, Brodzki, Jacek
core   +1 more source