Results 101 to 110 of about 1,254,991 (185)
Adsorption of cyclic depsipeptide mycotoxins to glass
, 2014 During analytical processes, adsorption of peptides, which is believed to mostly be due to non-covalent interactions and depending upon the experimental conditions, cannot only lead to significant loss of the analyte, but also to increased analytical variability. This undesirable aspect, however, has been given scant attention [1-2].
Taevernier, Lien +2 more
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ACS Medicinal Chemistry LettersA majority of drugs are small molecules that satisfy Lipinski’s Rule-of-Five (Ro5), but efforts to target topologically complex biomolecular interactions have reignited interest in nonconforming molecular therapeutics, dubbed “beyond Ro5 (bRo5)”. Broadly
Madelaine P. Thorpe +2 more
semanticscholar +1 more source
Aminoacid sequencing in cyclic peptides and depsipetides
, 2001 Natural or synthetic cyclic peptides and depsipeptides involve antibiotics, toxins, immunomodulators, ion transport regulators, and inhibitors of enzymes or protein-protein ...
Havlíček, Vladimír
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Total Synthesis of the Cyclic Depsipeptide Leualacin [PDF]
The Journal of Organic Chemistry, 1995 openaire +2 more sources
Studies on the biosynthesis of cyclic depsipeptides in Serratia marcescens [PDF]
Biochemical Journal, 1972 M A, Bermingham, B S, Deol, J L, Still
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Macrocyclization strategies for the total synthesis of cyclic depsipeptides
Organic & Biomolecular Chemistry, 2023Cyclic depsipeptides, bioactive natural products containing ester(s) and amides in the macrocycle, are synthesized via 3 strategies, macrolactamization in solution, macrolactamization on-resin, and macrolactonization.
André R. Paquette, Christopher N. Boddy
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Journal of the American Society for Mass Spectrometry
A critical challenge in the structural characterization of metal complexes in apolar environments is distinguishing transient structural isomers within an ensemble of lower- and higher-order assemblies.
Thanh Do +2 more
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A critical challenge in the structural characterization of metal complexes in apolar environments is distinguishing transient structural isomers within an ensemble of lower- and higher-order assemblies.
Thanh Do +2 more
exaly +2 more sources
Cyclic depsipeptides as potential cancer therapeutics
Anti-Cancer Drugs, 2015Cyclic depsipeptides are polypeptides in which one or more amino acid is replaced by a hydroxy acid, resulting in the formation of at least one ester bond in the core ring structure. Many natural cyclic depsipeptides possessing intriguing structural and biological properties, including antitumor, antifungal, antiviral, antibacterial, anthelmintic, and ...
Jirouta, Kitagaki +4 more
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