Results 121 to 130 of about 497 (160)
Some of the next articles are maybe not open access.
Cyclic Depsipeptides, Callipeltins
2020Marine sponges are considered as an untapped reservoir of biologically active natural compounds exhibiting numerous interesting and potentially useful pharmacological activities, including antimicrobial, antifungal, cytotoxic, anti-inflammatory, and immunostimulatory activities.
Reda A. Abdelhamid, Hiroyuki Konno
openaire +1 more source
Synergistic action of a cyclic depsipeptide and piperazine on nematodes
Parasitology Research, 2000The present study describes the synergistic effects of the cyclic depsipeptide BAY 44-4400 and piperazine in the treatment against the nematodes Trichinella spiralis, Heligmosomoides polygyrus, and Heterakis spumosa. The in vitro anthelmintic activity of a combination of the two compounds (1.7 motility units) against T.
F, Nicolay +3 more
openaire +2 more sources
Total synthesis of antimicrobial and antitumor cyclic depsipeptides
Chemical Communications, 2010The total synthesis of natural products "has to be viewed as an art and a science that needs to be advanced for its own sake" (K. C. Nicolaou) and indeed, the achievements within this field of chemistry during the last decades are astonishing. However, besides its inherent beauty, total synthesis also opens the gates widely to a better understanding of
Wenhua, Li +2 more
openaire +2 more sources
A Total Synthesis of the Cyclic Depsipeptide Chaiyaphumine‐A
ChemistrySelect, 2017Abstract The first total synthesis of Chaiyaphumine‐A, a cyclic depsipentapeptide isolated from Xenorhabdus SP. PB614 which showed good activity against Plasmodium falcifarum (IC 50 = 0.61 μM ...
Somnath S. Gholap, Sandip R. Ugale
openaire +1 more source
European Journal of Medicinal Chemistry, 2018 G proteins are key mediators in the signaling of G protein-coupled receptors and involved in a plethora of important physiological processes. The natural product cyclic depsipeptides YM-254890 and FR900359 are the only known selective inhibitors of the ...
Guanhua Zhang +2 more
exaly +2 more sources
Chemistry and Biology of Cyclic Depsipeptides of Medicinal and Biological Interest
Current Medicinal Chemistry, 2004Cyclodepsipeptides comprise a wide variety of cyclic peptides of natural origin and are characterized by the occurrence of at least one ester linkage. The great interest that this class of natural products has elicited in scientific community is explained by their wide range of biological activities, intriguing mechanisms of action and attractive ...
Francisco, Sarabia +4 more
openaire +2 more sources
Total synthesis of an antifungal cyclic depsipeptide aureobasidin A
Tetrahedron, 1996Abstract The first total synthesis of antifungal cyclic depsipeptide aureobasidin A is described. The synthesis was achieved mainly using bromotris(pyrrolidino)phosphonium hexafluorophosphate (PyBroP) as a coupling reagent. Peptide cyclization was carried out between L- allo -isoleucine (L- a lle 1 ) and L- Pro 9 residues in the linear nonapeptide ...
Toru Kurome +6 more
openaire +1 more source
ChemInform Abstract: The Cyclic Depsipeptide Backbone of the Didemnins.
ChemInform, 1996AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
S. C. MAYER +2 more
openaire +1 more source
Asymmetric Total Syntheses of Marine Cyclic Depsipeptide Halipeptins A–D
Chemistry – A European Journal, 2006AbstractHalipeptins A–D (1 a–d) are a family of natural cyclic depsipeptides isolated from marine sponges. Total syntheses of these four compounds are detailed in this report. The key elements in this synthesis include the elaboration of the polysubstituted decanoic acid parts by two asymmetric aldol reactions, assembly of the N‐methyl‐δ ...
Shouyun, Yu, Xianhua, Pan, Dawei, Ma
openaire +2 more sources
New Cyclic Depsipeptide from an Endophytic Actinomycete
Chemistry of Natural Compounds, 2015A new sixteen-member cyclic depsipeptide, strepeptolide, was isolated from the culture broth of an endophytic actinomycetes strain. The structure of the compound was elucidated by detailed 1D, 2D NMR, HR-ESI-MS, and IR spectroscopic data.
He Rong +8 more
openaire +1 more source