Results 161 to 170 of about 3,649 (185)

Rakicidin C, A New Cyclic Depsipeptide fromStreptomycessp.

European Journal of Organic Chemistry, 2000
Chemical screening of extracts of Actinomycetes strains has led to the detection, isolation, and structure elucidation of the new cyclic depsipeptide rakicidin C (1). The secondary metabolite from Streptomyces sp. (strain GT 61042) is built-up from glutamine, N-methyl glycine, 4-amino-(2E,4)-pentadienoic acid, and 3-hydroxy-2,4,6,8-tetramethylnonanoic ...
Jin-Feng Hu, Dirk Wunderlich, Isabel Sattler, Xiao-Zhang Feng, Susanne Grabley, Ralf Thiericke   +5 more
openaire   +1 more source

Asymmetric Total Syntheses of Marine Cyclic Depsipeptide Halipeptins A–D

Chemistry – A European Journal, 2006
AbstractHalipeptins A–D (1 a–d) are a family of natural cyclic depsipeptides isolated from marine sponges. Total syntheses of these four compounds are detailed in this report. The key elements in this synthesis include the elaboration of the polysubstituted decanoic acid parts by two asymmetric aldol reactions, assembly of the N‐methyl‐δ ...
Shouyun, Yu, Xianhua, Pan, Dawei, Ma
openaire   +2 more sources

Synergistic action of a cyclic depsipeptide and piperazine on nematodes

Parasitology Research, 2000
The present study describes the synergistic effects of the cyclic depsipeptide BAY 44-4400 and piperazine in the treatment against the nematodes Trichinella spiralis, Heligmosomoides polygyrus, and Heterakis spumosa. The in vitro anthelmintic activity of a combination of the two compounds (1.7 motility units) against T.
F, Nicolay, A, Harder, G, von Samson-Himmelstjerna, H, Mehlhorn   +3 more
openaire   +2 more sources

Antifungal Cyclic Depsipeptide, Eujavanicin A, Isolated from Eupenicillium javanicum

Journal of Natural Products, 2008
In the course of searching for new antifungal agents, a new cyclic depsipeptide, eujavanicin A (1), was isolated from Eupenicillium javanicum as an antifungal agent against the human pathogenic filamentous fungus Aspergillus fumigatus. The structure of 1 was established by spectroscopic and chemical investigations.
Shou, Nakadate, Koohei, Nozawa, Hiroyasu, Sato, Hitoshi, Horie, Yuichi, Fujii, Masahiro, Nagai, Tomoo, Hosoe, Ken-ichi, Kawai, Takashi, Yaguchi   +8 more
openaire   +2 more sources

Diverse Synthesis of Marine Cyclic Depsipeptide Lagunamide A and Its Analogues

The Journal of Organic Chemistry, 2013
The asymmetric total synthesis of lagunamide A (3.0%, 20 steps longest linear sequence) and its five analogues, including the structure dehydrated at the C37 position, are detailed in this report. The key feature in this diverse synthesis includes the elaboration of four consecutive chiral centers at C37-40 and the final macrocyclization. Starting from
Wei, Huang, Rong-Guo, Ren, Han-Qing, Dong, Bang-Guo, Wei, Guo-Qiang, Lin   +4 more
openaire   +2 more sources

Total synthesis of an antifungal cyclic depsipeptide aureobasidin A

Tetrahedron, 1996
Abstract The first total synthesis of antifungal cyclic depsipeptide aureobasidin A is described. The synthesis was achieved mainly using bromotris(pyrrolidino)phosphonium hexafluorophosphate (PyBroP) as a coupling reagent. Peptide cyclization was carried out between L- allo -isoleucine (L- a lle 1 ) and L- Pro 9 residues in the linear nonapeptide ...
Toru Kurome, Kaoru Inami, Tetsuya Inoue, Katsushige Ikai, Kazutoh Takesako, Ikunoshin Kato, Tetsuo Shiba   +6 more
openaire   +1 more source

ChemInform Abstract: The Cyclic Depsipeptide Backbone of the Didemnins.

ChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
S. C. MAYER, P. J. CARROLL, M. M. JOULLIE   +2 more
openaire   +1 more source

Bacterial Production of the Tunicate-Derived Antitumor Cyclic Depsipeptide Didemnin B

Journal of Natural Products, 2011
Natural products obtained from marine invertebrates such as sponges and tunicates are attractive sources of drugs. However, a critical obstacle in the development of these compounds is the problem of supply. In most cases, neither chemical synthesis nor mariculture of invertebrates is economically feasible.
Moriya, Tsukimoto, Masato, Nagaoka, Yoshiyuki, Shishido, Junji, Fujimoto, Fukiko, Nishisaka, Sachiko, Matsumoto, Enjuro, Harunari, Chiaki, Imada, Takeshi, Matsuzaki   +8 more
openaire   +2 more sources

A Total Synthesis of the Cyclic Depsipeptide Chaiyaphumine‐A

ChemistrySelect, 2017
Abstract The first total synthesis of Chaiyaphumine‐A, a cyclic depsipentapeptide isolated from Xenorhabdus SP. PB614 which showed good activity against Plasmodium falcifarum (IC 50 = 0.61 μM ...
Somnath S. Gholap, Sandip R. Ugale
openaire   +1 more source

ChemInform Abstract: Total Synthesis of the Cyclic Depsipeptide Leualacin.

ChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire   +1 more source