Results 91 to 100 of about 485,549 (166)

A STING-based fluorescent polarization assay for monitoring activities of cyclic dinucleotide metabolizing enzymes. [PDF]

RSC Chem Biol, 2021
Karanja CW, Yeboah KS, Ong WWS, Sintim HO.   +3 more
europepmc   +1 more source

Structural basis for synthase activation and cellulose modification in the E. coli Type II Bcs secretion system

Nature Communications
Bacterial cellulosic polymers constitute a prevalent class of biofilm matrix exopolysaccharides that are synthesized by several types of bacterial cellulose secretion (Bcs) systems, which include conserved cyclic diguanylate (c-di-GMP)-dependent ...
Itxaso Anso, Samira Zouhir, Thibault Géry Sana, Petya Violinova Krasteva   +3 more
doaj   +1 more source

Nanoparticle delivery improves the pharmacokinetic properties of cyclic dinucleotide STING agonists to open a therapeutic window for intravenous administration. [PDF]

J Control Release, 2021
Wehbe M, Wang-Bishop L, Becker KW, Shae D, Baljon JJ, He X, Christov P, Boyd KL, Balko JM, Wilson JT.   +9 more
europepmc   +1 more source

Structural and biochemical insights into the inhibition of <i>Mycobacterium tuberculosis</i> cyclic dinucleotide phosphodiesterase by a sulfur-modified cyclic dinucleotide analog. [PDF]

RSC Chem Biol
Hanuman DS, Neeharika S, Murari SK, Yeboah SK, Sintim HO, Rajakumara E.   +5 more
europepmc   +1 more source

STING agonist profiling by nucleotide library defines structural determinants of cyclic dinucleotide recognition. [PDF]

iScience
Bekere I, Hubarzhevska Y, Egender SV, Quoika PK, Öllinger R, Schrimpf MR, Rad R, Zacharias M, de Oliveira Mann CC.   +8 more
europepmc   +1 more source

A multidomain peptide hydrogel-liposome composite for controlled release of a cyclic dinucleotide in oral cancer. [PDF]

J Control Release
Swain JWR, Molina AH, Sunga GM, Chew-Martinez D, Dharmaraj N, Perez AC, Dey A, Vázquez-Rosado EJ, Young S, Hartgerink JD.   +9 more
europepmc   +1 more source

Titrating Polyarginine into Nanofibers Enhances Cyclic-Dinucleotide Adjuvanticity in Vitro and after Sublingual Immunization. [PDF]

ACS Biomater Sci Eng, 2021
Kelly SH, Cossette BJ, Varadhan AK, Wu Y, Collier JH.   +4 more
europepmc   +1 more source

1228 Enhancing STING activation by cyclic dinucleotide-manganese particles for systemic cancer immunotherapy

Journal for ImmunoTherapy of Cancer, 2023
Xingwu Zhou, Wang Gong, James J Moon, Xiaoqi Sun, Ziye Wan, Yu Leo Lei   +5 more
doaj   +1 more source

Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500. [PDF]

Bioconjug Chem
Lee HM, Abdul-Hadi K, Appleman VA, Cardin D, Dong L, England D, Ganno ML, Gershman R, Gigstad K, Gulavita N, Hu Z, Huang J, Huang SC, Lok D, Ma L, Malley J, Mizutani M, Molchanova N, Piatkov KI, Rice E, Shi Z, Vyskocil S, Wang J, Xu H, Xu T, Zhang DM, Zhang J, Abu-Yousif AO.   +27 more
europepmc   +1 more source

Biofilm formation by <i>Staphylococcus aureus</i> is triggered by a drop in the levels of a cyclic dinucleotide. [PDF]

Proc Natl Acad Sci U S A
Syed AK, Baral R, Van Vlack ER, Gil-Marqués ML, Lenhart T, Hooper DC, Kahne D, Losick R, Bradshaw N.   +8 more
europepmc   +1 more source