Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis? [PDF]
Pathogens, 2021 Host cells can recognize cytosolic double-stranded DNAs and endogenous second messengers as cyclic dinucleotides—including c-di-GMP, c-di-AMP, and cGAMP—of invading microbes via the critical and essential innate immune signaling adaptor molecule known as
Mervi Gursoy +2 more
exaly +4 more sources
Novel Modifications and Delivery Modes of Cyclic Dinucleotides for STING Activation in Cancer Treatment [PDF]
International Journal of NanomedicineYanjun Lu,1,* Zhiyan Li,2,* Xudong Zhu,1 Qingwei Zeng,1 Song Liu,1 Wenxian Guan1 1Division of Gastric Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing ...
Zhiyan Li
exaly +4 more sources
Highly Efficient Preparation of Cyclic Dinucleotides via Engineering of Dinucleotide Cyclases in Escherichia coli [PDF]
Frontiers in Microbiology, 2019 Cyclic dinucleotides (CDNs) are widely used secondary signaling molecules in bacterial and mammalian cells. The family of CDNs includes c-di-GMP, c-di-AMP and two distinct versions of hybrid cGAMPs.
Deyu Zhu, Huanmin Niu, Yaoyao Li
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Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio [PDF]
Frontiers in Microbiology, 2022 The cyclic GMP-AMP (cGAMP) synthase (cGAS) recognizes cytosolic DNA and synthesizes the second messenger, cGAMP, thus activating the adaptor protein stimulator of interferon genes (STING) and initiating the innate immune responses against microbial ...
Zengzeng Lu +4 more
doaj +2 more sources
Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide [PDF]
Pathogens, 2020 Human gingival fibroblasts (HGFs) recognize microbe-associated molecular patterns (MAMPs) and respond with inflammatory proteins. Simultaneous impacts of bacterial cyclic di-guanosine monophosphate (c-di-GMP), cyclic di-adenosine monophosphate (c-di-AMP),
Samira Elmanfi +5 more
doaj +2 more sources
The World of Cyclic Dinucleotides in Bacterial Behavior [PDF]
Molecules, 2020 The regulation of multiple bacterial phenotypes was found to depend on different cyclic dinucleotides (CDNs) that constitute intracellular signaling second messenger systems.
Aline Dias da Purificação +4 more
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Convergent evolution of viral nucleases targeting cyclic dinucleotides [PDF]
PLoS PathogensPoxviruses, African swine fever virus (ASFV), and bacteriophages have independently evolved nucleases that degrade cyclic dinucleotides (CDNs), which are critical second messengers that mediate antiviral responses.
Zichen Li, Leiliang Zhang
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Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP [PDF]
Journal of Oral Microbiology, 2022 Background Constant exposure of human gingival fibroblasts (HGFs) to oral pathogens trigger selective immune responses. Recently, the activation of immune response to cyclic dinucleotides (CDNs) via STING has come to the forefront.
Kenneth I. Onyedibe +5 more
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The Promise and Challenges of Cyclic Dinucleotides as Molecular Adjuvants for Vaccine Development [PDF]
Vaccines, 2021 Cyclic dinucleotides (CDNs), originally discovered as bacterial second messengers, play critical roles in bacterial signal transduction, cellular processes, biofilm formation, and virulence. The finding that CDNs can trigger the innate immune response in
Hongbin Yan, Wangxue Chen
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Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 Oral cavity acts as a reservoir of bacterial pathogens for systemic infections and several oral microorganisms have been linked to systemic diseases.
Ulvi K. Gürsoy +4 more
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