cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity [PDF]
EMBO Reports, 2019 Gang Pei +2 more
exaly +2 more sources
Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State [PDF]
Immunity, 2017 Adelle McFarland +2 more
exaly +2 more sources
SLC19A1 transports immunoreactive cyclic dinucleotides. [PDF]
Nature, 2019 The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway3.
Luteijn RD +10 more
europepmc +6 more sources
Versatile modes of cellular regulation via cyclic dinucleotides. [PDF]
Nat Chem Biol, 2017 International audienceSince the discovery of c-di-GMP almost three decades ago, cyclic dinucleotides (CDNs) have emerged as widely used signaling molecules in most kingdoms of life.
Krasteva PV, Sondermann H.
europepmc +2 more sources
5′-Phosphorothioester Linked Cyclic Dinucleotides, Endo-S-CDNs, Displaying Impressive Antitumor Activities In Vivo when Dosed Subcutaneously [PDF]
ACS Bio & Med Chem AuSimpa K. Yeboah +5 more
doaj +2 more sources
The Characterization of Escherichia coli CpdB as a Recombinant Protein Reveals that, besides Having the Expected 3´-Nucleotidase and 2´,3´-Cyclic Mononucleotide Phosphodiesterase Activities, It Is Also Active as Cyclic Dinucleotide Phosphodiesterase. [PDF]
PLoS ONE, 2016 Endogenous cyclic diadenylate phosphodiesterase activity was accidentally detected in lysates of Escherichia coli BL21. Since this kind of activity is uncommon in Gram-negative bacteria, its identification was undertaken.
Iralis López-Villamizar +6 more
doaj +1 more source
Au naturale: use of biologically derived cyclic di-nucleotides for cancer immunotherapy
Open Biology, 2021 Cyclic di-nucleotides (CDNs) are widespread second messenger signalling molecules that regulate fundamental biological processes across the tree of life.
Christopher M. Waters
doaj +1 more source
Solution Structures of a G‑Quadruplex Bound to Linear- and Cyclic-Dinucleotides
, 2019 Cyclic dinucleotides have emerged as important secondary messengers and cell signaling molecules that regulate several cell responses. A guanine-deficit G-quadruplex structure formation by a sequence containing (4n – 1) guanines, n denoting the number of
Fernaldo Richtia Winnerdy (7573265) +3 more
core +2 more sources
The overlapping host responses to bacterial cyclic dinucleotides [PDF]
Microbes and Infection, 2012 Howard Shuman +2 more
exaly +2 more sources
Cell Reports, 2018 Summary: There are a limited number of adjuvants that elicit effective cell-based immunity required for protection against intracellular bacterial pathogens.
Erik Van Dis +17 more
doaj +1 more source