The Age of Cyclic Dinucleotide Vaccine Adjuvants
Vaccines, 2020 As prophylactic vaccine adjuvants for infectious diseases, cyclic dinucleotides (CDNs) induce safe, potent, long-lasting humoral and cellular memory responses in the systemic and mucosal compartments.
Himanshu Gogoi, Samira Mansouri, Lei Jin
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Polymorphism of Cyclic Dinucleotides
, 2015 Cyclic dinucleotides such as cyclic dimeric guanosine monophosphate (c-di-GMP,) cyclic dimeric adenosine monophosphate (c-di-AMP) and cyclic guanosine-adenosine monophosphate (cGAMP) are found in both prokaryotes and eukaryotes and are important in cell ...
Roembke, Benjamin Thompson
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Biotechnological production of cyclic dinucleotides - challenges and opportunities [PDF]
Biotechnology and Bioengineering, 2021 Cyclic dinucleotides (CDNs) are widely used secondary signaling molecules in prokaryotic and eukaryotic cells. As strong agonists of the stimulator of interferon genes, they are of great interest for pharmaceutical applications. In particular, cyclic-GMP-
Rolf, Jascha +4 more
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Activation of cellular responses by cyclic dinucleotides and Porphyromonas gingivalis lipopolysaccharide: a proteomic study on gingival fibroblasts [PDF]
Journal of Oral MicrobiologyBackground Bacterial cyclic dinucleotides (CDNs), cyclic di-guanosine monophosphate (c-di-GMP), and cyclic di-adenosine monophosphate (c-di-AMP) upregulate interferon signaling proteins of human gingival fibroblasts (HGFs).
Samira Elmanfi +5 more
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Cyclic Dinucleotides Get Stung
Science Signaling, 2011 The adaptor protein STING, which mediates the interferon response to microbial DNA, also acts as a direct sensor of cyclic dinucleotides.
John F. Foley
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Biocatalytic Synthesis of Antiviral Nucleosides, Cyclic Dinucleotides, and Oligonucleotide Therapies [PDF]
Jacs Au, 2023 Sarah Lovelock
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Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein [PDF]
Angewandte Chemie - International Edition, 2021 Thomas Evangelidis +2 more
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Tuning the Innate Immune Response to Cyclic Dinucleotides by Using Atomic Mutagenesis [PDF]
ChemBioChem, 2020 Yichi Su +2 more
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Cyclic dinucleotides at the forefront of innate immunity. [PDF]
Curr Opin Cell Biol, 2020 Cyclic dinucleotides (CDNs) have emerged as ubiquitous signaling molecules in all domains of life. In eukaryotes, CDN signaling systems are evolutionarily ancient and have developed to sense and respond to pathogen infection. On the other hand, dysregulation of these pathways has been implicated in the pathogenesis of autoimmune diseases.
Zaver SA, Woodward JJ.
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Mass spectrometric characterization of cyclic dinucleotides (CDNs) in vivo. [PDF]
Anal Bioanal Chem, 2021 Cyclic dinucleotides (CDNs) are key secondary messenger molecules produced by cyclic dinucleotide synthases that trigger various cellular signaling cascades from bacteria to vertebrates.
Annibal A +5 more
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