Results 41 to 50 of about 439,193 (238)

A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells

Nature Communications, 2020
Cyclic dinucleotides are conserved second messengers but current detection methods are limited. Here the authors engineer a Förster resonance energy transfer (FRET) based biosensor, BioSTING, which gives real-time in vitro detection of these nucleotides.
Alex J. Pollock, Shivam A. Zaver, Joshua J. Woodward   +2 more
doaj   +1 more source

Impact of STING Inflammatory Signaling during Intracellular Bacterial Infections

Cells, 2021
The early detection of bacterial pathogens through immune sensors is an essential step in innate immunity. STING (Stimulator of Interferon Genes) has emerged as a key mediator of inflammation in the setting of infection by connecting pathogen cytosolic ...
Erika S. Guimarães, Fabio V. Marinho, Nina M. G. P. de Queiroz, Maísa M. Antunes, Sergio C. Oliveira   +4 more
doaj   +1 more source

Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness [PDF]

, 2014
cAMP mediates autonomic regulation of heart rate by means of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which underlie the pacemaker current If.
M. Lolicato, Schwede, Frank, Simmons, Katie, S. Zucca, Bucchi, A, Marco Aquila, Fishwick Colin W. G., Simmons, K, Anna Moroni, Johnson, A. Peter, Nardini, M, Colin W G Fishwick, Johnson A. Peter, Annalisa Bucchi, Simmons Katie, A. Bucchi, Lolicato, M, Bolognesi Martino, Kashin, D, G. Thiel, Lolicato Marco, A Peter Johnson, Aquila, Marco, Stefano Zucca, Aquila, M, Dmitry Kashin, Bolognesi, Martino, Zucca, S, Arrigoni, Cristina, Bucchi Annalisa, Lolicato, Marco, Moroni, Anna, DiFrancesco Dario, Martino Bolognesi, Fishwick, CW, A. P. Johnson, A. Moroni, K. Simmons, Dario DiFrancesco, M. Bolognesi, Schroeder Indra, Bucchi, Annalisa, F. Schwede, Nardini Marco, Thiel Gerhard and Moroni Anna, Katie Simmons, Thiel, Gerhard, M. Nardini, Schroeder, I, Thiel, G, D. Difrancesco, Johnson, AP, Indra Schroeder, Kashin Dmitry, Gerhard Thiel, Aquila Marco, Marco Lolicato, D. Kashin, Cristina Arrigoni, Arrigoni Cristina, Bolognesi, M, Zucca, Stefano, Arrigoni, C, C. W. G. Fishwick, Marco Nardini, Schwede, F, Zucca Stefano, Fishwick, Colin W. G., I. Schroeder, DiFrancesco, D, Schroeder, Indra, Kashin, Dmitry, C. Arrigoni, DiFrancesco, Dario, Frank Schwede, Nardini, Marco, Moroni, A, M. Aquila, Schwede Frank, Zucca, S.   +79 more
core   +1 more source

Structural Basis for Molecular Discrimination by a 3′,3′-cGAMP Sensing Riboswitch

Cell Reports, 2015
Cyclic dinucleotides are second messengers that target the adaptor STING and stimulate the innate immune response in mammals. Besides protein receptors, there are bacterial riboswitches that selectively recognize cyclic dinucleotides.
Aiming Ren, Xin C. Wang, Colleen A. Kellenberger, Kanagalaghatta R. Rajashankar, Roger A. Jones, Ming C. Hammond, Dinshaw J. Patel   +6 more
doaj   +1 more source

Novel nanoadjuvants balance immune activation with modest inflammation: implications for older adult vaccines

Immunity & Ageing, 2023
Background Age-associated impairments of immune response and inflammaging likely contribute to poor vaccine efficacy. An appropriate balance between activation of immune memory and inflammatory response may be more effective in vaccines for older adults;
Kathleen A. Ross, April M. Tingle, Sujata Senapati, Kaitlyn G. Holden, Michael J. Wannemuehler, Surya K. Mallapragada, Balaji Narasimhan, Marian L. Kohut   +7 more
doaj   +1 more source

Design, Synthesis and Biological Evaluation of (2′,5′ and 3′5′-Linked) cGAMP Analogs that Activate Stimulator of Interferon Genes (STING)

Molecules, 2020
Stimulator of interferon genes (STING) is an endoplasmic reticulum adaptor transmembrane protein that plays a pivotal role in innate immune system. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in ...
Xin Xie, Junyi Liu, Xiaowei Wang
doaj   +1 more source

Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases

Nature Communications, 2023
Purine-containing nucleotide second messengers regulate diverse cellular activities. Cyclic di-pyrimidines mediate anti-phage functions in bacteria; however, the synthesis mechanism remains elusive.
Chia-Shin Yang, Tzu-Ping Ko, Chao-Jung Chen, Mei-Hui Hou, Yu-Chuan Wang, Yeh Chen   +5 more
doaj   +1 more source

The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy

Molecular Therapy: Nucleic Acids, 2022
Cyclic (di)nucleotides act as universal second messengers endogenously produced by several pathogens. Specifically, the roles of c-di-AMP in Mycobacterium tuberculosis immunity and virulence have been largely explored, although its contribution to the ...
Irene Pérez, Elena Campos-Pardos, Caridad Díaz, Santiago Uranga, Fadel Sayes, Francisca Vicente, Nacho Aguiló, Roland Brosch, Carlos Martín, Jesús Gonzalo-Asensio   +9 more
doaj   +1 more source

Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING

Nature Communications, 2023
The cyclic GMP-AMP synthase (cGAS)/stimulator of interferon gene (STING) signaling pathway plays a critical protective role against viral infections. Metazoan STING undergoes multilayers of regulation to ensure specific signal transduction.
Mei-Hui Hou, Yu-Chuan Wang, Chia-Shin Yang, Kuei-Fen Liao, Je-Wei Chang, Orion Shih, Yi-Qi Yeh, Manoj Kumar Sriramoju, Tzu-Wen Weng, U-Ser Jeng, Shang-Te Danny Hsu, Yeh Chen   +11 more
doaj   +1 more source

Liposomal Delivery of MIW815 (ADU-S100) for Potentiated STING Activation

Pharmaceutics, 2023
Stimulator of interferon genes (STING) agonists can improve the anticancer efficacy of immune checkpoint blockade by amplifying tumor immunogenicity. However, the clinical translation of cyclic dinucleotides (CDNs) as STING agonists is hindered by their ...
Nan Ji, Minjia Wang, Chalet Tan
doaj   +1 more source