Results 51 to 60 of about 439,193 (238)

Enzyme Characterization of Pro-virulent SntA, a Cell Wall-Anchored Protein of Streptococcus suis, With Phosphodiesterase Activity on cyclic-di-AMP at a Level Suited to Limit the Innate Immune System

Frontiers in Microbiology, 2022
Streptococcus suis and Streptococcus agalactiae evade the innate immune system of the infected host by mechanisms mediated by cell wall-anchored proteins: SntA and CdnP, respectively.
Alicia Cabezas, María Jesús Costas, José Canales, Rosa María Pinto, Joaquim Rui Rodrigues, João Meireles Ribeiro, José Carlos Cameselle   +6 more
doaj   +1 more source

Enzymatic synthesis of cyclic dinucleotide analogs by a promiscuous cyclic-AMP-GMP synthetase and analysis of cyclic dinucleotide responsive riboswitches [PDF]

Nucleic Acids Research, 2018
Cyclic dinucleotides are second messenger molecules produced by both prokaryotes and eukaryotes in response to external stimuli. In bacteria, these molecules bind to RNA riboswitches and several protein receptors ultimately leading to phenotypic changes such as biofilm formation, ion transport and secretion of virulence factors.
Katherine D Launer-Felty, Scott A Strobel   +1 more
openaire   +2 more sources

Exploration of the Binding Mechanism of Cyclic Dinucleotide Analogs to Stimulating Factor Proteins and the Implications for Subsequent Analog Drug Design

Biomolecules
Cyclic dinucleotides (CDNs) are cyclic molecules consisting of two nucleoside monophosphates linked by two phosphodiester bonds, which act as a second messenger and bind to the interferon gene stimulating factor (STING) to activate the downstream ...
Shu-Wei Yuan, Hong-Ling Shi, Mu-Ran Fu, Xi-Chuan Zhang, Xiao-Qi Xi, Yao Wang, Tai-Song Shen, Jin-Liang Ma, Cun-Duo Tang   +8 more
doaj   +1 more source

Inhibitors of Cyclic Dinucleotide Phosphodiesterases and Cyclic Oligonucleotide Ring Nucleases as Potential Drugs for Various Diseases

Cells
The phosphodiester linkage is found in DNA, RNA and many signaling molecules, such as cyclic mononucleotide, cyclic dinucleotides (CDNs) and cyclic oligonucleotides (cONs). Enzymes that cleave the phosphodiester linkage (nucleases and phosphodiesterases)
Christopher S. Vennard, Samson Marvellous Oladeji, Herman O. Sintim   +2 more
doaj   +1 more source

Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides [PDF]

, 2014
We describe a simple method for the direct modification of nucleobases in cyclic purine dinucleotides, important signalling molecules in both prokaryotes and eukaryotes. The method tolerates all members of the cyclic dinucleotide family and could be used
Gillingham, Dennis, Laventie, Benoît-Joseph, Zimmermann, Kaspar, Fei, Na, Bizzini, Lorenzo D., Blümli, Seraina, Jenal, Urs, Häussinger, Daniel   +7 more
core   +1 more source

Evaluation of Mucosal and Systemic Vaccine Responses by Cyclic di-GMP (CDG)-adjuvanted Protein Subunit Vaccines

Bio-Protocol, 2019
Intranasal administration of vaccine adjuvants directly deliver therapeutic agents to the lungs to induce potent lung mucosal immune responses. Cyclic di-GMP (CDG) is a promising mucosal vaccine adjuvant candidate capable of inducing protective immunity.
Samira Mansouri, Lei Jin
doaj   +1 more source

The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity

iScience, 2022
Summary: ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that operates by producing metabolite itaconate. Here, we report a key role of STING1 (also known as STING and TMEM173) in mediating ACOD1 expression in myeloid cells in ...
Feng Chen, Runliu Wu, Jiao Liu, Rui Kang, Jinbao Li, Daolin Tang   +5 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The STING in Non-Alcoholic Fatty Liver Diseases: Potential Therapeutic Targets in Inflammation-Carcinogenesis Pathway

Pharmaceuticals, 2022
Non-alcoholic fatty liver disease (NAFLD), an important chronic disease, is one of the major causes of high mortality and creates a substantial financial burden worldwide.
Juan Lv, Chunlei Xing, Yuhong Chen, Huihui Bian, Nanning Lv, Zhibin Wang, Mingming Liu, Li Su   +7 more
doaj   +1 more source