Results 11 to 20 of about 439,193 (238)

Cyclic Dinucleotides and the Innate Immune Response [PDF]

Cell, 2013
Cyclic dinucleotides (CDNs) have been previously recognized as important secondary signaling molecules in bacteria and, more recently, in mammalian cells.
John Mekalanos, Olga Danilchanka
exaly   +7 more sources

Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides [PDF]

Journal of Oral Microbiology, 2019
Background: Cyclic dinucleotides (cyclic di-guanosine monophosphate (c-di-GMP) and cyclic di-adenosine monophosphate (c-di-AMP)) and lipopolysaccharides (LPS) are pathogen-associated molecular patterns (PAMPs).
Samira Elmanfi, Jie Zhou, Herman O. Sintim, Eija Könönen, Mervi Gürsoy, Ulvi Kahraman Gürsoy   +5 more
doaj   +4 more sources

Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides. [PDF]

PLoS ONE, 2013
The STING (stimulator of interferon genes) protein can bind cyclic dinucleotides to activate the production of type I interferons and inflammatory cytokines.
Guanghui Yi, Volker P Brendel, Chang Shu, Pingwei Li, Satheesh Palanathan, C Cheng Kao   +5 more
doaj   +4 more sources

Stimulator of Interferon Genes in Classical Dendritic Cells Controls Mucosal Th17 Responses to Cyclic Dinucleotides for Host Defenses Against Microbial Infections in Gut

Frontiers in Immunology, 2018
Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, stimulator of interferon genes (STING) encoded by Tmem173.
Song Liu, Song Liu, Qiuyuan Xia, Qiuyuan Xia, Xiuwen Wu, Xiuwen Wu, Feng Sun, Feng Sun, Qiongyuan Hu, Qiongyuan Hu, Jie Wu, Jie Wu, Meng Wang, Meng Wang, Qiu Rao, Qiu Rao, Wenxian Guan, Wenxian Guan   +17 more
doaj   +3 more sources

Design, synthesis and bioactivity of cyclic dinucleotides against Lepidoptera insects

Advanced Agrochem
Cyclic dinucleotides (CDNs) play important physiological roles in bacteria, mammals and insects as a novel class of signaling molecules. However, the application of CDNs in agricultural pest control has not been reported yet.
Zhiqiang Xie, Sijing An, Dejun Ma, Zhen Xi   +3 more
exaly   +4 more sources

Catalytic Promiscuity of cGAS: A Facile Enzymatic Synthesis of 2′‐3′‐Linked Cyclic Dinucleotides [PDF]

ChemBioChem, 2020
Enzymatic shortcut: Cyclic dinucleotides, which are of great interest to study immunology and immune oncology, can be synthesized in a one-step biotransformation significantly shortening the chemical synthesis route.
Stephan Lutz, Katrin Rosenthal, Jascha Rolf   +2 more
exaly   +4 more sources

RECONsidering sensing of cyclic dinucleotides [PDF]

Immunity, 2017
Detection of cyclic dinucleotides (cdNs) by the STING pathway potently triggers the antiviral response. McFarland et al. now show that the mouse oxidoreductase RECON acts as a sensor for some bacterial cdNs, modulating innate signaling in a manner ...
Jonathan Maelfait, Maelfait, Jonathan, Jan Rehwinkel, Rehwinkel, J, Maelfait, J, Rehwinkel, Jan   +5 more
core   +5 more sources

Enzymatic Syntheses and Applications of Fluorescent Cyclic Dinucleotides [PDF]

Chemistry - A European Journal, 2020
Bacterial cyclic dinucleotides (CDNs) play important roles in regulating biofilm formation, motility and virulence. In eukaryotic cells, theses bacterial CDNs are recognized as pathogen-associated molecular patterns (PAMPs) and trigger an innate immune ...
Andrea Fin, Alexander R Rovira, Yitzhak Tor   +2 more
exaly   +4 more sources

A carrier for cyclic dinucleotides

Nature Immunology, 2019
Cyclic dinucleotides (CDNs) are potent activators of the innate immune sensor STING.
Ablasser, Andrea, Guey, Baptiste
core   +4 more sources

Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance. [PDF]

PLoS ONE, 2017
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels control cardiac and neuronal rhythmicity. HCN channels contain cyclic nucleotide-binding domain (CNBD) in their C-terminal region linked to the pore-forming transmembrane segment with
Sebastien Hayoz, Purushottam B Tiwari, Grzegorz Piszczek, Aykut Üren, Tinatin I Brelidze   +4 more
doaj   +2 more sources