Results 81 to 90 of about 485,549 (166)

Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations

Microbiology Spectrum
Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the most lethal infectious diseases both historically and in the post-coronavirus disease 2019 era.
Xiaoxia Gu, Chaohu Xiong, Xinyu Wang, Hucheng Zhu, Weiguang Sun, Yan He, Jinwen Zhang   +6 more
doaj   +1 more source

Unraveling the Binding Mode of Cyclic Adenosine–Inosine Monophosphate (cAIMP) to STING through Molecular Dynamics Simulations

Molecules
The stimulator of interferon genes (STING) plays a significant role in immune defense and protection against tumor proliferation. Many cyclic dinucleotide (CDN) analogues have been reported to regulate its activity, but the dynamic process involved when ...
Meiting Wang, Baoyi Fan, Wenfeng Lu, Ulf Ryde, Yuxiao Chang, Di Han, Jiarui Lu, Taigang Liu, Qinghe Gao, Changpo Chen, Yongtao Xu   +10 more
doaj   +1 more source

NrnA Is a Linear Dinucleotide Phosphodiesterase with Limited Function in Cyclic Dinucleotide Metabolism in Listeria monocytogenes. [PDF]

J Bacteriol, 2022
Gall AR, Hsueh BY, Siletti C, Waters CM, Huynh TN.   +4 more
europepmc   +1 more source

Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy. [PDF]

Nat Nanotechnol, 2021
Sun X, Zhang Y, Li J, Park KS, Han K, Zhou X, Xu Y, Nam J, Xu J, Shi X, Wei L, Lei YL, Moon JJ.   +12 more
europepmc   +1 more source

Determination of ADP-Ribosyl Cyclase Activity, Cyclic ADP-Ribose, and Nicotinic Acid Adenine Dinucleotide Phosphate in Tissue Extracts

, 2013
Cyclic ADP-ribose (cADPR) is a novel second messenger that releases calcium from intracellular stores. Although first shown to release calcium in the sea urchin egg, cADPR has been shown since to be active in a variety of cells and tissues, from plant to
Richard M. Graeff, Graeff, RM, Hon Cheung Lee, Lee, HC   +3 more
core   +1 more source

Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists. [PDF]

J Med Chem, 2022
Vavřina Z, Perlíková P, Milisavljević N, Chevrier F, Smola M, Smith J, Dejmek M, Havlíček V, Buděšínský M, Liboska R, Vaneková L, Brynda J, Boura E, Řezáčová P, Hocek M, Birkuš G.   +15 more
europepmc   +1 more source

The cyclic dinucleotide 2'3'-cGAMP induces a broad antibacterial and antiviral response in the sea anemone <i>Nematostella vectensis</i>. [PDF]

Proc Natl Acad Sci U S A, 2021
Margolis SR, Dietzen PA, Hayes BM, Wilson SC, Remick BC, Chou S, Vance RE.   +6 more
europepmc   +1 more source

The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling. [PDF]

Nat Immunol, 2022
Concepcion AR, Wagner LE, Zhu J, Tao AY, Yang J, Khodadadi-Jamayran A, Wang YH, Liu M, Rose RE, Jones DR, Coetzee WA, Yule DI, Feske S.   +12 more
europepmc   +1 more source

Polyamine sequestration of 2′3′-cGAMP constrains intercellular transmission and STING engagement to subvert antitumor immunity

The Journal of Clinical Investigation
The cyclic dinucleotide 2′3′–cyclic guanosine monophosphate–adenosine monophosphate (2′3′-cGAMP) serves as a central immunotransmitter that propagates stimulator of interferon gene–dependent (STING-dependent) innate immunity across tissues; however, how ...
Yunjin Ma, Chunyuan Zhao, Jiacheng Guo, Yue Fu, Wei Wang, Jiangong Zhang, Kun Zhao, Xiangbo Meng, Zhongshang Yuan, Chengjiang Gao, Mutian Jia, Ying Qin, Hui Song, Wei Zhao   +13 more
doaj   +1 more source

Amphiphilic Polyelectrolyte Graft Copolymers Enhance the Activity of Cyclic Dinucleotide STING Agonists. [PDF]

Adv Healthc Mater, 2021
Nguyen DC, Shae D, Pagendarm HM, Becker KW, Wehbe M, Kilchrist KV, Pastora LE, Palmer CR, Seber P, Christov PP, Duvall CL, Wilson JT.   +11 more
europepmc   +1 more source