mBio, 2019 Cyclic dinucleotides (cDNs) act as intracellular second messengers, modulating bacterial physiology to regulate the fundamental life style transition between motility and sessility commonly known as biofilm formation.
Fengyang Li +6 more
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The role of cyclic nucleotide on fetal and neonantal erythropoiesis [PDF]
, 1974 For the purpose to reveal the changes in stimulatory effect of dibutyryl-cyclic- AMP on erythropoiesis during ontogenetic development, the author studied syntheses of DNA, RNA and protein of erythroid cells in fetal liver, neonatal and adult bone marrows
Tada, Hiroshi
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Inhibition of CD38/Cyclic ADP-ribose Pathway Protects Rats against Ropivacaine-induced Convulsion
Chinese Medical Journal, 2017 Background: The CD38/cyclic ADP-ribose (cADPR) pathway plays a role in various central nervous system diseases and in morphine tolerance, but its role in local anesthetic intoxication is unknown.
Yu Zou +3 more
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Screening for Diguanylate Cyclase (DGC) Inhibitors Mitigating Bacterial Biofilm Formation
Frontiers in Chemistry, 2020 The majority of bacteria in the natural environment organize themselves into communal biofilms. Biofilm formation benefits bacteria conferring resistance to harmful molecules (e.g., antibiotics, disinfectants, and host immune factors) and coordinating ...
Kyu Hong Cho +2 more
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Advanced ScienceActivation of the STING pathway represents a potent strategy for cancer immunotherapy. However, the instability and systemic toxicity of STING agonists, especially cyclic dinucleotides (CDNs), limit their use via local administration with poor efficacy ...
Wenjing Zhou +10 more
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Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies
Cancer Biology & MedicineThe intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer treatment. Within this landscape, the innate immune system, a critical sentinel protecting against tumor incursion, is ...
Jiawen Zhang +4 more
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Characterisation of the flavin adenine dinucleotide binding region in Myxococcus xanthus protoporphyrinogen oxidase [PDF]
, 2011 This dissertation focuses on protoporphyrinogen oxidase (PPOX), the penultimate enzyme in the haem biosynthetic pathway. Partial defects in PPOX result in variegate porphyria, an autosomal dominant disorder.
Boateng, Mavis O
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Development of RNA Sensors for Cyclic Dinucleotide Second Messengers in Bacteria [PDF]
, 2014 Second messengers are intracellular signaling molecules that enable cells to respond to environmental changes by relaying signals received at the cell surface to enact downstream physiological effects.
Kellenberger, Colleen Ann
core
Characterization of the Novel Photosynthetic Protein PPP7 involved in Cyclic Electron Flow around PSI [PDF]
, 2007 Photosynthetic organisms are able to convert light energy into chemical energy by the operation of the two photosystems, the cytochrome b6/f complex and the ATPase.
Dal Corso, Giovanni
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Linear matching method on the evaluation of cyclic behaviour with creep effect [PDF]
, 2012 This paper describes a new Linear Matching Method (LMM) technique for the direct evaluation of cyclic behaviour with creep effects of structures subjected to a general load condition in the steady cyclic state.
Ure, James Michael +2 more
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