The Characterization of Escherichia coli CpdB as a Recombinant Protein Reveals that, besides Having the Expected 3´-Nucleotidase and 2´,3´-Cyclic Mononucleotide Phosphodiesterase Activities, It Is Also Active as Cyclic Dinucleotide Phosphodiesterase. [PDF]
PLoS ONE, 2016 Endogenous cyclic diadenylate phosphodiesterase activity was accidentally detected in lysates of Escherichia coli BL21. Since this kind of activity is uncommon in Gram-negative bacteria, its identification was undertaken.
Iralis López-Villamizar +6 more
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Cyclic J-integral using the linear matching method [PDF]
, 2013 The extended version of the latest Linear Matching Method (LMM) has the capability to evaluate the stable cyclic response, which produces cyclic stresses, residual stresses and plastic strain ranges for the low cycle fatigue assessment with cyclic load ...
Chen, Haofeng, Chen, Weihang
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cGAS-like receptors drive a systemic STING-dependent host response in Drosophila
Cell ReportsSummary: cGAS-like receptor (cGLR)-stimulator of interferon genes (STING) recently emerged as an important pathway controlling viral infections in invertebrates. However, its exact contribution at the organismal level remains uncharacterized.
Xianlong Ai +16 more
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Synthesis of Amide-Linked Cyclic Dinucleotide Analogues with Pyrimidine Bases
, 2017 A convenient procedure has been developed for the synthesis of C-2-symmetrical cyclic dinucleotide analogues that contain all-pyrimidine bases (cytosine, uracil and thymine) with amide bonds in place of natural phosphodiester linkages, starting from ...
Pal, Chandan +3 more
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Human Vaccines & ImmunotherapeuticsHerpes zoster is caused by the reactivation of latent varicella-zoster virus (VZV), primarily affecting middle-aged and older individuals and often accompanied by severe pain and other complications. Vaccination is an effective preventive measure against
Jing-Xing Yang +13 more
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Cyclic cohomology after the excision theorem of Cuntz and Quillen [PDF]
, 2013 The excision theorem of Cuntz and Quillen established the existence of a six term exact sequence in the bivariant periodic cyclic cohomology HP*(–,–) associated with an arbitrary algebra extension 0 ? S ? P ? Q ? 0.
Jacek Brodzki, Brodzki, Jacek
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Structural Basis for Molecular Discrimination by a 3′,3′-cGAMP Sensing Riboswitch
Cell Reports, 2015 Cyclic dinucleotides are second messengers that target the adaptor STING and stimulate the innate immune response in mammals. Besides protein receptors, there are bacterial riboswitches that selectively recognize cyclic dinucleotides.
Aiming Ren +6 more
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Biophysical and Biochemical Applications of Isomorphic Fluorescent Cyclic Dinucleotide Analogs [PDF]
, 2019 As cyclic dinucleotides’ impact on pathogenic bacteria and eukaryotic cells is gradually being recognized, shedding light on the enzymatic pathways involved in its production, degradation and recognition is of significance.
Li, Yao
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European Journal of Histochemistry, 2012 In Dictyostelium discoideum (D. discoideum), compounds generating nitric oxide (NO) inhibit its aggregation and differentiation without altering cyclic guanosine monophosphate (cGMP) production.
A. Amaroli, M.G. Chessa
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Architectures of cyclic dinucleotide phosphodiesterases of different classes.
, 2016 For comparison with CpdB, six proteins representative of previously known cyclic dinucleotide phosphodiesterases are shown with their catalytic domains highlighted (grey): two EAL domain proteins of different architecture, a membrane-bound and a soluble ...
Alicia Cabezas (148477) +6 more
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