Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING
Nature Communications, 2023 The cyclic GMP-AMP synthase (cGAS)/stimulator of interferon gene (STING) signaling pathway plays a critical protective role against viral infections. Metazoan STING undergoes multilayers of regulation to ensure specific signal transduction.
Mei-Hui Hou +11 more
doaj +1 more source
TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity
mAbs, 2022 Cluster of differentiation 38 (CD38) is an ecto-enzyme expressed primarily on immune cells that metabolizes nicotinamide adenine dinucleotide (NAD+) to adenosine diphosphate ribose or cyclic ADP-ribose and nicotinamide.
Harshad S. Ugamraj +19 more
doaj +1 more source
Cyclic J integral using linear matching method [PDF]
, 2012 The extended version of the latest Linear Matching Method (LMM) has the capability to evaluate the stable cyclic response, which produces cyclic stresses, residual stresses and plastic strain ranges for the low cycle fatigue assessment with cyclic load ...
Chen, Haofeng, Chen, Weihang
core +3 more sources
Peptide Coacervates Promote Cytosolic Delivery of STING Agonists for Cancer Immunotherapy
VaccinesBackground/Objectives: Cyclic dinucleotide stimulator of interferon genes (STING) agonists have emerged as potential agents in cancer immunotherapy, but their clinical applications are limited by relatively poor pharmacokinetic properties.
Wenlv Zheng +7 more
doaj +1 more source
Bacteriophage antidefense genes that neutralize TIR and STING immune responses
Cell Reports, 2023 Summary: Programmed cell suicide of infected bacteria, known as abortive infection (Abi), serves as an immune defense strategy to prevent the propagation of bacteriophage viruses.
Peiyin Ho +5 more
doaj +1 more source
Molecular characterization of novel ADP-ribosyl cyclases from the sea urchin [PDF]
, 2010 Calcium signalling is ubiquitous and regulates diverse cellular processes. Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are second messengers that are involved in calcium release from the intracellular organelles ...
Ramakrishnan, L.
core
STING mediates immune responses in the closest living relatives of animals
eLife, 2021 Animals have evolved unique repertoires of innate immune genes and pathways that provide their first line of defense against pathogens. To reconstruct the ancestry of animal innate immunity, we have developed the choanoflagellate Monosiga brevicollis ...
Arielle Woznica +5 more
doaj +1 more source
eLife, 2019 A newfound signaling pathway employs a GGDEF enzyme with unique activity compared to the majority of homologs associated with bacterial cyclic di-GMP signaling.
Zachary F Hallberg +7 more
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Protocol for identification and validation of 2′3′-cGAMP-binding proteins by photoaffinity probes
STAR Protocols, 2022 Summary: Mammalian cyclic dinucleotide 2′3′-cGAMP functions as a second messenger in innate immune response. Here, we report a protocol to utilize 2′3′-cGAMP photoaffinity probes to capture 2′3′-cGAMP-binding or 2′3′-cGAMP-interacting proteins from HeLa ...
Yingjie Hou +4 more
doaj +1 more source
Signal Transduction of Streptococci by Cyclic Dinucleotide Second Messengers
, 2019 Since the discovery of cyclic dimeric guanosine 3\u27,5\u27-monophosphate (c-di-GMP) in 1987, the role of cyclic dinucleotides in signal pathways has been extensively studied.
Zhengyi Li +6 more
core +1 more source