Results 31 to 40 of about 485,549 (166)
ENPP1, an Old Enzyme with New Functions, and Small Molecule Inhibitors—A STING in the Tale of ENPP1
Molecules, 2019 Ectonucleotide pyrophosphatase/phosphodiesterase I (ENPP1) was identified several decades ago as a type II transmembrane glycoprotein with nucleotide pyrophosphatase and phosphodiesterase enzymatic activities, critical for purinergic signaling. Recently,
Kenneth I. Onyedibe +2 more
doaj +1 more source
SLC19A1 transports immunoreactive cyclic dinucleotides [PDF]
Nature, 2019 The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway3.
Luteijn, Rutger D +10 more
openaire +4 more sources
Nature Communications, 2017 Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor and ...
Jessica Vincent +17 more
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Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase
Molecules, 2014 Nicotinamide adenine dinucleotide (NAD), one of the most important coenzymes in the cells, is a substrate of the signaling enzyme CD38, by which NAD is converted to a second messenger, cyclic ADP-ribose, which releases calcium from intracellular calcium ...
Shengjun Wang +8 more
doaj +1 more source
Cyclic dinucleotides at the forefront of innate immunity
Current Opinion in Cell Biology, 2020 Cyclic dinucleotides (CDNs) have emerged as ubiquitous signaling molecules in all domains of life. In eukaryotes, CDN signaling systems are evolutionarily ancient and have developed to sense and respond to pathogen infection. On the other hand, dysregulation of these pathways has been implicated in the pathogenesis of autoimmune diseases.
Shivam A, Zaver, Joshua J, Woodward
openaire +3 more sources
Cyclic Dinucleotides and the Innate Immune Response [PDF]
Cell, 2013 Cyclic dinucleotides (CDNs) have been previously recognized as important secondary signaling molecules in bacteria and, more recently, in mammalian cells. In the former case, they represent secondary messengers affecting numerous responses of the prokaryotic cell, whereas in the latter, they act as agonists of the innate immune response. Remarkable new
Danilchanka, Olga, Mekalanos, John J.
openaire +2 more sources
Single amino acid change in STING leads to constitutive active signaling.
PLoS ONE, 2015 The production of cytokines by the immune system in response to cytosolic DNA plays an important role in host defense, autoimmune disease, and cancer immunogenicity.
Eric D Tang, Cun-Yu Wang
doaj +1 more source
Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 Oral cavity acts as a reservoir of bacterial pathogens for systemic infections and several oral microorganisms have been linked to systemic diseases. Quorum sensing and cyclic dinucleotides, two "decision-making" signaling systems, communicate to regulate physiological process in bacteria.
Ulvi K. Gürsoy +4 more
openaire +4 more sources
Mechanisms of cyclic dinucleotide signaling: from prokaryotes to humans [PDF]
, 2015 Cyclic dinucleotides (cdNs) are novel second messengers that are synthesized directly from two “molecular units of energy” in the cell, namely ATP and GTP. In prokaryotes, all three combinations of cdNs have been discovered: cyclic di-AMP, cyclic AMP-GMP,
Wilson, Stephen
core +1 more source
Frontiers in Immunology, 2020 Stimulator of interferon genes (STING) plays a central role in innate immune responses to viral and intracellular bacterial infections, and cellular damage. STING is a cytosolic sensor of cyclic dinucleotides (CDNs) including those produced by pathogenic
Melissa M. Walker +9 more
doaj +1 more source