Results 11 to 20 of about 485,549 (166)

STING cyclic dinucleotide sensing originated in bacteria [PDF]

Nature, 2020
Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic dinucleotides that are released during bacterial infection and in endogenous cyclic GMP-AMP signalling during viral infection and anti-tumour immunity1-5. STING shares no structural homology with other known signalling proteins6-9, which has limited attempts ...
Benjamin R. Morehouse, Apurva A. Govande, Adi Millman, Alexander F. A. Keszei, Brianna Lowey, Gal Ofir, Sichen Shao, Rotem Sorek, Philip J. Kranzusch   +8 more
core   +9 more sources

Inhibitors of Cyclic Dinucleotide Phosphodiesterases and Cyclic Oligonucleotide Ring Nucleases as Potential Drugs for Various Diseases [PDF]

Cells
The phosphodiester linkage is found in DNA, RNA and many signaling molecules, such as cyclic mononucleotide, cyclic dinucleotides (CDNs) and cyclic oligonucleotides (cONs). Enzymes that cleave the phosphodiester linkage (nucleases and phosphodiesterases)
Christopher S. Vennard, Samson Marvellous Oladeji, Herman O. Sintim   +2 more
doaj   +3 more sources

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING [PDF]

Cell Reports, 2013
The presence of foreign DNA in the cytosol of mammalian cells elicits a potent antiviral interferon response. Recently, cytosolic DNA was proposed to induce the synthesis of cyclic GMP-AMP (cGAMP) upon binding to an enzyme called cGAMP synthase (cGAS ...
Elie J. Diner, Dara L. Burdette, Stephen C. Wilson, Kathryn M. Monroe, Colleen A. Kellenberger, Mamoru Hyodo, Yoshihiro Hayakawa, Ming C. Hammond, Russell E. Vance   +8 more
doaj   +2 more sources

Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport [PDF]

Nature Communications
The solute carrier protein SLC19A1 is crucial for transporting folate nutrients, antifolate chemotherapeutics, and more recently cyclic dinucleotides (CDNs) immune transmitters, influencing various physiological and pathological processes.
Qixiang Zhang, Xuyuan Zhang, Kexin Liu, Yalan Zhu, Xiaohua Nie, Junxiao Ma, Panpan Sun, Zhaolong Li, Yina Gao, Songqing Liu, Ang Gao, Liguo Zhang, Pu Gao   +12 more
doaj   +2 more sources

Exploration of the Binding Mechanism of Cyclic Dinucleotide Analogs to Stimulating Factor Proteins and the Implications for Subsequent Analog Drug Design [PDF]

Biomolecules
Cyclic dinucleotides (CDNs) are cyclic molecules consisting of two nucleoside monophosphates linked by two phosphodiester bonds, which act as a second messenger and bind to the interferon gene stimulating factor (STING) to activate the downstream ...
Shu-Wei Yuan, Hong-Ling Shi, Mu-Ran Fu, Xi-Chuan Zhang, Xiao-Qi Xi, Yao Wang, Tai-Song Shen, Jin-Liang Ma, Cun-Duo Tang   +8 more
doaj   +2 more sources

A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells [PDF]

Nature Communications, 2020
Cyclic dinucleotides are conserved second messengers but current detection methods are limited. Here the authors engineer a Förster resonance energy transfer (FRET) based biosensor, BioSTING, which gives real-time in vitro detection of these nucleotides.
Alex J. Pollock, Shivam A. Zaver, Joshua J. Woodward   +2 more
doaj   +2 more sources

An emerging role for cyclic dinucleotide phosphodiesterase and nanoRNase activities in Mycoplasma bovis: Securing survival in cell culture. [PDF]

PLoS Pathogens, 2020
Mycoplasmas are host-restricted prokaryotes with a nearly minimal genome. To overcome their metabolic limitations, these wall-less bacteria establish intimate interactions with epithelial cells at mucosal surfaces.
Xifang Zhu, Eric Baranowski, Yaqi Dong, Xixi Li, Zhiyu Hao, Gang Zhao, Hui Zhang, Doukun Lu, Muhammad A Rasheed, Yingyu Chen, Changmin Hu, Huanchun Chen, Eveline Sagné, Christine Citti, Aizhen Guo   +14 more
doaj   +2 more sources

RECONsidering Sensing of Cyclic Dinucleotides [PDF]

Immunity, 2017
Detection of cyclic dinucleotides (cdNs) by the STING pathway potently triggers the antiviral response. McFarland et al. now show that the mouse oxidoreductase RECON acts as a sensor for some bacterial cdNs, modulating innate signaling in a manner independent of STING to promote an antibacterial state.
Maelfait, J, Rehwinkel, J
openaire   +3 more sources

Cyclic AMP signalling in pancreatic islets [PDF]

, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Pyne, Nigel J., Ong, Wee Kiat, Furman, Brian   +2 more
core   +4 more sources

P(III) vs. P(V): A P(V) Reagent for Thiophosphoramidate Linkages and Application to An Asymmetric Synthesis of a Cyclic Dinucleotide STING Agonist [PDF]

, 2021
A highly stereoselective synthesis of a cyclic dinucleotide (CDN) STING agonist containing two chiral thiophosphoramidate linkages is described. These rare, yet key functional groups were, for the first time, installed efficiently and with high ...
Bin, Zheng, Geoffrey, Purdum, Miao, Yu, Martin, Eastgate, Benjamin, Hritzko, Changxia, Yuan, Hyunsoo, Park, HuaChia, Tai, Chao, Hang, Benjamin, Cohen, Guanghui, Zhu, Siwei, Guo, Sloan, Ayers, Weiqing, Fu, Ye, Zhu, Amanda, Rogers, Jason, Zhu, Jonanthan, Shackman, James, Paulson, Daniel, Treitler, Brian, He, Melda, Sezen-Edmonds, Qinggang, Wang, Adam, Freitag, Michael A., Schmidt   +24 more
core   +2 more sources