Results 21 to 30 of about 485,549 (166)

Biotechnological production of cyclic dinucleotides—Challenges and opportunities [PDF]

Biotechnology and Bioengineering, 2022
AbstractCyclic dinucleotides (CDNs) are widely used secondary signaling molecules in prokaryotic and eukaryotic cells. As strong agonists of the stimulator of interferon genes, they are of great interest for pharmaceutical applications. In particular, cyclic‐GMP‐AMP and related synthetic CDNs are promising candidates in preclinical work and even some ...
Bartsch, Tabea, Becker, Martin, Rolf, Jascha, Rosenthal, Katrin, Lütz, Stephan   +4 more
openaire   +3 more sources

The World of Cyclic Dinucleotides in Bacterial Behavior [PDF]

Molecules, 2020
The regulation of multiple bacterial phenotypes was found to depend on different cyclic dinucleotides (CDNs) that constitute intracellular signaling second messenger systems. Most notably, c-di-GMP, along with proteins related to its synthesis, sensing, and degradation, was identified as playing a central role in the switching from biofilm to ...
Aline Dias da Purificação, Nathalia Marins de Azevedo, Gabriel Guarany de Araujo, Robson Francisco de Souza, Cristiane Rodrigues Guzzo   +4 more
openaire   +3 more sources

An atypical GdpP enzyme linking cyclic nucleotide metabolism to osmotic tolerance and gene regulation in Mycoplasma bovis

Frontiers in Microbiology, 2023
Nucleotide second messengers play an important role in bacterial adaptation to environmental changes. Recent evidence suggests that some of these regulatory molecular pathways were conserved upon the degenerative evolution of the wall-less mycoplasmas ...
Xifang Zhu, Xifang Zhu, Xifang Zhu, Eric Baranowski, Zhiyu Hao, Xixi Li, Gang Zhao, Yaqi Dong, Yingyu Chen, Changmin Hu, Huanchun Chen, Huanchun Chen, Huanchun Chen, Huanchun Chen, Christine Citti, Aiping Wang, Aiping Wang, Aizhen Guo, Aizhen Guo, Aizhen Guo, Aizhen Guo   +20 more
doaj   +1 more source

RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies [PDF]

, 2014
Mutating RNA virus genomes to alter codon pair (CP) frequencies and reduce translation efficiency has been advocated as a method to generate safe, attenuated virus vaccines.
David J Evans, Fiona Tulloch, Evans, David John, Tulloch, F., Ryan, M. D., Atkinson, N. J., Ryan, Martin D., Tulloch, Fiona, Martin D Ryan, Simmonds, Peter, Nicky J Atkinson, Atkinson, Nicky J., Peter Simmonds, Evans, David J., Simmonds, P., Evans, D. J.   +15 more
core   +1 more source

Molecular Characterization of a Novel Intracellular ADP-Ribosyl Cyclase [PDF]

, 2007
Background. ADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Jonathan S Marchant, Marchant, JS, Michael J Boulware, Dev Churamani, Churamani, D, Dale, L, Geach Timothy J., Martin Andrew C.R., Gary W Moy, Andrew C R Martin, Sandip Patel, Dale Leslie, Yi-Hsien Su, Vacquier, VD, Vacquier Victor D., Su, YH, Patel Sandip, Churamani Dev, Boulware, MJ, Marchant Jonathan S., Leslie Dale, Boulware Michael J., Moy Gary W., Patel, S, Geach, TJ, Su Yi-Hsien, Moy, GW, Timothy J Geach, Martin, ACR, Victor D Vacquier   +29 more
core   +1 more source

Activation of STING Based on Its Structural Features

Frontiers in Immunology, 2022
The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a hallmark of infection or cancers.
Behzad Hussain, Yufeng Xie, Uzma Jabeen, Defen Lu, Bo Yang, Bo Yang, Changxin Wu, Guijun Shang, Guijun Shang   +8 more
doaj   +1 more source

Intercepting Cyclic Dinucleotide Signaling with Small Molecules [PDF]

, 2016
Bacterial infections, especially the ones that are caused by multidrug-resistant strains, are becoming increasingly difficult to treat and put enormous stress on healthcare systems.
Zheng, Yue
core   +1 more source

ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance

Communications Biology, 2021
Su Chul Jang et al. develop exoSTING, consisting of an engineered extracellular vesicle loaded with a potent cyclic dinucleotide (CDN) agonist of the STING pathway.
Su Chul Jang, Kyriakos D. Economides, Raymond J. Moniz, Chang Ling Sia, Nuruddeen Lewis, Christine McCoy, Tong Zi, Kelvin Zhang, Rane A. Harrison, Joanne Lim, Joyoti Dey, Marc Grenley, Katherine Kirwin, Nikki L. Ross, Raymond Bourdeau, Agata Villiger-Oberbek, Scott Estes, Ke Xu, Jorge Sanchez-Salazar, Kevin Dooley, William K. Dahlberg, Douglas E. Williams, Sriram Sathyanarayanan   +22 more
doaj   +1 more source

The Promise and Challenges of Cyclic Dinucleotides as Molecular Adjuvants for Vaccine Development

Vaccines, 2021
Cyclic dinucleotides (CDNs), originally discovered as bacterial second messengers, play critical roles in bacterial signal transduction, cellular processes, biofilm formation, and virulence. The finding that CDNs can trigger the innate immune response in
Hongbin Yan, Wangxue Chen
doaj   +1 more source

An investigation of NAADP-dependent Ca²⁺ signalling mechanisms in arterial smooth muscle [PDF]

, 2007
Previous investigations on pulmonary artery smooth muscle cells have shown that nicotinic acid adenine dinucleotide diphosphate (NAADP) evokes highly localised intracellular Ca²⁺ bursts by mobilising thapsigargin-insensitive Ca²⁺ stores.
Kinnear, Nicholas P.
core   +2 more sources