Results 91 to 100 of about 18,412 (234)

Synthesis and binding studies of two new macrocyclic receptors for the stereoselective recognition of dipeptides

Beilstein Journal of Organic Chemistry, 2010
We present here the design, synthesis, and analysis of a series of receptors for peptide ligands inspired by the hydrogen-bonding pattern of protein β-sheets.
Ana Maria Castilla, M. Morgan Conn, Pablo Ballester   +2 more
doaj   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Stabilization of angiotensin-(1-7) by key substitution with a cyclic non-natural amino acid [PDF]

, 2017
Angiotensin-(1-7) [Ang-(1-7)], a heptapeptide hormone of the renin-angiotensin-aldosterone system (RAAS), is a promising candidate as a treatment for cancer that reflects its antiproliferative and anti-angiogenic properties.
AC Marshall, AC Marshall, Anita Wester, B Krishnan, B Krishnan, DR Soto-Pantoja, E O’Reilly, E. Ann Tallant, Francesca Paradisi, H Pham, I Lula, J Menon, KE Rodgers, KL Cook, L Ni, LD Kluskens, Marc Devocelle, Mark C. Chappell, MC Chappell, MC Chappell, N Cruz-Diaz, NM Silva-Barcellos, Patricia E. Gallagher, PE Gallagher, PE Gallagher, RA Fraga-Silva, RAS Santos, WJ Petty, WJ Petty, Z Paryzek   +29 more
core   +2 more sources

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, EarlyView.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Photoprotective Effects of Yeast Pulcherrimin

Molecules
Sunscreen products can protect the skin against the harmful effects of UV radiation, including reddening, aging, and cancer. The aim of this research was to evaluate the photoprotective effects of yeast pulcherrimin, an iron-chelating dipeptide. We first
Dorota Kregiel, Agnieszka Krajewska, Agnieszka Kowalska-Baron, Karolina H. Czarnecka-Chrebelska, Adriana Nowak   +4 more
doaj   +1 more source

Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides. [PDF]

J Pept Sci
As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Moriyama Y, Sada H, Nanjo T.
europepmc   +2 more sources

It's a Gas: Bioconjugation With Vapor‐Phase Reagents

Chemistry – A European Journal, EarlyView.
Gaseous reagents are an emerging class of bioconjugation reagents that can offer alternative selectivity paradigms for the construction of precise bioconjugates. A variety of both inert and highly reactive gases have recently been developed for bioconjugation use.
Yuxuan Ding, Jun Ohata, Zachary T. Ball
wiley   +1 more source

Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I [PDF]

, 2001
Linear and cyclic hymenistatin I (HS I) analogues with dipeptide segments Ile2-Pro3, Pro3-Pro4 and Val6-Pro7 replaced by their tetrazole analogues Ile-Ψ[CN4]-Ala3, Pro3-Ψ[CN4]-Ala4 and Val6-Ψ[CN4]-Alawere synthesized by the solid phase peptide synthesis ...
Kociolek, K., Kowalski, M.L., Silberring, J., Smoluch, M.T., Szkudlinska, B., Zabrocki, J., Zubrzak, P.   +6 more
core   +1 more source

Cyclization of Fungal Nonribosomal Peptides by a Terminal Condensation-Like Domain [PDF]

, 2012
Cyclization of linear peptidyl precursors produced by nonribosomal peptide synthetases (NRPSs) is an important step in the biosynthesis of bioactive cyclic peptides. Whereas bacterial NRPSs use thioesterase (TE) domains to perform the cyclization, fungal
Ames, Brian D., Gao, Xue, Haynes, Stuart W., Tang, Yi, Vien, Linda P., Walsh, Christopher T., Wang, Peng   +6 more
core   +1 more source

Chirality Effects in Jet-Cooled Cyclic Dipeptides [PDF]

, 2019
Jet-cooled bichromophoric cyclic dipeptides built on a diketopiperazine (DKP) ring are studied by combining conformer-specific vibrational spectroscopy with quantum chemical calculations. The dependence of the c-LL and c-LD dipeptides structure upon relative absolute configuration, L or D, of the residues is investigated for two residues: phenylalanine
Ariel Pérez-Mellor, Anne Zehnacker
openaire   +1 more source