Results 131 to 140 of about 18,412 (234)

Preparation of Novel Hydroxyethyl Amine Isosteres as Potential Cathepsin D Inhibitors [PDF]

, 2002
Cathepsin D is a lysosomal aspartic protease found in all mammalian cells and is considered to be one of the main catabolic proteinases. Cathepsin D has been suggested to play a role in the metastatic potential of several types of cancer.
Godwin, Walter E., Goss, Crissy, Herring, Nikki, McConnell, Rose M., Newton, Crystal, Stefan, Amy   +5 more
core   +1 more source

A Lavandula angustifolia flower extract and dipeptide‐4 blend modulates oxidative, glycative, autophagic and circadian pathways in human skin models

International Journal of Cosmetic Science, EarlyView.
The blend enhanced antioxidation, anti‐glycation, autophagy and circadian regulation in cell and skin models. Key markers included mitochondrial ROS, γ‐H2AX, AGEs, ATP, melatonin, LC3 and SOD. Significant improvements were visualized via fluorescence and quantified with statistical markers.
Lina Wang, Yuxuan Wu, Huiping Hu, Yanan Li, Peiwen Sun   +4 more
wiley   +1 more source

The PagDMG6341–PagWD40–PagPOLD4 Module Coordinates Base Excision Repair in ‘84K’ Poplar (Populus alba × P. glandulosa)

Plant Biotechnology Journal, EarlyView.
ABSTRACT Base excision repair (BER) is a critical pathway for repairing damaged DNA bases in cells; however, the mechanisms of protein recruitment and interaction in this pathway remain largely unexplored in higher plants. In this study, we used ‘84K’ poplar (Populus alba × P.
Aoyu Ling, Yijia Jin, Yufei Xia, Shenxiu Jiang, Jianghai Shu, Xiaotong Hu, Kang Du, Pingdong Zhang, Xiangyang Kang   +8 more
wiley   +1 more source

(Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
In this review, we spotlight recent breakthroughs in α‐polyboron‐substituted carbon‐centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundamental reactivity with the application potential of these extraordinary species, we hope this review will serve as a roadmap for harnessing these unique ...
Nadim Eghbarieh, Nicole Hanania, Pinaki Nad, Tipu Alam, Tamir Kish, Ahmad Masarwa   +5 more
wiley   +2 more sources

Pyrene‐Conjugated, 2‐Pyridinecarboxaldehyde Derivatives as N‐Terminus‐Specific Tags for MALDI‐ and LALDI‐MS

Rapid Communications in Mass Spectrometry, Volume 40, Issue 8, 30 April 2026.
ABSTRACT Background Proteolytic processing is a fundamental post‐translational modification. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) workflows are powerful for degradomic analyses but inherently sacrifice spatial information, a critical aspect for investigating biological systems such as aberrant extracellular matrix remodeling and ...
Mujia Jenny Li, Murat Kucukdisli, Florian Braun, David W. Will, Nadine Meier, Bettina Wehrle, Larissa Chiara Meyer, Melanie Christine Föll, Oliver Schilling   +8 more
wiley   +1 more source

Revision of the genus Aciculosporium (Clavicipitaceae) with a description of a new species on wavyleaf basketgrass, and proline-containing cyclic dipeptide production by A. take. [PDF]

Mycoscience, 2021
Tanaka E, Hosoe T, Degawa Y, Kolařík M.   +3 more
europepmc   +1 more source

Molecular Mechanisms of Algicidal Bacteria in Controlling Harmful Algal Blooms: Advances in Bacteria‐Algae Interactions

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
This review elucidates the molecular mechanisms of algicidal bacteria, highlighting critical behaviours like chemotaxis, quorum sensing and extracellular vesicle release. It details how these actions disrupt algal cellular integrity, photosynthesis and calcium homeostasis, providing a theoretical foundation for controlling harmful algal blooms ...
Jiaxin Wang, Binfu Xu, Lixing Huang
wiley   +1 more source

Three New Dipeptide and Two New Polyketide Derivatives from the Mangrove-Derived Fungus Talaromyces sp.: Antioxidant Activity of Two Isolated Substances

Marine Drugs
Five new metabolites, including three cyclic dipeptide derivatives (1–3) and two new polyketides (10–11), together with nine known ones (4–9 and 12–15), were isolated from the mangrove-sediments-derived fungus Talaromyces sp. SCSIO 41431.
Zhihao Zeng, Jian Cai, Yi Chen, Xinlong Li, Chunmei Chen, Yonghong Liu, Lalith Jayasinghe, Xuefeng Zhou   +7 more
doaj   +1 more source

Visible‐Light Mediated Functionalization in Phe‐Containing Peptides Upon a Debenzylative Amination Process

Advanced Synthesis &Catalysis, Volume 368, Issue 6, 17 March 2026.
Selective late‐stage modification of N‐terminal phenylalanine short peptides is achived by visible‐light initiated reaction with N‐iodoimides in a debenzylation–amination process. This metal‐free method permits the incorporation of N‐containing heterocycles into the α‐position of the peptide backbone.
Guillermo Morales‐Ortega, Iván Pérez‐Cubero, Enrique Gómez‐Bengoa, Arkaitz Correa, Javier Carreras   +4 more
wiley   +1 more source

Self‐Immolative Systems in Diagnostic and Therapeutic Applications

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo, Thomas Cailly, Valérie Collot   +2 more
wiley   +1 more source