Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li +3 more
wiley +1 more source
DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu +6 more
wiley +1 more source
Chemoselective C-Terminal Activation Platform for Direct Conversion of Native Linear Peptides into Thiazoline/Thiazole Macrocycles. [PDF]
Le BQG, Kwon M, Raj M.
europepmc +1 more source
This review outlines the role of innovative technologies in valorizing the waste generated from different plant waste streams into protein‐rich ingredients and modifying their conformational structure to improve the techno‐functional attributes including hydration, emulsification, foaming, gelation, and nutritional value.
Subith Cheeyattil +5 more
wiley +1 more source
Outer‐Sphere Tuning of Synthetic Iron–Sulfur Clusters Within Nanoscale Cage Frameworks
Noncovalent encapsulation of a synthetic iron–sulfur cluster within hydrophobic, naphthalenediimide (NDI)‐paneled cages is shown to lead to dramatic changes in the electronic structure and covalency of the Fe─S core. ABSTRACT As atomic‐scale archetypes for multi‐electron transfer, iron–sulfur clusters are compelling candidates for the design of redox ...
Rupal Baliyan +3 more
wiley +1 more source
Celebrating Young Investigators in Peptide Science. [PDF]
Lubell WD, Wade JD, Rovero P.
europepmc +1 more source
From Heritage to Innovation: A Review of the Safety and Production of Aminopeptide Seasonings
ABSTRACT Aminopeptide seasonings, produced through proteolytic fermentation or enzymatic hydrolysis, represent a global family of ingredients with a high concentration of umami‐active free amino acids and umami‐ or kokumi‐active peptides derived from protein‐rich substrates.
José María Martín‐Miguélez +4 more
wiley +1 more source
Pulcherriminic acid as an antibiofilm effector: expanding <i>Bacillus</i> functionality against yeast biofilms. [PDF]
Srinivasan R +4 more
europepmc +1 more source
Introducing a phosphoketolase pathway into Bacillus methanolicus enhances methanol‐to‐biomass yields by 18%–24% and reduces CO2 evolution by up to 12%. Coupled with a tunable expression system, this work demonstrates improved carbon conservation and expands metabolic engineering strategies for methylotrophs.
Yael J. Toporek +6 more
wiley +1 more source
Analysis of the genome of a Pseudomonas monsensis isolate that produces the antifungal dipeptide maculosin. [PDF]
Sharma P +10 more
europepmc +1 more source

