Results 161 to 170 of about 8,341 (207)
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EMPIRICAL CALCULATIONS ON CYCLIC DIPEPTIDES
International Journal of Peptide and Protein Research, 1980Empirical conformational energy calculations were carried out for the dipeptides cyclo‐(L‐Asp‐L‐His) and cyclo‐(L‐Glu‐L‐His). The side chain conformations have been studied for various DKP ring structures, demonstrating that distortions can modify the stability of some conformations by favouring peptide backboneside chain or side chain ‐ side chain ...
M. GENEST, M. PTAK
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Cyclic dipeptides exhibit potency for scavenging radicals
Bioorganic & Medicinal Chemistry, 2012Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against ·OH and O(2)(·-) was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against ·OH than vitamin E. However, only cyclo(l-Cys-l-Leu) scavenged O(2)
Tadashi, Furukawa +6 more
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The optical properties of tyrosine‐containing cyclic dipeptides
Biopolymers, 1977AbstractThe chiroptical properties of the cyclic dipeptides cyclo (L‐alanyl‐L‐tyrosine) and cyclo(L‐tyrosyl‐L‐tyrosine) have been investigated as a function of molecular conformation. Theoretical optical calculations and conformational energy calculations have been carried out as a function of the side‐chain dihedral angles χ1 and χ2, and as a function
J W, Snow, T M, Hooker, J A, Schellman
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Synthesis of New Functionalized Cyclic Dipeptide
Synthetic Communications, 1997Abstract An efficient method has been developed for the synthesis of the functionalized cyclic dipeptide 6. The key step involves cyclisation of the linear dipeptide prepared by coupling a suitably protected β-amino acid with N-benzyl-t-butylglycinate.
O. El Mahdi +4 more
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EMPIRICAL CALCULATIONS ON CYCLIC DIPEPTIDES
International Journal of Peptide and Protein Research, 1978Empirical conformational energy calculations were carried out for the dipeptides cyclo‐(L‐Ser‐L‐His) and cyclo‐(L‐Thr‐L‐His). Various DKP structures have been investigated to study side chain conformations through the DKP ring deformations, and prevalent conformers of monosubstituted and disubstituted dipeptides are discussed.
M, Genest, M, Ptak
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Two-Dimensional Coordination Networks from Cyclic Dipeptides
Journal of the American Chemical Society, 2020Peptide-based biomimetic nanostructures and metal-organic coordination networks on surfaces are two promising classes of hybrid materials which have been explored recently. However, despite the great versatility and structural variability of natural and synthetic peptides, the two directions have so far not been merged in fabrication of metal-organic ...
Yuanyuan Guo +4 more
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Quantum chemical study of cyclic dipeptides
International Journal of Quantum Chemistry, 2006AbstractThe preferred conformations of cyclic dipeptides were first studied systemically using the density functional theory (DFT) B3LYP method at the 6‐31G(d) level. The structural characteristics of cyclic dipeptides were revealed, most of which have not been confirmed until now.
Yanyan Zhu +3 more
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Synthesis of cyclic ketomethylene dipeptide derivatives
Tetrahedron, 1992—Methyl 6-aralkyl-2,5-diketopiperidine-3-carboxylates derived from L-Phe and L-Trp, and their 3-substituted analogues in which the 3-substituent is the side chain of Phe, Asp and Ala have been synthesized. Cycle[Trpψ(COCH2)Gly] and cycle[Pheψ(COCH2)-ξ-Phe] have been also prepared.3-Substituted methyl 6-arakyl-2,5-diketopiperidine-3-carboxylates 11ab ...
Domínguez, María José +2 more
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Antimicrobial activity of selected cyclic dipeptides.
Die Pharmazie, 1999Cyclic dipeptides are products of rational drug design, which may exhibit both antimicrobial and antitumor properties. The aim of this study was to investigate both the antimicrobial effects of the cyclic dipeptides cyclo(L-phenylalanyl-L-prolyl), cyclo(L-tyrosyl-L-prolyl), cyclo(L-tryptophanyl-L-prolyl) and cyclo(L-tryptophanyl-L-tryptophanyl) and the
M, Graz +4 more
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Analysis of the biosynthesis of antibacterial cyclic dipeptides in Nocardiopsis alba
Archives of Microbiology, 2014Nocardiopsis alba is frequently isolated from environment and has recently been suggested as a casual symbiotic actinobacterium of diverse invertebrates. Using activity-guided fractionation, we purified two antibacterial cyclic dipeptides, cyclo(ΔPhe-ΔLeu) (albonoursin) and cyclo(ΔmTyr-ΔLeu), from a culture of Nocardiopsis alba ATCC BAA-2165.
Yongli, Li +4 more
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