Results 151 to 160 of about 863,677 (247)

Stimulating proteasomal degradation in human proteinopathies

The FEBS Journal, Volume 293, Issue 18, Page 5514-5540, September 2026.
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch, Enrica Barchi, Nico P. Dantuma   +2 more
wiley   +1 more source

Identification of Antibacterial Cyclic Peptides with a High-Throughput Cell-Based Dropout Screen. [PDF]

J Am Chem Soc
Windeln LM, Mitchell LW, Wisniewska AB, McDermott A, Walker SS, Walji AM, Tavassoli A.   +6 more
europepmc   +1 more source

Neutrophil Secretory Proteins Inhibit Calcium Oxalate Crystallisation and Crystal Growth, but Promote Crystal Aggregation

Immunology, Volume 179, Issue 1, Page 101-117, September 2026.
Calcium oxalate monohydrate (COM) crystals cause changes in the secretion of 29 proteins from neutrophil‐like cells, including those involved in neutrophil immune activation and intracellular metabolic adaptation. The neutrophil secreted proteins (secretome) also inhibit calcium oxalate crystallisation and crystal growth, but promote crystal ...
Chanettee Lertprapai, Paleerath Peerapen, Visith Thongboonkerd   +2 more
wiley   +1 more source

Chemoenzymatic Modification of Microcin J25 with Single-Residue Precision Provides New-to-Nature Lasso Peptides. [PDF]

JACS Au
Tsai CY, Chung HW, Huang YP, Chang CF, Cheung KY, Tan HN, Huang HY, Sung LK, Hegemann JD, Chan YT, Chu J.   +10 more
europepmc   +1 more source

Prolonging the Efficacy of Botulinum Toxin A Using a Novel Toxin Mimetic Complex and Peptide Formulation

Journal of Cosmetic Dermatology, Volume 25, Issue 9, September 2026.
ABSTRACT Background Botulinum toxin type A (BTX‐A) is the cornerstone for treating dynamic wrinkles; however, it requires reinjection every 3–4 months. Adjunctive topical creams that mimic the effect of BTX‐A and enhance its action may prolong treatment intervals.
Riad Kassem, Tomer Mimouni, Lee Magal, Ziad Khamaysi, Avner Shemer   +4 more
wiley   +1 more source

NbRD21 protease controls receptor kinase homeostasis in Nicotiana benthamiana

New Phytologist, Volume 251, Issue 5, Page 2741-2752, September 2026.
Proteomic analysis revealed that receptor kinases (red) accumulate higher in rd21 knockout Nicotiana benthamiana plants. Summary RD21‐like proteases are papain‐like cysteine proteases with a C‐terminal granulin domain that are abundant and ubiquitous in angiosperms and have often been implicated in immunity.
Alice Godson, Lauren Eddie, Mariana Schuster, Kaijie Zheng, Reka Toth, Yuge Li, Tianrun Li, Jie Huang, Farnusch Kaschani, Philippe V. Jutras, Jiorgos Kourelis, Markus Kaiser, Tolga Bozkurt, Renier A. L. Van der Hoorn   +13 more
wiley   +1 more source

Facile Synthesis of Non-Proteinogenic Sulfur-Containing Cyclic Dipeptides and Their Structure-Antioxidant Activity Relationship. [PDF]

Chem Asian J
M V, Chinta JP.
europepmc   +1 more source

Re‐evaluation of salt of aspartame‐acesulfame (E 962) as food additive

EFSA Journal, Volume 24, Issue 9, September 2026.
Abstract The present opinion deals with the re‐evaluation of salt of aspartame‐acesulfame (E 962) as a food additive. The Panel considered that upon ingestion, E 962 dissociates into aspartame and acesulfame ions which correspond to those of the authorised sweeteners aspartame (E 951) and acesulfame K (E 950). The Panel therefore assessed the safety of
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Rex FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Ellen Bruzell, Cristina Fortes, Kevin James Chipman, Riccardo Crebelli, Peter Fürst, Jean‐Charles Leblanc, Evangelia Ntzani, Andrea Terron, Matthew Wright, Stefania Barmaz, Costanza Bonnici, Consuelo Civitella, Elena Mazzoli, Josef Daniel Rasinger, Ana Rincon, Camilla Smeraldi, Alexandra Tard, Federica Lodi   +34 more
wiley   +1 more source

Dynamics of (Hetero)aryl Motifs: An Integrative Approach To Study the Conformational Landscape in Macrocycles. [PDF]

J Am Chem Soc
Ketzel AF, Diamandas M, Li XL, Ou YD, Lei X, Yudin AK, Sun H.   +6 more
europepmc   +1 more source

Molecular Design of Thermoresponsive Cellulose: How Graft Architecture Dictates Sol-Gel Transitions. [PDF]

Macromol Rapid Commun
Tao S, Liu H, Lin X, Sun Z, Wang X, Qi H.   +5 more
europepmc   +1 more source