Results 41 to 50 of about 18,412 (234)
Enhanced sampling of multidimensional free-energy landscapes using adaptive biasing forces
, 2010 We propose an adaptive biasing algorithm aimed at enhancing the sampling of multimodal measures by Langevin dynamics. The underlying idea consists in generalizing the standard adaptive biasing force method commonly used in conjunction with molecular ...
Chipot, Chris, Lelièvre, Tony
core +3 more sources
Synthesis and Conformational Studies of Peptidomimetics Containing a New Bifunctional Diketopiperazine Scaffold Acting as a \u3b2-Hairpin Inducer [PDF]
, 2008 A practical synthesis of a new bifunctional diketopiperazine (DKP) scaffold 1, formally derived from the cyclization of L-aspartic acid and (S)-2,3-diaminopropionic acid, is reported.
Belvisi, L. +5 more
core +1 more source
The Biological Activity of Selected Cyclic Dipeptides
Journal of Pharmacy and Pharmacology, 1998 Abstract Cyclic dipeptides are widely used as models for larger peptides because of their simplicity and limited conformational freedom. Some cyclic dipeptides have been shown to be antiviral, antibiotic and anti-tumour. The aim of this study was to determine the biological activity of four cyclic dipeptides synthesized in this ...
P J, Milne +4 more
openaire +2 more sources
Sequence‐Modulated Active Tripeptide Condensates for Tandem Catalysis
Angewandte Chemie, EarlyView.Sequence‐modulated tripeptide coacervates mimic biomolecular condensates with controllable, enzyme‐regulated phase separation. They co‐sequester hydrophobic active species and hydrophilic enzymes, enabling tandem catalysis in aqueous media. Incorporated into artificial cells, they function as adaptive sub‐organelles, orchestrating compartmentalized ...
Hao Han +7 more
wiley +2 more sources
Recent research of peptide-based hydrogel in nervous regeneration
Bioactive MaterialsNeurological disorders exert significantly affect the quality of life for patients, necessitating effective strategies for nerve regeneration. Both traditional autologous nerve transplantation and emerging therapeutic approaches encounter scientific ...
Chunmei Xie +7 more
doaj +1 more source
Frontiers in Microbiology, 2020 A new polyketide derivative, nafuredin C (1), a novel heterocyclic dipeptide, trichodermamide G (3), together with four known biogenetically related compounds nafuredin A (2), trichodermamide A (4), aspergillazin A (5), and peniisocoumarin H (6), were ...
Dong-Lin Zhao +9 more
doaj +1 more source
, 2020 The chalcogen elements oxygen, sulfur, and selenium are essential constituents of side chain functions of natural amino acids. Conversely, no structural and biological function has been discovered so far for the heavier and more metallic tellurium ...
Agh R +13 more
core +1 more source
Enzymatical and microbial degradation of cyclic dipeptides (diketopiperazines) [PDF]
AMB Express, 2013 Diketopiperazines (DKPs) are cyclic dipeptides, representing an abundant class of biologically active natural compounds. Despite their widespread occurrence in nature, little is known about their degradation. In this study, the enzymatical and microbial cleavage of DKPs was investigated.
Perzborn, M., Syldatk, C., Rudat, J.
openaire +4 more sources
Angewandte Chemie, EarlyView.This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe +5 more
wiley +2 more sources
Effects of Cyclic High Ambient Temperature on Muscle Imidazole Dipeptide Content in Broiler Chickens
The Journal of Poultry ScienceImidazole dipeptides possess important bioregulatory properties in animals. This study aimed to evaluate the effect of high ambient temperature on muscle imidazole dipeptides (carnosine, anserine, and balenine) in broiler chickens.
Ayumi Katafuchi +8 more
doaj +1 more source