Results 91 to 100 of about 464,022 (216)

Expression and purification of L-asparaginase from Escherichia coli and the inhibitory effects of cyclic dipeptides

, 2017
L-asparaginase, a key enzyme involved in nitrogen metabolism, is an effective anti-tumour agent. Cyclic dipeptides, a group of compounds, contain several important biological functions.
Yanan Zhang (1322391), Dan Li (106345), Yan Li (23143)   +2 more
core   +1 more source

Evaluating the In Vitro Digestibility of Black Soldier Fly (Hermetia illucens L.) Larvae as Potential Feed Ingredient in Dairy Cattle Silage‐Based Diets: A Focus on Proteins

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Dietary protein has a substantial economic impact on cattle feed, and it is also a critical component for animal growth and productivity. Several environmental issues related to soybeans have led to an increased interest in novel protein sources, such as insects.
Maria Giulia Bonomini, Marica Simoni, Matteo Profeti, Federico Righi, Augusta Caligiani   +4 more
wiley   +1 more source

In Silico Evaluation of Diketopiperazine (DPK) Derivatives as Potential Inhibitors for G-Protein-Coupled Receptors (GPCRs)

Medical Sciences Forum
G-protein-coupled receptors (GPCRs) are a group of various membrane proteins that mediate essential physiological processes by translating extracellular signals into intracellular responses.
Sepideh Jafari, Joanna Bojarska
doaj   +1 more source

Self‐Assembly of Therapeutic Peptides for Enhanced Cancer Therapy: Strategies, Therapeutic Performance, and Future Perspectives

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Therapeutic peptide self‐assembly is governed by multiple non‐covalent interactions, enabling the construction of diverse supramolecular structures. These self‐assembled systems can be engineered through spontaneous self‐assembly of monomers, co‐assembly, or stimulus‐responsive strategies to improve tumor delivery efficiency.
Yuelin Fang, Xue Wan, Shihe Wang, Honglan Dai, Huiling Zeng, Nan Chen, Xinxin Zhang   +6 more
wiley   +1 more source

Plant NAOGAT (ArgJ) Structure Reveals Mechanism of Ornithine Biosynthesis, Preference for Acetylornithine and Susceptibility to Mangotoxin

Plant, Cell &Environment, Volume 49, Issue 12, Page 10283-10300, December 2026.
ABSTRACT Arginine metabolism in plants is targeted by phytopathogens such as Pseudomonas syringae strains, which produce toxins that affect enzymes of plant arginine metabolism, causing devastating infections in crops. In this work, the structural and functional properties of plant N‐acetylornithine glutamate acetyltransferase (NAOGAT), the key ...
Maciej Nielipinski, Agnieszka J. Pietrzyk‐Brzezinska, Aleksandra Twarda‐Clapa, Bartosz Sekula   +3 more
wiley   +1 more source

Screening of Various Metabolites in Six Barley Varieties Grown under Natural Climatic Conditions (2016–2018)

Microorganisms, 2019
Climatic changes influence considerably the distribution and occurrence of different secondary metabolites in cereals. The aim of this investigation was to assess the changes in metabolite prevalence observed in six different winter barley varieties over
Kristina Habschied, Rudolf Krska, Michael Sulyok, Bojan Šarkanj, Vinko Krstanović, Alojzije Lalić, Gordana Šimić, Krešimir Mastanjević   +7 more
doaj   +1 more source

Fragment Coverage: Unified Visualization and Quantitative Assessment of MS/MS Fragmentation Supports Metabolite Identification in Macromolecule Drug Metabolism Studies

Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.
ABSTRACT Rationale Peptides and oligonucleotides are increasingly used as therapeutic agents, making the identification and structural elucidation of their metabolites a critical step in drug development. Liquid chromatography–mass spectrometry (LC‐MS/MS) is the primary analytical technique for this purpose; however, extensive backbone fragmentation ...
Paula Cifuentes, Albert Garriga, Fabien Fontaine, Ismael Zamora   +3 more
wiley   +1 more source

Integration of Chemical Probes and Degradomics Reveals That Cathepsin B Functions Primarily as a Dipeptidyl Carboxypeptidase in Macrophages

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
An integrated chemical biology and degradomics approach reveals the proteolytic landscape of cathepsin B in mouse macrophages. Z‐RK‐AOMK perturbs the cysteine cathepsin network and reveals that cathepsin B predominantly exhibits dipeptidyl carboxypeptidase activity in cells.
Kai‐Qi Yek, Francesca L. Apolloni, Bangyan Xu, Nghi H. Nguyen, Alexander R. Ziegler, Nichollas E. Scott, Brad E. Sleebs, Laura E. Edgington‐Mitchell   +7 more
wiley   +1 more source

The high-throughput solid-phase extraction of cis-cyclo(L-Leu-L-Pro) and cis-cyclo(L-Phe-L-Pro) from Lactobacillus plantarum demonstrates efficacy against multidrug-resistant bacteria and influenza A (H3N2) virus

Frontiers in Molecular Biosciences
Introduction2,5-diketopiperazines are the simplest forms of cyclic dipeptides (CDPs) and have diverse frameworks with chiral side chains that are useful for drug development.
Jaeyoung Son, Yeonju Hong, Hyeri Seong, Yoon Sin Oh, Min-Kyu Kwak   +4 more
doaj   +1 more source

Leucine–glycine and carnosine dipeptides prevent diabetes induced by multiple low‐doses of streptozotocin in an experimental model of adult mice

Journal of Diabetes Investigation, 2019
Aims/Introduction Peptides are considered to be quasi‐hormones and effective molecules for regulation of the cells function and prevention of metabolic disorders.
Tohid Vahdatpour, Ali Nokhodchi, Parvin Zakeri‐Milani, Mehran Mesgari‐Abbasi, Naser Ahmadi‐Asl, Hadi Valizadeh   +5 more
doaj   +1 more source