Results 101 to 110 of about 464,022 (216)

Development and testing of liposome encapsulated cyclic dipeptides [PDF]

, 2011
Cyclic dipeptides have been well characterized for their multitude of biological activities, including antimicrobial and anticancer activities. Cyclo(His-Gly) and cyclo(His-Ala) have also recently been shown to possess significant anticancer activity ...
Kilian, Gareth
core  

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3079-3105, November 2026.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Synthesis and binding studies of two new macrocyclic receptors for the stereoselective recognition of dipeptides

Beilstein Journal of Organic Chemistry, 2010
We present here the design, synthesis, and analysis of a series of receptors for peptide ligands inspired by the hydrogen-bonding pattern of protein β-sheets.
Ana Maria Castilla, M. Morgan Conn, Pablo Ballester   +2 more
doaj   +1 more source

Plant‐Derived Probiotics From Fermented Foods: Current Evidence on Antiviral Mechanisms and Gut–Lung Axis Modulation

Food Frontiers, Volume 7, Issue 6, November 2026.
Plant‐derived probiotics from fermented foods exert anti‐respiratory virus effects via immune regulation, antiviral metabolites, and gut–lung axis, highlighting their advantages, key technologies, and application prospects. ABSTRACT Respiratory viral infections represent a major global public health threat, causing widespread morbidity, mortality, and ...
Yinghao Xing, Yaoyuan Hu, Yingying Ma, Peng Yao, Jingjing Jiang, Jiao Guo, Shuangmei Liu   +6 more
wiley   +1 more source

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Substrate‐Dependent Crosslinking by the Cytochrome P450 From Aminopyruvatide Biosynthesis

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
Substitutions in the aminopyruvatide precursor peptide altered the C─C linkage formed from a YLY motif by the P450 ApyO to a N─C linkage in a WLY motif. Moreover, constitutional isomers crosslinked by C─C and C─O linkages were formed from YYY or YWY motifs. ABSTRACT Cytochrome P450s catalyze an array of reactions including crosslinking of aromatic side
Chandrashekhar Padhi, Dinh T. Nguyen, Lingyang Zhu, Lide Cha, Jesse W. Wald, Douglas A. Mitchell, Wilfred A. van der Donk   +6 more
wiley   +2 more sources

Fragmentation and charge transfer in cyclic dipeptides with an aromatic side chain induced by VUV radiation [PDF]

The fragmentation of three cyclic dipeptides (c-Glycil-Phenylalanine, c-Tryptophan-Tyrosine and c-Tryptophan-Tryptophan), characterized by an aromatic side chain, has been investigated by synchrotron radiation and photoelectron-photoion coincidence ...
Nisoli M., Casavola A. R., Wu Y., Borrego-Varillas R., Singh M., Carlini L., Mattioli G., Vismarra F., Chiarinelli J., Valadan M., Porcelli F., Altucci C., Bolognesi P., Avaldi L., Richter R., Molteni E., Sangalli D., Vismarra, Federico, Singh, Manjot, Mattioli, Giuseppe, Bolognesi, Paola, Sangalli, Davide, Valadan, Mohammadhassan, Chiarinelli, Jacopo, Borrego-Varillas, Rocio, Wu, Yingxuan, Molteni, Elena, Richter, Robert, Casavola, Anna Rita, Avaldi, Lorenzo, Nisoli, Mauro, Altucci, Carlo, Carlini, Laura, Porcelli, Francesco   +33 more
core   +3 more sources

Anticancer activity of the liposome-encapsulated cyclic dipeptides, cyclo(His-Gly) and cyclo(His-Ala)

, 2013
Cyclic dipeptides have been well characterized for their biological activity, including antimicrobial and anticancer activities. Cyclo(His-Gly) and cyclo(His-Ala) have also recently demonstrated significant anticancer activity against a range of cell ...
Milne, P.J., Kilian, G., Davids, H.
core   +1 more source

An Investigations‐Based Undergraduate Computational Chemistry Course

Journal of Physical Organic Chemistry, Volume 39, Issue 11, November 2026.
Chemistry 164 is a hands‐on undergraduate computational chemistry course at Pomona College using publicly available materials (https://tinyurl.com/PomonaChem164) and structured around literature‐based investigations of organic structure and reactivity, isotope effects, NMR parameters, and organometallic systems.
Daniel J. O'Leary
wiley   +1 more source