Results 121 to 130 of about 464,022 (216)

Regulation by the Transcriptional Regulator YdcI in E. coli and (p)ppGpp‐Dependent Activation of ydcI Expression

open access: yesMolecular Microbiology, Volume 126, Issue 5, Page 503-518, November 2026.
YdcI, a LysR‐type transcription regulator in Escherichia coli, regulates loci like iraP and mqo. Its expression is induced by (p)ppGpp under stress conditions, and protein levels rise during mid‐exponential growth, connecting its role to stress response and metabolism control. ABSTRACT YdcI, a LysR‐type transcription regulator, has been associated with
Ria Basu Roy, Karin Schnetz
wiley   +1 more source

Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications

open access: yesAngewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika   +9 more
wiley   +2 more sources

Two new cyclic dipeptides from Rhinocladiella sp. lgt-3, a fungal endophyte isolated from Tripterygiun wilfordii Hook

open access: yes, 2014
Two new cyclic dipeptides, rhinocladin A (1) and rhinocladin B (2), were isolated from a fungal endophyte (Rhinocladiella sp. lgt-3) of Tripterygiun wilfordii Hook. Their structures were elucidated by 1D and 2D NMR spectra.
Dong-Bo Zhang (613611)   +5 more
core   +1 more source

High‐variance phenome database reveals important roles of WD40 proteins in the plant pathogenic fungus Fusarium graminearum

open access: yesNew Phytologist, Volume 252, Issue 3, Page 1215-1231, November 2026.
Functional analysis of predicted interaction‐associated WD40 blades in Fgwd101 and Fgwd048 of Fusarium graminearum. Summary WD40 is a highly conserved protein domain in eukaryotes that functions as a versatile platform for protein–protein interactions and participates in diverse biological processes.
Soyoung Choi   +15 more
wiley   +1 more source

Small Molecule Peptide and the Potential Mechanism of Shanxi Vinegar Based on UPLC-Q-TOF-MS Technology and Network Pharmacology

open access: yesShipin gongye ke-ji
Objective: To elucidate the small molecule peptides in Shanxi vinegar and further explore their potential mechanism of action against cardiovascular and other related diseases.
Liyuan NIE   +4 more
doaj   +1 more source

Prepartum Heat Stress Dysregulates Immune Resilience in Postpartum Dairy Cows

open access: yesThe FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Increasing environmental temperatures pose a major challenge to animal welfare by inducing heat stress and increasing the incidence of disease. Immune resilience is essential for maintaining animal health; however, the mechanisms linking heat stress to immune dysfunction and disease remain unclear.
Arslan Tariq   +10 more
wiley   +1 more source

Downsizing the Histone H3–H4 Quaternary Structure Into Foldamer Mimetics Yields High‐Affinity and Cell‐Permeable Ligands of ASF1

open access: yesAngewandte Chemie, Volume 138, Issue 41, 5 October 2026.
We present a foldamer strategy to downsize the histone H3‐H4 quaternary structure into high‐affinity, medium‐sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide‐oligourea chimeras, designed through structure‐guided optimization and foldamer chemistry, recapitulate the natural H3‐H4 dimer binding mode while demonstrating plasma stability ...
Bo Li   +15 more
wiley   +2 more sources

Quantification of cyclic dipeptides from cultures of Lactobacillus brevis R2Δ by HRGC/MS using stable isotope dilution assay

open access: yes, 2014
Lactic acid bacteria (LAB) play an important role as natural preservatives in fermented food and beverage systems, reducing the application of chemical additives.
Waters MD   +4 more
core  

Photochemical Reaction Discovery Enabled by the Dynamic Speciation of Copper Complexes

open access: yesAngewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A strategy for accelerated photochemical reaction discovery is reported that harnesses the dynamic speciation of copper complexes, driven by their labile metal–ligand bonds. This platform simplifies reaction screening by combining an earth‐abundant copper(II) salt with commercially available ligands, which reversibly generate multiple catalytic species
Alessio Regni   +6 more
wiley   +2 more sources

TRYPTOPHAN-BASED LINEAR DIPEPTIDES AND 1,4-DIKETOPIPERAZINES AS SIMPLIFIED SCAFFOLDS OF THE NATURAL CYCLOTETRAPEPTIDE FR235222 [PDF]

open access: yes, 2014
Design, synthesis and biological evaluation of simplified linear and cyclic peptidomimetic analogues of FR235222 (1), natural immunosuppressant and HDAC inhibitor, bearing hydroxyketone moiety as more stable zinc binding group, have been reported. Linear
RANDINO, ROSARIO   +14 more
core   +1 more source

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