Results 111 to 120 of about 464,022 (216)

Survival of dipeptides under ionizing radiation in astrophysical environments †

open access: yes
Films of linear and cyclic dipeptides as well as alanine amino acid, deposited on ZnSe windows, have been irradiated with a 12 C 4+ beam of 0.98 MeV/u at 10,...
Giuseppe Mattioli   +27 more
core   +1 more source

Automation of the Azapeptide Submonomer Synthesis Method

open access: yesJournal of Peptide Science, Volume 32, Issue 11, November 2026.
The solid phase submonomer azapeptide synthesis method was automated using a commercially available peptide synthesizer. Key findings for the successful automation included the use of stable isocyanate precursor for the semicarbazone installation step, elimination of all cooling steps, use of a heating block, and use of DMF as solvent.
Tyler G. Hobart   +3 more
wiley   +1 more source

Novel 2,5-Diketopiperazines with In Vitro Activities against Protozoan Parasites of Tropical Diseases

open access: yesPharmaceuticals
Malaria, Chagas disease, and leishmaniasis are tropical diseases caused by protozoan parasites of the genera Plasmodium, Trypanosoma and Leishmania, respectively.
Isabela P. Ceravolo   +9 more
doaj   +1 more source

Correlation of electronic structures of three cyclic dipeptides with their photoemission spectra

open access: yes, 2010
We have investigated the electronic structure of three cyclic dipeptides: cyclo (Glycyl-Glycyl) (cGG), cyclo(Leucyl-Prolyl) (cLP), and cyclo(Phenylalanyl-Prolyl) (cPP).
Vitaliy Feyer (1805521)   +4 more
core   +1 more source

A Cilia–Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging

open access: yesAging Cell, Volume 25, Issue 11, November 2026.
Aging‐associated NAD+ depletion in hypothalamic neurons shortens primary cilia and disrupts CHMP4B trafficking to lysosomes during lysosomal stress, leading to impaired TRPML1–mediated Ca2+ signaling and lysosomal stress responses. Calorie restriction restores hypothalamic NAD+ levels, ciliary structure, and lysosomal homeostasis, thereby improving ...
Se Eun Park   +15 more
wiley   +1 more source

Electrocatalytic Polarity Inversion of Azlactones: Access to α‐Quaternary Amino Acids with Electron‐Rich SOMOphiles

open access: yesAngewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Electrocatalytic polarity inversion of azlactones unlocks their coupling with electron‐rich reaction partners. Triarylamine‐mediated oxidation of the azlactone enolate generates an electrophilic radical intermediate that undergoes selective C4 functionalization with diverse SOMOphiles.
Paula Rodríguez   +6 more
wiley   +2 more sources

A Deep Mining Strategy for Peptide Rapid Identification in Lactobacillus reuteri Based on LC–MS/MS Integrated with FBMN and De Novo Sequencing

open access: yesMetabolites
Lactobacillus reuteri (L. reuteri) is widely recognized as a probiotic that produces prebiotics. However, studies on bioactive peptides or amino acid (AA) derivatives produced by L.
Yilang Zuo   +5 more
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown   +2 more
wiley   +1 more source

Lactobacillus plantarum LBP-K10의 Cyclic dipeptides 와 cyclic dipeptide synthetase [PDF]

open access: yes, 2017
학위논문 (박사)-- 서울대학교 대학원 : 생명과학부, 2017. 2. 강사욱.Lactic acid bacteria (LAB) have been recognized to be a probiotic microorganism for human health. Cyclic dipeptides (CDPs) produced by LAB are important for their antibiotic activities.
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