Results 21 to 30 of about 762,133 (379)
Crystal structure and functional implication of bacterial STING
Nature Communications, 2022 The bacterial Cyclic-oligonucleotide-Based Anti-phage Signaling System (CBASS) contains a CD-NTase that synthesizes cyclic di- and tri-nucleotides, and bacterial STING proteins recognize c-di-GMP generated by CD-NTase during phage infection and signal ...
Tzu-Ping Ko +6 more
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Microbiology Spectrum, 2023 Dickeya dadantii is a Gram-negative bacterium that causes soft rot diseases in a variety of plants. This pathogen secretes pectate lyase (Pel) enzymes to degrade the plant cell wall, a process controlled by the bacterial second messenger cyclic ...
Biswarup Banerjee +2 more
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Nucleotides as Bacterial Second Messengers
Molecules, 2023 In addition to comprising monomers of nucleic acids, nucleotides have signaling functions and act as second messengers in both prokaryotic and eukaryotic cells. The most common example is cyclic AMP (cAMP).
Mario E. Cancino-Diaz +3 more
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High levels of cyclic-di-GMP in plant-associated Pseudomonas correlate with evasion of plant immunity [PDF]
, 2016 The plant innate immune system employs plasma membrane-localized receptors that specifically perceive pathogen/microbe-associated molecular patterns (PAMPs/MAMPs).
Aragon +68 more
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Bacterial rotary export ATPases are allosterically regulated by the nucleotide second messenger cyclic-di-GMP [PDF]
, 2015 The widespread second messenger molecule cyclic di-GMP (cdG) regulates the transition from motile and virulent lifestyles to sessile, biofilm-forming ones in a wide range of bacteria. Many pathogenic and commensal bacterial-host interactions are known to
Abel +89 more
core +1 more source
Bacterial cyclic diguanylate signaling networks sense temperature
Nature Communications, 2021 Many bacteria use the second messenger cyclic diguanylate (c-di-GMP) to control motility, biofilm production and virulence. Here, the authors identify a thermosensitive enzyme that synthesizes c-di-GMP and modulates temperature-dependent motility ...
Henrik Almblad +29 more
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Multilimbed membrane guanylate cyclase signaling system, evolutionary ladder
Frontiers in Molecular Neuroscience, 2023 One monumental discovery in the field of cell biology is the establishment of the membrane guanylate cyclase signal transduction system. Decoding its fundamental, molecular, biochemical, and genetic features revolutionized the processes of developing ...
Teresa Duda, Rameshwar K. Sharma
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Direct activation of a phospholipase by cyclic GMP-AMP in El Tor Vibrio cholerae
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Second messengers are employed by all organisms to regulate fundamental behaviors, including biofilm formation, motility, metabolism, and pathogenesis in bacteria.
Geoffrey B. Severin +12 more
semanticscholar +1 more source
Distinct Allostery Induced in the Cyclic GMP-binding, Cyclic GMP-specific Phosphodiesterase (PDE5) by Cyclic GMP, Sildenafil, and Metal Ions [PDF]
Journal of Biological Chemistry, 2011 The activity of many proteins orchestrating different biological processes is regulated by allostery, where ligand binding at one site alters the function of another site. Allosteric changes can be brought about by either a change in the dynamics of a protein, or alteration in its mean structure. We have investigated the mechanisms of allostery induced
Biswas, Kabir Hassan +1 more
openaire +6 more sources
The HD-GYP Domain, Cyclic Di-GMP Signaling, and Bacterial Virulence to Plants
Molecular Plant-Microbe Interactions, 2006 Cyclic di-GMP is an almost ubiquitous second messenger in bacteria that was first described as an allosteric activator of cellulose synthase but is now known to regulate a range of functions, including virulence in human and animal pathogens. Two protein
J. Maxwell Dow +3 more
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