Results 21 to 30 of about 21,563 (124)
Bacterial cyclic diguanylate signaling networks sense temperature
Nature Communications, 2021 Many bacteria use the second messenger cyclic diguanylate (c-di-GMP) to control motility, biofilm production and virulence. Here, the authors identify a thermosensitive enzyme that synthesizes c-di-GMP and modulates temperature-dependent motility ...
Henrik Almblad +29 more
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High Levels of Cyclic Diguanylate Interfere with Beneficial Bacterial Colonization
mBio, 2022 During colonization of the Hawaiian bobtail squid (Euprymna scolopes), Vibrio fischeri bacteria undergo a lifestyle transition from a planktonic motile state in the environment to a biofilm state in host mucus.
Ruth Y. Isenberg +3 more
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Nucleotide binding by the widespread high-affinity cyclic di-GMP receptor MshEN domain
Nature Communications, 2016 Cyclic-di-GMP is a bacterial second messenger that binds to the regulatory domain of ATPases of some bacteria. Here, the authors report the crystal structure of this interaction, identify a cyclic-di-GMP binding mode, and show that this interaction might
Yu-Chuan Wang +8 more
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Guanylin peptides: cyclic GMP signaling mechanisms
Brazilian Journal of Medical and Biological Research, 1999 Guanylate cyclases (GC) serve in two different signaling pathways involving cytosolic and membrane enzymes. Membrane GCs are receptors for guanylin and atriopeptin peptides, two families of cGMP-regulating peptides.
L.R. Forte +3 more
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mSystems, 2022 Modulation of the intracellular cyclic di-GMP (c-di-GMP) pool is central to the formation of structured bacterial communities. Genome annotations predict the presence of dozens of conserved c-di-GMP catalytic enzymes in many bacterial species, but the ...
Collin Kessler, Wook Kim
doaj +1 more source
GMP*: Well-Tuned Gradual Magnitude Pruning Can Outperform Most BERT-Pruning Methods [PDF]
arXiv, 2022 We revisit the performance of the classic gradual magnitude pruning (GMP) baseline for large language models, focusing on the classic BERT benchmark on various popular tasks. Despite existing evidence in the literature that GMP performs poorly, we show that a simple and general variant, which we call GMP*, can match and sometimes outperform more ...
arxiv
eLife, 2017 Activating mutations in fibroblast growth factor (FGF) receptor 3 and inactivating mutations in the NPR2 guanylyl cyclase both cause severe short stature, but how these two signaling systems interact to regulate bone growth is poorly understood. Here, we
Leia C Shuhaibar +13 more
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Occurrence of Cyclic di-GMP-Modulating Output Domains in Cyanobacteria: an Illuminating Perspective
mBio, 2013 Microorganisms use a variety of metabolites to respond to external stimuli, including second messengers that amplify primary signals and elicit biochemical changes in a cell. Levels of the second messenger cyclic dimeric GMP (c-di-GMP) are regulated by a
Marco Agostoni +4 more
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GMP-Featurizer: A parallelized Python package for efficiently computing the Gaussian Multipole features of atomic systems [PDF]
arXiv, 2023 GMP-Featurizer is a lightweight, accurate, efficient, and scalable software package for calculating the Gaussian Multipole (GMP) features \cite{GMP} for a variety of atomic systems with elements across the periodic table. Starting from the GMP feature computation module from AmpTorch \cite{amptorch}, the capability of GMP-Featurizer has since been ...
arxiv
Visualization of c-di-GMP in multicellular Dictyostelium stages
Frontiers in Cell and Developmental Biology, 2023 The bacterial signaling molecule cyclic diguanosine monophosphate (c-di-GMP) is only synthesized and utilized by the cellular slime mold Dictyostelium discoideum among eukaryotes.
Hayato Ide +3 more
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