Results 211 to 220 of about 62,432 (257)

Atrial Natriuretic Peptides and Cyclic Guanosine Monophosphate Metabolism

The American Journal of the Medical Sciences, 1995
Atrial natriuretic factor (ANF), consisting of amino acids 99-126 of the 126 amino acid ANF prohormone, increases cyclic guanosine monophosphate (GMP) (thought to be the mediator of its physiologic effects) in plasma and urine of human subjects. Long-acting natriuretic peptide, vessel dilator, and kaliuretic peptide, consisting of amino acid 1-30, 31 ...
D L, Vesely, A T, Giordano, M A, Douglass, M T, McCormick, G, Rodriguez-Paz, D D, Schocken   +5 more
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Molecular Conformation of Guanosine 3,′5′-Cyclic Monophosphate

Nature New Biology, 1973
THE molecular structure of 5′-methylene adenosine 3′,5′-cyclic monophosphonate (cyclic AMP analogue), a synthetic cyclic nucleotide, has been reported1,2. Here we report the molecular structure of the naturally occurring cyclic nucleotide guanosine 3′,5′-cyclic monophosphate (cyclic GMP).
A K, Chwang, M, Sundaralingam
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Cyclic Guanosine Monophosphate Role in Human Carcinoma Pathogenesis

Nucleosides, Nucleotides and Nucleic Acids, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Di Nicola Maurizio, Santoleri Fiorenzo, Soscia Stefano, Fioroni Massimiliano, Rubini Corrado, PIATTELLI, Adriano, SPOTO, Giuseppe   +6 more
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Dibenzoquinazoline diones as antihypertensive cyclic guanosine monophosphate phosphodiesterase inhibitors

Biochemical Pharmacology, 1987
The discovery and structure-activity of a new class of renal artery phosphodiesterase inhibitors is reported, some of which are highly selective for the guanosine cyclic 3',5'-monophosphate phosphodiesterase. One of these compounds, 5,6-dihydro-8,9,11,12-tetramethoxy-1,3-dioxo-1H-benz[f]- isoquino [8,1,2- hij]quinazoline-2(3H)-carboxylic acid, ethyl ...
R F, Booth, S P, Buckham, D O, Lunt, P W, Manley, R A, Porter   +4 more
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Cyclic Guanosine Monophosphate in Primary Cultures of Glial Cells

Journal of Neurochemistry, 1980
Abstract: Cyclic GMP was found in primary cultures of glial cells obtained by dissociation of newborn mouse brain hemispheres. Its basal level (0.52 pmoles/mg cell protein) was as high as that found in adult mouse brain cortex but 10 times lower than in cerebellum.
M, Bloch-Tardy, C, Fages, P, Gonnard
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Cellular signaling with nitric oxide and cyclic guanosine monophosphate

Seminars in Perinatology, 2000
The understanding of the formation and biological actions of nitric oxide (NO) has grown extensively during the past two decades. With the discoveries of the biological effects of NO and nitrovasodilators on cyclic guanosine monophosphate, with the elucidation of the biochemical mechanisms of NO synthesis, and with the growing knowledge of regulation ...
E, Martin, K, Davis, K, Bian, Y C, Lee, F, Murad   +4 more
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Cyclic Guanosine Monophosphate Mediates Penile Erection in the Rat

European Urology, 1993
Recent in vivo and in vitro studies suggest that nitric oxide or a nitric-oxide-like substance mediates nonadrenergic, noncholinergic relaxation of trabecular smooth muscle through activation of the cyclic guanosine monophosphate (cGMP) pathway. In 60 Sprague-Dawley rats, we investigated the effect of intracavernous administration of different drugs ...
L, Martinez-Piñeiro, F, Trigo-Rocha, G L, Hsu, B, von Heyden, T F, Lue, E A, Tanagho   +5 more
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Cyclic guanosine monophosphate signalling pathway in pulmonary arterial hypertension

Vascular Pharmacology, 2013
During the last decade, it emerged that cyclic guanosine monophosphate (cGMP) is a novel drug target for the treatment of pulmonary arterial hypertension (PAH). cGMP regulates many cellular functions, ranging from contractility to growth, of relevance to the disease.
Chien-nien, Chen, Geoffrey, Watson, Lan, Zhao   +2 more
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Adenosine relaxes vagina smooth muscle through the cyclic guanosine monophosphate– and cyclic guanosine monophosphate–dependent pathways

The Journal of Sexual Medicine
Abstract Background In males, adenosine (ADO) is known to relax penile smooth muscles, although its role in the vagina is not yet fully elucidated. Aim This study investigated the effect of ADO on vagina smooth muscle activity, using ...
Cellai, Ilaria, Filippi, Sandra, Comeglio, Paolo, Guarnieri, Giulia, Acciai, Gabriele, Cancedda, Chiara, Cipriani, Sarah, Maseroli, Elisa, Rastrelli, Giulia, Morelli, Annamaria, Maggi, Mario, Vignozzi, Linda   +11 more
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Cyclic guanosine-3??5?-monophosphate induced diuresis in rats

Naunyn-Schmiedeberg's Archives of Pharmacology, 1974
In excretion studies in dogs it was found that cyclic guanosine-3′∶5′-monophosphate (cGMP) was eliminated by glomerular filtration only. If there is any permeability of the tubule cells to exogenous cGMP, it must be very low. cGMP (5×10−5 moles) injected into the thoracic aorta of rats induced an increase of the renal electrolyte excretion.
H. Osswald, O. Jacobs
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