Results 61 to 70 of about 433,779 (173)

Genome mining for drug discovery: cyclic lipopeptides related to daptomycin [PDF]

Journal of Industrial Microbiology and Biotechnology, 2021
Abstract The cyclic lipopeptide antibiotics structurally related to daptomycin were first reported in the 1950s. Several have common lipopeptide initiation, elongation, and termination mechanisms. Initiation requires the use of a fatty acyl-AMP ligase (FAAL), a free-standing acyl carrier protein (ACP), and a specialized condensation ...
openaire   +2 more sources

State of the Art of Cyclic Lipopeptide–Membrane Interactions: Pore Formation and Bilayer Permeability

Pharmaceutics
Background/Objectives: Resistance of pathogenic microorganisms to antibiotics poses a serious threat to public health and often leads to devastating consequences. In this context, one of the pressing challenges in pharmacochemistry is the search for new,
Anastasiia A. Zakharova, Svetlana S. Efimova, Olga S. Ostroumova   +2 more
doaj   +1 more source

Charting the Lipopeptidome of Nonpathogenic Pseudomonas

mSystems, 2023
A major source of pseudomonad-specialized metabolites is the nonribosomal peptide synthetases (NRPSs) assembling siderophores and lipopeptides. Cyclic lipopeptides (CLPs) of the Mycin and Peptin families are frequently associated with, but not restricted
Catherine Cesa-Luna, Niels Geudens, Léa Girard, Vic De Roo, Hassan R. Maklad, José C. Martins, Monica Höfte, René De Mot   +7 more
doaj   +1 more source

Structural variability of cyclic cyanobacterial lipopeptides: their biosynthesis and features affecting their bioactivity

, 2021
This thesis is devoted to the diversity of cyanobacterial cyclic lipopeptides and their bioactivity. Special class of cyclic cyanobacterial lipopeptides puwainaphycins and minutissamides was studied in terms of their structural diversity, biosynthesis ...
HÁJEK, Jan
core  

A cyclic lipopeptide from Fusarium graminearum targets plant membranes to promote virulence

Cell Reports
Summary: Microbial plant pathogens deploy amphipathic cyclic lipopeptides to reduce surface tension in their environment. While plants can detect these molecules to activate cellular stress responses, the role of these lipopeptides or associated host ...
Elizabeth K. Brauer, Whynn Bosnich, Kirsten Holy, Indira Thapa, Srinivasan Krishnan, Moatter Syed, Melissa Bredow, Amanda Sproule, Monique Power, Anne Johnston, Michel Cloutier, Naveen Haribabu, Izhar U.H. Khan, Jean-Simon Diallo, Jacqueline Monaghan, Denise Chabot, David P. Overy, Rajagopal Subramaniam, Miguel Piñeros, Barbara Blackwell, Linda J. Harris   +20 more
doaj   +1 more source

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control

Biotechnology and Bioengineering, EarlyView.
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Michael Dare Asemoloye
wiley   +1 more source

Bacillus licheniformis: A Producer of Antimicrobial Substances, including Antimycobacterials, Which Are Feasible for Medical Applications

Pharmaceutics, 2023
Bacillus licheniformis produces several classes of antimicrobial substances, including bacteriocins, which are peptides or proteins with different structural composition and molecular mass: ribosomally synthesized by bacteria (1.4–20 kDa), non ...
Margarita O. Shleeva, Daria A. Kondratieva, Arseny S. Kaprelyants   +2 more
doaj   +1 more source

In vitro selection of bacteria resistant to LY146032, a new cyclic lipopeptide [PDF]

Antimicrobial Agents and Chemotherapy, 1988
Isolates of Streptococcus pneumoniae, Enterococcus faecalis, Enterococcus faecium, and coagulase-positive and -negative staphylococci were investigated for their abilities, in vitro, to develop resistance to LY146032. Exposure of the organisms to incremental concentrations of LY146032 resulted in MICs 8- to 32-fold higher than those for the original ...
L D, Liebowitz, J, Saunders, L J, Chalkley, H J, Koornhof   +3 more
openaire   +2 more sources

Induction and Enhancement of Bacteriocin Production (Review)

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Conventionally, bacteriocins are produced by microorganisms on complex substrates, released as semi‐purified preparations or crude fermentates. These bacteriocin‐containing products often exhibit unsatisfactory purity, low active‐substance content, and high production costs, limiting their commercialization and use. This review aims to analyze
Oksana Knysh, Artur Martynov
wiley   +1 more source

Mechanism of Isonitrilase, a Nonheme Iron Decarboxylase Involved in the Biosynthesis of the Isonitrile Group in Peptides: A Computational Study

Chemistry – A European Journal, EarlyView.
A combination of molecular dynamics and quantum mechanics calculations shows that substrate is tightly bound inside the enzyme structure that enables two successive catalytic cycles with dioxygen and α‐ketoglutarate with an initial desaturation followed by hydrogen abstraction and decarboxylation steps to form an isonitrile substituent.
Chengxu Zhu, Sam P. de Visser
wiley   +1 more source