Results 61 to 70 of about 4,338 (170)

A cyclic lipopeptide from Fusarium graminearum targets plant membranes to promote virulence

Cell Reports
Summary: Microbial plant pathogens deploy amphipathic cyclic lipopeptides to reduce surface tension in their environment. While plants can detect these molecules to activate cellular stress responses, the role of these lipopeptides or associated host ...
Elizabeth K. Brauer, Whynn Bosnich, Kirsten Holy, Indira Thapa, Srinivasan Krishnan, Moatter Syed, Melissa Bredow, Amanda Sproule, Monique Power, Anne Johnston, Michel Cloutier, Naveen Haribabu, Izhar U.H. Khan, Jean-Simon Diallo, Jacqueline Monaghan, Denise Chabot, David P. Overy, Rajagopal Subramaniam, Miguel Piñeros, Barbara Blackwell, Linda J. Harris   +20 more
doaj   +1 more source

Bacillus licheniformis: A Producer of Antimicrobial Substances, including Antimycobacterials, Which Are Feasible for Medical Applications

Pharmaceutics, 2023
Bacillus licheniformis produces several classes of antimicrobial substances, including bacteriocins, which are peptides or proteins with different structural composition and molecular mass: ribosomally synthesized by bacteria (1.4–20 kDa), non ...
Margarita O. Shleeva, Daria A. Kondratieva, Arseny S. Kaprelyants   +2 more
doaj   +1 more source

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control

Biotechnology and Bioengineering, EarlyView.
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Michael Dare Asemoloye
wiley   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Cyclic Lipopeptides with Herbicidal and Insecticidal Activities Produced by DTM1

Natural Product Communications, 2015
Seven cyclic lipopeptide biosurfactants (1–7) were isolated for the first time from the fermentation broth of endophytic Bacillus clausii DTM1 and were identified as anteisoC 13 [Val7] surfactin-(L-Glu)-O-methyl-ester (1) , anteisoC 12 [Val7] surfactin ...
Da-Le Guo, Bo Wan, Shi-Ji Xiao, Sarah Allen, Yu-Cheng Gu, Li-Sheng Ding, Yan Zhou   +6 more
doaj   +1 more source

In vitro selection of bacteria resistant to LY146032, a new cyclic lipopeptide [PDF]

Antimicrobial Agents and Chemotherapy, 1988
Isolates of Streptococcus pneumoniae, Enterococcus faecalis, Enterococcus faecium, and coagulase-positive and -negative staphylococci were investigated for their abilities, in vitro, to develop resistance to LY146032. Exposure of the organisms to incremental concentrations of LY146032 resulted in MICs 8- to 32-fold higher than those for the original ...
L D, Liebowitz, J, Saunders, L J, Chalkley, H J, Koornhof   +3 more
openaire   +2 more sources

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Micellar and Solubilization Properties of Biological Surfactant Surfactin

Journal of Surfactants and Detergents, EarlyView.
ABSTRACT We studied aqueous solutions of surfactin in the concentration range of 0.001–200 g/L using NMR diffusometry, tensometry and optical microscopy methods. According to tensometry data, the system forms monolayers of surfactant molecules at the water‐air phase boundary at C = 0.02 g/L.
Victor P. Arkhipov, Ruslan Arkhipov, Natalia Kuzina, Andrei Filippov   +3 more
wiley   +1 more source

Combined application of Bacillus velezensis JDB15 and Trichoderma harzianum JDL4 suppresses banana Fusarium wilt under controlled conditions

Pest Management Science, EarlyView.
The surfactin C secreted by JDB15 and the probable parasitism of JDL4 lead to the leakage of intracellular macromolecules and the degradation of hyphae, respectively. Combined application of the two strains effectively controls banana Fusarium wilt under controlled conditions.
Deng Chen, Minghao Ju, Hongyang Li, Junting Feng, Xueyong Zi, Xuqian Gong, Yida Che, Xiaoya Lei, Zihuan Geng, Hongsen Deng, Kang Zhao, Jianghui Xie, Xiao‐Lin Chen, Jun Peng   +13 more
wiley   +1 more source