Results 41 to 50 of about 375,823 (310)

Mechanical properties and energy evolution characteristics of borehole-containing specimens under disturbances of cyclic incremental stress with different lower limits

open access: yesJournal of Materials Research and Technology, 2023
Drilling gas drainage boreholes in coal mines is a major measure to prevent gas disasters in coal mines. However, coal mining disruptions can affect the stability and shape of gas drainage boreholes.
Xiaoyan Sun, Zihan Chen, Quanle Zou
doaj   +1 more source

Mechanical coupling for high cyclic loading [PDF]

open access: yes, 1974
One-piece cylindrical coupling with ""necked-down'' regions at each end form flexures allowing small misalignments between actuator and load. Coupling has zero backlash, low mass, close spacing between actuator and load, high stiffness in direction of ...
Dustin, M. O., Mehmed, O.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Bearing Performance of a Helical Pile for Offshore Photovoltaic under Horizontal Cyclic Loading

open access: yesJournal of Marine Science and Engineering
For an offshore photovoltaic helical pile foundation, significant horizontal cyclic loading is imposed by wind and waves. To study a fixed offshore PV helical pile’s horizontal cyclic bearing performance, a numerical model of the helical pile under ...
Xinfu Cong   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Coupling effects of bidirectional cyclic loading and loading frequency on pore water pressure of saturated soft clay

open access: yesYantu gongcheng xuebao, 2017
A series of undrained cyclic tests with variable confining pressures are conducted on Ningbo saturated soft clay by using the GDS cyclic triaxial system. In this study, the coupling effects of cyclic deviatoric stress and cyclic confining pressure on the
HUANG Jue-hao 1, 2, CHEN Jian 1, 2, KE Wen-hui 3, ZHONG Yu 4, QIU Yue-feng 1, 2
doaj   +1 more source

The effect of the number of response cycles on the behaviour of reinforced concrete elements subject to cyclic loading [PDF]

open access: yes, 2012
The development of damage in reinforced concrete (RC) structures is a cumulative process. Some damage indices used to quantify damage make use of the number of response cycles as an Engineering Demand Parameter (EDP) relating with damage development ...
Borg, R. C., Rossetto, T., Varum, H.
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Experimental study on deformation behaviors of saturated soft clay under intermittent cyclic loading with various drained conditions

open access: yesYantu gongcheng xuebao
In the previous studies, the cyclic triaxial tests under intermittent cyclic loading are used to study the deformation characteristics of soft clay under traffic loads. Both confining pressure and deviator stress vary cyclically in the stress field under
HUANG Juehao 1, 2, XU Linfeng 3, 1, LU Yuan 5, YAN Wenlong 4, 1, CHEN Jian 1, 2, FU Xiaodong 1, 2
doaj   +1 more source

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