Results 61 to 70 of about 124,896 (264)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The Research on the Seismic Performance of Immersion Joints Under Cyclic Loading

Shock and Vibration
Underground traffic structures can ease the traffic pressure on ground traffic and alleviate the effect of urban heat wave. The structural failure of underground structures caused by earthquakes is one of the crucial hazards in the field of urban ...
Xinjun Cheng, Kunpeng Xu, Shiyuan Li, Liping Jing   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The Influence of Cyclic Loading on the Mechanical Properties of Well Cement

Energies
The cyclic loading generated by injection and production operations in underground gas storage facilities can lead to fatigue damage to cement sheaths and compromise the integrity of wellbores.
Zhen Zhang, Zhongtao Yuan, Sutao Ye, Yang Li, Lvchao Yang, Xueyu Pang, Kaihe Lv, Jinsheng Sun   +7 more
doaj   +1 more source

Comparison of the double loop knot stitch and Kessler stitch for Achilles tendon repair: A biomechanical cadaver study.

PLoS ONE, 2020
Tendon elongation after Achilles tendon (AT) repair is associated with the clinical outcome. Reliable suture techniques are essential to reduce gap formations and to allow early mobilization.
Stephan Frosch, Gottfried Buchhorn, Thelonius Hawellek, Tim Alexander Walde, Wolfgang Lehmann, Jan Hubert   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Advances in Research for Mechanical Characteristics of Vertically Loaded Anchors for Offshore Platforms under Cyclic Loads

Journal of Marine Science and Engineering
Vertically loaded anchors (VLAs) are widely used as mooring foundations in marine environments. Their working conditions typically involve deep-sea seabed, frequently subjected to cyclic loads induced by wind, waves, and currents.
Dapeng Li, Baoliang Zhang, Guoqi Xing, Jian Li   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of permeability evolution law of gas-bearing coal under cyclic loading condition

Meitan kexue jishu
In order to explore the permeability evolution law of gas-bearing coal under different cyclic loading and unloading conditions, raw coal samples were taken as the research object, and cyclic loading-unloading experiments of gas-bearing coal were designed
Dengke WANG, Haohang FENG, Jianping WEI, Xu CHEN, Zhigang JIANG, Xiuzhu YUAN, Yun BAI, Tanggen CAO, Wenchao XIONG   +8 more
doaj   +1 more source