Results 61 to 70 of about 1,209,775 (291)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The effect of the number of response cycles on the behaviour of reinforced concrete elements subject to cyclic loading [PDF]

, 2012
The development of damage in reinforced concrete (RC) structures is a cumulative process. Some damage indices used to quantify damage make use of the number of response cycles as an Engineering Demand Parameter (EDP) relating with damage development ...
Varum, H., Rossetto, T., Borg, R. C.
core  

Anisotropic Mechanical Properties and Fracture Mechanism of Transversely Isotropic Rocks under Uniaxial Cyclic Loading

Applied Sciences
Transversely isotropic rocks, which are special anisotropic materials, are widely encountered in civil, mining, petroleum, geothermal, and radioactive waste-disposal engineering. Rock is frequently subject to cyclic loads resulting from natural and human-
Kaihui Li, Guangzhen Du, Jiangteng Li, Dongya Han, Yan Wang   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

EBSD characterization of martensitic transformation and texture evolution in lean duplex stainless steel under uniaxial loading

Journal of Materials Research and Technology
In this work, EBSD technique was applied to investigate the martensitic transformation characteristics and texture evolution laws in a lean duplex stainless steel (present LDX) along several uniaxial loading paths (i.e., tension, compression, cyclic ...
Shuling Guo, Zhenduo Sun, Na Li, Miao Jin, Lei Chen, Shuo Hao   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Micromechanical modeling if the interactions between the microstructure and the dissipative deformation mechanisms in steels under cyclic loading [PDF]

, 2012
La version éditeur de cette publication est disponible à l'adresse suivante : http://www.sciencedirect.com/science/article/pii/S074964191100194XA micromechanical model is proposed to describe the interactions between the microstructure and the ...
WEBER, Bastien, GALTIER, André, FAVIER, Véronique, Marcel Berveiller, BERVEILLER, Marcel, Bastien Weber, André Galtier, MAREAU, Charles, Charles Mareau, Véronique Favier   +9 more
core   +1 more source

Study on the load-bearing behavior of rock-socketed piles under multidirectional horizontal cyclic loading

河南理工大学学报. 自然科学版
ObjectivesThe horizontal load-bearing mechanism of rock-socketed single piles under different loading paths remains unclear. Therefore， this study investigates the load-bearing behavior of rock-socketed piles subjected to multidirectional horizontal ...
Zheng Can, Shang Wenchang, Song Hexing, Liu Junwei, Lai Huaiyuan, Hu Yukun, Qi Guangyu, Zhang Yingyu, Dai Xingke   +8 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source