Results 61 to 70 of about 4,001,407 (359)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Horizontal Cyclic Bearing Characteristics of Bucket Foundation in Sand for Offshore Wind Turbines

Energies
During the service period, the offshore wind turbine foundation mainly bears the wind load from the upper structure and the periodic loads such as wave load and sea currents from the lower structure. Long-term cyclic loads have an important impact on the
Hanbo Zhai, Puyang Zhang, Junqi Ren
doaj   +1 more source

REINFORCED CONCRETE UNDER CYCLIC LOADING

, 2000
In order to contribute to the on going research effort in this field, an experimental working plan with cylinder steel fibre reinforced concrete specimens under compression cyclic loading was carried out. Sets of five specimens were reinforced with conventional transverse reinforcement of 0, 0.57, 1.71 and 4.01 volume percentage of specimen concrete ...
Barros, Joaquim A. O., Sena-Cruz, José, Delgado, Raimundo, Costa, Aníbal   +3 more
openaire   +2 more sources

Cartilage-on-Cartilage Cyclic Loading Induces Mechanical and Structural Damage

Journal of The Mechanical Behavior of Biomedical Materials, 2019
Cartilage breaks down during mechanically-mediated osteoarthritis (OA). While previous research has begun to elucidate mechanical, structural and cellular damage in response to cyclic loading, gaps remain in our understanding of the link between cyclic ...
Kelly Vazquez, Jacob Andreae, C. Henak
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Deformation theory and energy mechanism of cyclic dynamic mechanical damage for granite in the diversion tunnel under cyclic loading-unloading

iScience
Summary: The diversion tunnel is frequently subjected to cyclic dynamic loads during blasting and mechanical excavation. To explore the theory and mechanism of cyclic dynamic mechanical damage for granite in a diversion tunnel under cyclic loading ...
Rongzhou Yang, Ying Xu
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Anisotropic Mechanical Properties and Fracture Mechanism of Transversely Isotropic Rocks under Uniaxial Cyclic Loading

Applied Sciences
Transversely isotropic rocks, which are special anisotropic materials, are widely encountered in civil, mining, petroleum, geothermal, and radioactive waste-disposal engineering. Rock is frequently subject to cyclic loads resulting from natural and human-
Kaihui Li, Guangzhen Du, Jiangteng Li, Dongya Han, Yan Wang   +4 more
doaj   +1 more source

Axial response of resin-encapsulated cable bolts in monotonic and cyclic loading

, 2023
The ease of use and the design flexibility of cable bolts have made them a popular choice for rock support. Cable bolts can be encapsulated with cementitious grout or resin.
Moosavi, Mahdi, Mahdi Moosavi, McDougall, Kevin, Nourizadeh, Hadi, Sina Anzanpour, Moosavi, Mahdi, Naj Aziz, Aziz, Naj, Ali Mirzaghorbanali, Rastegarmanesh, Ashkan, Mirzaghorbanali, Ali, Kevin McDougall, Anzanpour, Sina, Ashkan Rastegarmanesh, Hadi Nourizadeh   +14 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source