Results 51 to 60 of about 375,823 (310)

Evolution of contact resistance and coupling loss in prototype ITER PF NbTi conductors under transverse cyclic load [PDF]

, 2003
Cyclic energizing of a magnet coil with Cable in Conduit Conductors (CICC), as for fusion applications, results in an anomalous change of the interstrand contact resistance (R/sub c/) and coupling loss (n/spl tau/) due to the alternating transverse ...
Abbas, W., Ilyin, Yu., Kate, H.H.J. ten, Nijhuis, A.   +3 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Deformation theory and energy mechanism of cyclic dynamic mechanical damage for granite in the diversion tunnel under cyclic loading-unloading

iScience
Summary: The diversion tunnel is frequently subjected to cyclic dynamic loads during blasting and mechanical excavation. To explore the theory and mechanism of cyclic dynamic mechanical damage for granite in a diversion tunnel under cyclic loading ...
Rongzhou Yang, Ying Xu
doaj   +1 more source

Energy dissipation and equivalent damping of RC columns subjected to biaxial bending: an investigation based in experimental results [PDF]

, 2012
The cyclic behaviour of reinforced concrete columns have been object of many experimental studies in the recent past years. However, the experimental studies on the biaxial response of RC columns are still limited.
Arêde, A., Costa, A. G., Rodrigues, H., Varum, H.   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Horizontal Cyclic Bearing Characteristics of Bucket Foundation in Sand for Offshore Wind Turbines

Energies
During the service period, the offshore wind turbine foundation mainly bears the wind load from the upper structure and the periodic loads such as wave load and sea currents from the lower structure. Long-term cyclic loads have an important impact on the
Hanbo Zhai, Puyang Zhang, Junqi Ren
doaj   +1 more source

Behaviour of steel fibre reinforced concrete under cyclic compressive loading [PDF]

, 2006
An experimental study was carried out to investigate the behaviour of steel fibre reinforced concrete under cyclic compressive loading. Cylindrical specimens containing two volume fractions (one percent and two percent) of steel fibres and plain concrete
Choubey, U. B., Shukla, Mukesh
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source