Results 61 to 70 of about 3,700,789 (338)
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
iScienceSummary: The diversion tunnel is frequently subjected to cyclic dynamic loads during blasting and mechanical excavation. To explore the theory and mechanism of cyclic dynamic mechanical damage for granite in a diversion tunnel under cyclic loading ...
Rongzhou Yang, Ying Xu
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Effects of cyclic loading on soil-geogrid interaction characteristics [PDF]
E3S Web of ConferencesThe benefits of geosynthetic-reinforced soil systems over conventional earth-retaining structures are now well established. These reinforced systems are often subjected not only to static loads, but also to seismic and/or traffic loads, in which case the
Ferreira Fernanda B. +3 more
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The effect of the number of response cycles on the behaviour of reinforced concrete elements subject to cyclic loading [PDF]
, 2012 The development of damage in reinforced concrete (RC) structures is a cumulative process. Some damage indices used to quantify damage make use of the number of response cycles as an Engineering Demand Parameter (EDP) relating with damage development ...
Borg, R. C., Rossetto, T., Varum, H.
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Applied SciencesTransversely isotropic rocks, which are special anisotropic materials, are widely encountered in civil, mining, petroleum, geothermal, and radioactive waste-disposal engineering. Rock is frequently subject to cyclic loads resulting from natural and human-
Kaihui Li +4 more
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Advances in Civil Engineering, 2021 To explore the pile-soil interaction response in saturated sand under long-term horizontal cyclic loading, a series of indoor 1 g model tests were carried out with self-made loading equipment.
Lei Xing +4 more
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Journal of Materials Research and TechnologyIn this work, EBSD technique was applied to investigate the martensitic transformation characteristics and texture evolution laws in a lean duplex stainless steel (present LDX) along several uniaxial loading paths (i.e., tension, compression, cyclic ...
Shuling Guo +5 more
doaj +1 more source