Results 61 to 70 of about 372,306 (310)

Monopiles subjected to uni- and multi-lateral cyclic loading [PDF]

, 2017
Offshore wind turbines are subjected to significant environmental loads from a combination of current, wind and wave action. Under such conditions, the directions of these environmental loads vary over the service life of the structure and therefore the ...
Arthur, Iain, Bradshaw, Aaron, Donohue, Shane, Gavin, Ken, Glynn, Danny, Keltai, Ryan, MacKinnon, Pauline, Nanda, Satyajeet, Rankin, Barry, Sivakumar, Vinayagamoothy   +9 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Horizontal Cyclic Bearing Characteristics of Bucket Foundation in Sand for Offshore Wind Turbines

Energies
During the service period, the offshore wind turbine foundation mainly bears the wind load from the upper structure and the periodic loads such as wave load and sea currents from the lower structure. Long-term cyclic loads have an important impact on the
Hanbo Zhai, Puyang Zhang, Junqi Ren
doaj   +1 more source

Mechanical response and microscopic damage mechanism of pre-flawed sandstone subjected to monotonic and multilevel cyclic loading: A laboratory-scale investigation

International Journal of Mining Science and Technology, 2023
This study aims to investigate the mechanical response and acoustic emission (AE) characteristic of pre-flawed sandstone under both monotonic and multilevel constant-amplitude cyclic loads.
Kesheng Li, Shengqi Yang, Chuanxiao Liu, Yun Chen, Guanglei Zhang, Qing Ma   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Behaviour of steel fibre reinforced concrete under cyclic compressive loading [PDF]

, 2006
An experimental study was carried out to investigate the behaviour of steel fibre reinforced concrete under cyclic compressive loading. Cylindrical specimens containing two volume fractions (one percent and two percent) of steel fibres and plain concrete
Choubey, U. B., Shukla, Mukesh
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Deformation theory and energy mechanism of cyclic dynamic mechanical damage for granite in the diversion tunnel under cyclic loading-unloading

iScience
Summary: The diversion tunnel is frequently subjected to cyclic dynamic loads during blasting and mechanical excavation. To explore the theory and mechanism of cyclic dynamic mechanical damage for granite in a diversion tunnel under cyclic loading ...
Rongzhou Yang, Ying Xu
doaj   +1 more source

Effects of cyclic loading on soil-geogrid interaction characteristics [PDF]

E3S Web of Conferences
The benefits of geosynthetic-reinforced soil systems over conventional earth-retaining structures are now well established. These reinforced systems are often subjected not only to static loads, but also to seismic and/or traffic loads, in which case the
Ferreira Fernanda B., Vieira Castorina S., Lopes Maria de Lurdes, Ferreira Pedro G.   +3 more
doaj   +1 more source