Results 71 to 80 of about 372,306 (310)

Heterogeneous relaxation dynamics in amorphous materials under cyclic loading [PDF]

open access: yes, 2013
Molecular dynamics simulations are performed to investigate heterogeneous dynamics in amorphous glassy materials under oscillatory shear strain. We consider three-dimensional binary Lennard-Jones mixture well below the glass transition temperature.
Priezjev, Nikolai V.
core   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Anisotropic Mechanical Properties and Fracture Mechanism of Transversely Isotropic Rocks under Uniaxial Cyclic Loading

open access: yesApplied Sciences
Transversely isotropic rocks, which are special anisotropic materials, are widely encountered in civil, mining, petroleum, geothermal, and radioactive waste-disposal engineering. Rock is frequently subject to cyclic loads resulting from natural and human-
Kaihui Li   +4 more
doaj   +1 more source

The effect of the number of response cycles on the behaviour of reinforced concrete elements subject to cyclic loading [PDF]

open access: yes, 2012
The development of damage in reinforced concrete (RC) structures is a cumulative process. Some damage indices used to quantify damage make use of the number of response cycles as an Engineering Demand Parameter (EDP) relating with damage development ...
Borg, R. C., Rossetto, T., Varum, H.
core   +1 more source

Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytes [PDF]

open access: yes, 2013
Repetitive strain or ‘overuse’ is thought to be a major factor contributing to the development of tendinopathy. The aims of our study were to develop a novel cyclic loading system, and use it to investigate the effect of defined loading conditions on the
Jones, Gavin   +3 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

EBSD characterization of martensitic transformation and texture evolution in lean duplex stainless steel under uniaxial loading

open access: yesJournal of Materials Research and Technology
In this work, EBSD technique was applied to investigate the martensitic transformation characteristics and texture evolution laws in a lean duplex stainless steel (present LDX) along several uniaxial loading paths (i.e., tension, compression, cyclic ...
Shuling Guo   +5 more
doaj   +1 more source

Experimental Study on Pile-Soil Interaction Response in Saturated Sand under Long-Term Horizontal Cyclic Loading

open access: yesAdvances in Civil Engineering, 2021
To explore the pile-soil interaction response in saturated sand under long-term horizontal cyclic loading, a series of indoor 1 g model tests were carried out with self-made loading equipment.
Lei Xing   +4 more
doaj   +1 more source

Low cycle fatigue life improvement of AISI 304 by initial and intermittent wire brush hammering [PDF]

open access: yes, 2013
The effects of hammering by wire brush as a method of improving low cycle fatigue life of highly ductile austenitic stainless steel AISI 304 have been investigated through an experimental study combining imposed strain fatigue tests and assessment of ...
BRAHAM, Chedly   +4 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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